公开(公告)号：JP2003261546A

公开(公告)日：2003-09-19

申请号：JP2002355604

申请日：2002-12-06

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/66 ,  B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a new process for the continuous preparation of a 5- alkoxy-substituted oxazole in high yield and high space-time yield. SOLUTION: The process for the continuous preparation of a 5-alkoxy- substituted oxazole of formula I (R 1 is a substituted or unsubstituted 1-6C alkyl; and R 2 is H or a substituted or unsubstituted 1-6C alkyl) comprises the conversion of a continuously charged α-isocyanoalkanoic acid ester of formula II to the 5-alkoxy-substituted oxazole of formula I in a reactor at ≥80°C in the presence of an assistant selected from continuously charged alcohols and esters and the continuous discharge of the reaction product from the reactor. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2003026620A

公开(公告)日：2003-01-29

申请号：JP2002130876

申请日：2002-05-02

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： ANSMANN ANDREAS ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  ETZRODT HEINZ ,  OOST CARSTEN ,  STUTZ SUSANNE ,  TRAGUT CHRISTIAN ,  BOCKSTIEGEL BERNHARD ,  REIMER KLAUS ,  STROEZEL MANFRED ,  DOBLER WALTER

IPC: B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/02 ,  C07B61/00 ,  C07C29/17 ,  C07C29/32 ,  C07C29/42 ,  C07C33/02 ,  C07C33/048 ,  C07C45/48 ,  C07C45/62 ,  C07C45/67 ,  C07C49/203

CPC classification number: C07C49/203 ,  B01J23/44 ,  B01J23/50 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0225 ,  C07C29/17 ,  C07C29/42 ,  C07C45/62 ,  C07C45/676 ,  C07C33/02 ,  C07C33/048 ,  C07C49/04

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a higher α,β-unsaturated alcohol in which engineering is easily performed. SOLUTION: This method for producing the alcohol represented by formula Ia or Ib [R is a 1-4C alkyl group; R is a group of formula II (R is hydrogen or a 1-4C alkyl group; a broken line is an additional double bond; and n is 0 or 1-6), hydrogen, or a saturated alkyl group] comprises (a) mono-ethynylating a ketone or formula: R -CO-CH2 -R in ammonia solution by using a basic catalyst, (b) optionally hydrogenating the alcohol of formula Ib on a Pd catalyst, and (c) subjecting the hydrogenated product to a purification distillation, and if necessary, reacting Ia or Ib produced by the steps (a) to (c) or by the steps (a) and (c) with an alkyl acetoacetate of formula IV [R is a 1-4C alkyl group], or a diketene to provide a methyl ketone, and using the ketone as a starting material in the steps (a) to (c).

Abstract translation: 要解决的问题：提供一种制造其中易于进行工程的较高α，β-不饱和醇的方法。 解决方案：用于制备由式Ia或Ib表示的醇的方法[R 1]是1-4C烷基; R 2是式II的基团（R 3是氢或1-4C烷基;虚线是另外的双键; n是0或1-6），氢或饱和烷基 基团]包括（a）通过使用碱性催化剂在氨溶液中使酮或式：R 1 -CO-CH 2 -R 2单乙炔基化，（b）任选地在Pd催化剂上氢化式Ib的醇 和（c）使氢化产物进行纯化蒸馏，如果需要，使由步骤（a）至（c）或步骤（a）和（c）制备的Ia或Ib与式 IV [R 5是1-4C烷基]或二烯酮以提供甲基酮，并且在步骤（a） - （c）中使用酮作为原料。

