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公开(公告)号：JP2000143576A
公开(公告)日：2000-05-23
申请号：JP28592699
申请日：1999-10-06
Applicant: BASF AG
Inventor： RUFF DETLEF DR , BAUMANN DIETER , AQUILA WERNER DR , SCHUBERT JUERGEN , LECHTKEN PETER
Abstract: PROBLEM TO BE SOLVED: To provide a method for purifying or isolating 2,3,5-trimethyl-p- benzoquinone by surely removing intermediates and by-products formed during production of the compound and avoiding degradation of the component by diminishing the thermal stress caused by the treatment by separating the compound by the crystallization. SOLUTION: A method is provided for purifying 2,3,5-trimethyl-p-benzoquinone (TMQ) or isolating TMQ from a TMQ-containing mixture by separating by crystallizing preferably at -6 to 32 deg.C. A TMQ-containing mixture to be purified or TMQ contains TMQ preferably at 1-99.999 wt.%, more preferably at 90-99.999 wt.%. The TMQ-containing mixture is formed preferably by the catalytic oxidation of trimethylphenol. TMQ is a useful intermediate for the production of trimethylhydroquinone which is a precursor for the synthesis of α-tocopherol.
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公开(公告)号：JP2000095776A
公开(公告)日：2000-04-04
申请号：JP26767299
申请日：1999-09-21
Applicant: BASF AG
Inventor： BALDENIUS KAI-UWE DR , BOCKSTIEGEL BERNHARD DR , HAGEN IEEDIKKE , RUFF DETLEF DR , SIEDENBIEDEL CARSTEN DR , STUERMER RAINER DR
IPC: C07D311/70 , C07D311/72
Abstract: PROBLEM TO BE SOLVED: To economically and safely obtain the subject compound useful as a biological agent by reaction of a specific oxochromanol derivative with metallic zinc in the presence of an acid or the like to effect reduction of the derivative so as not to change the double bond form or the like in the unsaturated side chain by isomerization or the like. SOLUTION: This compound of formula II (e.g. γ-tocotrienol) is obtained by reaction of a 4-oxo-chromanol derivative of formula I ((n) is 1-10; R1 to R4 are each H or a 1-4C alkyl; R5 is H, a 1-4C alkyl or the like) (e.g. 4-oxo-γ- tocotrienol) with a metallic zinc pref. at 1-0 molar equivalent based on the compound of formula I in the presence of an acid or acid mixture (pref. hydrochloric acid) pref. in an organic solvent such as n-heptane pref. at 20-100 deg.C normally 10 min to 24 h to effect reduction of the derivative of formula I.
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公开(公告)号：JPH11292819A
公开(公告)日：1999-10-26
申请号：JP6492199
申请日：1999-03-11
Applicant: BASF AG
Inventor： RUFF DETLEF DR , BURST WOLFRAM , KAISER WULF DR , STROEZEL MANFRED
IPC: C07C45/72 , C07C45/74 , C07C49/603
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing 2,5,6-trimethyl-2-cyclohexen-1-one in industrial scale, good yield and good space time yield. SOLUTION: This method for producing 2,5,6-trimethyl-2-cyclohexen-1-on comprises simultaneously pumping 1 mol crotonaldehyde or 1 mol compound which is converted under the reaction conditions into crotonaldehyde, about 5-30 mol diethyl ketone and the aqueous solution or suspension of a strong base in the presence of a base agent at elevated temperature, through separate lines or at least partly in the form of a suitable mixture, continuously into a pressure vessel, which is heated where appropriate and which ensures vigorous mixing, in such a way that the reaction temperature is 150-350 deg.C and the average residence time in the pressure vessel is about 0.1 second to 20 min.