公开(公告)号：JP2002105087A

公开(公告)日：2002-04-10

申请号：JP2001217030

申请日：2001-07-17

Applicant: BASF AG

Inventor： PREISS THOMAS DR ,  FRIEDRICH HOLGER DR ,  HENKELMANN JOCHEM

IPC: C07B61/00 ,  C07F7/14 ,  C07F7/18 ,  C08F4/06 ,  C08F4/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for preparing a vinylsilane by which a high conversion rate accompanied with a high selectivity can be achieved with an ultrahigh space time yield. SOLUTION: A silane is added to a liquid phase containing an acetylenic hydrocarbon and a catalyst in the method for preparing the vinylsilane comprising reacting the acetylenic hydrocarbon with the silane having at least one silicon-bound hydrogen atom in the presence of a catalyst in the liquid phase. In particular, the reaction is carried out under a superatomic pressure and the spent acetylenic hydrocarbon is replenished during the reaction so as to maintain a pressure which is constant during the entire reaction. As a specific example, acetylene is reacted with trimethoxysilane in the presence of a tetramethyldivinyldisiloxaneplatinum solution in xylene as the catalyst in the xylene liquid phase to produce trimethoxyvinylsilane in high yield.

公开(公告)号：JPH08225479A

公开(公告)日：1996-09-03

申请号：JP28074395

申请日：1995-10-27

Applicant: BASF AG

Inventor： HEIDER MARC ,  RUEHL THOMAS ,  HELFERT HERBERT ,  SCHMIDT-RADDE MARTIN ,  HENKELMANN JOCHEM

IPC: B01J23/02 ,  B01J31/02 ,  B01J31/12 ,  C07B61/00 ,  C07C41/06 ,  C07C41/08 ,  C07C43/178

公开(公告)号：JP2003267958A

公开(公告)日：2003-09-25

申请号：JP2002355822

申请日：2002-12-06

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  BECKER MICHAEL

IPC: B01D3/14 ,  B01J14/00 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole, especially a 4-methyl-5-alkoxy-substituted oxazole and further a method for producing a pyridoxine derivative. SOLUTION: The method for producing the substituted oxazole is carried out as follows. An α-isocyanoalkanoic acid ester is converted into the 5-alkoxy- substituted oxazole in the presence of an assistant composed of an alcohol or an ester at >80°C. The resultant 5-alkoxy-substituted oxazole is taken out of the reactional mixture simultaneously with the conversion. COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2003201283A

公开(公告)日：2003-07-18

申请号：JP2002227742

申请日：2002-08-05

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  MOHRY ANDRE

IPC: C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for continuously producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative by using the same. SOLUTION: This method for obtaining a pyridoxine derivative is provided by converting an α-isocyanoalkanoic acid ester expressed by the formula II in the presence of continuously supplied base at ≥80°C temperature to a 5- alkoxy-substituted oxazole I, taking it out from a reactor at the same time with the reaction, performing a reaction of the compound I with a compound VI to make a compound VII, and acid-treating it to obtain a pyridoxine derivative IX (in formulae, R 1 is an alkyl, R 2 is H or an alkyl, R 3 , R 4 are each independently a protection group of hydroxy group). COPYRIGHT: (C)2003,JPO

公开(公告)号：JP2003176272A

公开(公告)日：2003-06-24

申请号：JP2002227292

申请日：2002-08-05

Applicant: BASF AG

Inventor： RUST HARALD ,  BURKART KIRSTEN ,  FAUST TILLMANN ,  HENKELMANN JOCHEM ,  KINDLER ALOIS ,  KNOLL CHRISTIAN ,  BECKER MICHAEL

IPC: C07D233/70 ,  C07D213/67 ,  C07D263/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a 5-alkoxy-substituted oxazole and a method for producing a pyridoxine derivative. SOLUTION: The 5-alkoxy-substituted oxazole is obtained by converting an α-isocyano alkylic acid ester in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, and the pyridoxine derivative is obtained by converting an amino acid into an amino acid ester, converting the obtained into a formamido acid ester, converting the obtained into an α-isocyanoalkyl acid ester, converting the obtained into a 5-alkoxy-substituted oxazole in the presence of a base at >80°C and separating the 5-alkoxy-substituted oxazole from the reaction mixture simultaneously with the converting reaction, reacting the obtained 5-alkoxy-substituted oxazole with a protective diol to obtain an Diels-Alder adduct and treating the obtained with an acid and removing the protective group to convert into the pyridoxine derivative. COPYRIGHT: (C)2003,JPO

公开(公告)号：JPH09124555A

公开(公告)日：1997-05-13

申请号：JP23444396

申请日：1996-09-04

Applicant: BASF AG

Inventor： WETTLING THOMAS ,  DIMMLER MANFRED ,  HUPFELD BERND ,  HENKELMANN JOCHEM

IPC: C07D307/12 ,  C07C67/08 ,  C07C69/712 ,  C07C69/736

公开(公告)号：WO0230851A3

公开(公告)日：2002-10-31

申请号：PCT/EP0111649

申请日：2001-10-09

Applicant: BASF AG ,  BOETTCHER ARND ,  HENKELMANN JOCHEM ,  HAAKE MATHIAS ,  KAIBEL GERD

Inventor： BOETTCHER ARND ,  HENKELMANN JOCHEM ,  HAAKE MATHIAS ,  KAIBEL GERD

IPC: B01J23/46 ,  B01J23/40 ,  B01J23/56 ,  B01J35/04 ,  B01J37/02 ,  C07B35/02 ,  C07B61/00 ,  C07C5/10 ,  C07C13/18 ,  C07C209/72 ,  C07C211/35

CPC classification number: C07C209/72 ,  B01J23/40 ,  B01J23/462 ,  B01J23/56 ,  B01J35/04 ,  B01J37/0225 ,  C07B35/02 ,  C07C5/10 ,  C07C2521/06 ,  C07C2521/10 ,  C07C2521/18 ,  C07C2523/02 ,  C07C2523/10 ,  C07C2523/30 ,  C07C2523/46 ,  C07C2601/14 ,  C07C211/35

Abstract: The invention relates to a method for the hydrogenation of unsubstituted or at least monoalkyl substituted uni- or poly-nuclear aromatics by means of bringing the above at least one aromatic into contact with a gas containing hydrogen, in the presence of a catalyst comprising at least one metal of sub-group VIII of the periodic system as active metal, supported on a structured or monolithic support.

Abstract translation: 本发明涉及一种用于未取代的氢化或通过所述气体的至少一个芳族与周期系第VIII。分组的在催化剂的存在下，包含作为活性金属含氢至少一种金属接触与至少一个烷基或多核芳族化合物取代一次， 施加到结构化的或整体式载体，其包括

公开(公告)号：WO0119767A3

公开(公告)日：2002-02-14

申请号：PCT/EP0008514

申请日：2000-08-31

Applicant: BASF AG ,  BUSCH RALPH ,  KNEUPER HEINZ JOSEF ,  WEBER THEODOR ,  MUELLER WINFRIED ,  STAMM ARMIN ,  HENKELMANN JOCHEM

Inventor： BUSCH RALPH ,  KNEUPER HEINZ-JOSEF ,  WEBER THEODOR ,  MUELLER WINFRIED ,  STAMM ARMIN ,  HENKELMANN JOCHEM

IPC: C07B61/00 ,  C07C51/00 ,  C07C51/64 ,  C07C53/42 ,  C07C57/66 ,  C07C53/38 ,  C07C57/64

CPC classification number: C07C51/64 ,  C07C53/42

Abstract: The invention relates to a method for purifying acid chlorides which have been produced by converting carboxylic acids with carbon oxychloride or thionyl chloride in the presence of a catalyst adduct. The acid chlorides are treated with a hydro halide of carboxylic acid amides of general formula (I), wherein R stands for hydrogen or C1- to C3-alkyl; R and R , independently from one another, mean C1- to C4-alkyl or R and R together mean a C4- or C5-alkylene chain. The thus purified acid chloride is isolated by separation said acid chloride from the carboxylic acid amide hydro halide-phase.

Abstract translation: 一种用于已制备由羧酸与光气或亚硫酰氯在催化剂的加合物的存在下，其中具有通式（I）的羧酰胺的氢卤化物的羰基氯化物，其中R <1>是氢或反应羰基氯化物的提纯方法 C1-C3烷基; [R <2>和R <3>独立地是C1-C4烷基或R <2>和R <3>一起表示C 4或C 5亚烷基链，从羧酰胺氢卤化物处理，这样纯化的羧酸酰基氯的分离 相隔离。