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Patent Agency Ranking
公开(公告)号：DK1094056T3
公开(公告)日：2004-03-29
申请号：DK00120644
申请日：2000-09-21
Applicant: BASF AG
Inventor： SCHEIN KARIN DR , BALDENIUS KAI-UWE DR , SIEGEL WOLFGANG DR , STUERMER RAINER DR , RUFF DETLEF DR , JAEDICKE HAGEN DR
IPC: C07B61/00 , C07C45/46 , C07C49/825 , C07C67/42 , C07C69/017 , C07C69/16
Abstract: Preparation of monoacetylated hydroquinone compound comprises reacting a dicetylphenol compound with peroxo compounds optionally using an acid in one reaction step. Preparation of monoacetylated hydroquinone compound of formula (I) comprises reacting a dicetylphenol compound of formula (II) with peroxo compounds optionally using an acid. R1-R3 = H or Me. Independent claims are included for: (1) preparation of (II) by reacting phenol compounds of formula (III) with an acetylation agent using an acid catalyst; (2) preparation of monoacetylated hydroquinone compounds (I) by reacting (III) with an acetylation agent using an acid catalyst to give (II) and further reacting with peroxo compounds, optionally in the presence of an acid; and (3) compounds of formula (Ia)-(Ie).
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公开(公告)号：ES2215533T3
公开(公告)日：2004-10-16
申请号：ES00120644
申请日：2000-09-21
Applicant: BASF AG
Inventor： SCHEIN KARIN DR , BALDENIUS KAI-UWE DR , SIEGEL WOLFGANG DR , STURMER RAINER DR , RUFF DETLEF DR , JAEDICKE HAGEN DR
IPC: C07B61/00 , C07C45/46 , C07C49/825 , C07C67/42 , C07C69/017 , C07C69/16
Abstract: Preparation of monoacetylated hydroquinone compound comprises reacting a dicetylphenol compound with peroxo compounds optionally using an acid in one reaction step. Preparation of monoacetylated hydroquinone compound of formula (I) comprises reacting a dicetylphenol compound of formula (II) with peroxo compounds optionally using an acid. R1-R3 = H or Me. Independent claims are included for: (1) preparation of (II) by reacting phenol compounds of formula (III) with an acetylation agent using an acid catalyst; (2) preparation of monoacetylated hydroquinone compounds (I) by reacting (III) with an acetylation agent using an acid catalyst to give (II) and further reacting with peroxo compounds, optionally in the presence of an acid; and (3) compounds of formula (Ia)-(Ie).
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公开(公告)号：DE19649564A1
公开(公告)日：1998-06-04
申请号：DE19649564
申请日：1996-11-29
Applicant: BASF AG
Inventor： KAESHAMMER STEFAN DR , RUFF DETLEF DR
Abstract: Improved method for the production of gamma , delta -unsaturated ketones desired as odoriferous substances or as intermediate products for vitamins or carotinoids by the reaction of tertiary allyl alcohols and alkenyl alkyl ethers in the presence of acid catalyzers at high temperature. It is characterized in that the reaction is carried out in the presence of a phosphorus derivative of general formula (IV), in which A and B stand for a branched or unbranched alkyl or alkoxy radical with 1 to 10 C atoms, an optionally substituted aryl radical, cycloalkyl radical, aryloxy radical or cycloalkyloxy radical. In addition, A can stand for -H or -OH, or A and B together stand for an optionally substituted tetramethylene or pentamethylene radical, or for an optionally substituted phenyl-1,2-diol radical or a 1,1'-binaphthyl-2,2'-diol radical.
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公开(公告)号：AT260236T
公开(公告)日：2004-03-15
申请号：AT00120644
申请日：2000-09-21
Applicant: BASF AG
Inventor： SCHEIN KARIN DR , BALDENIUS KAI , SIEGEL WOLFGANG DR , STUERMER RAINER DR , RUFF DETLEF DR , JAEDICKE HAGEN DR
IPC: C07B61/00 , C07C45/46 , C07C49/825 , C07C67/42 , C07C69/017 , C07C69/16
Abstract: Preparation of monoacetylated hydroquinone compound comprises reacting a dicetylphenol compound with peroxo compounds optionally using an acid in one reaction step. Preparation of monoacetylated hydroquinone compound of formula (I) comprises reacting a dicetylphenol compound of formula (II) with peroxo compounds optionally using an acid. R1-R3 = H or Me. Independent claims are included for: (1) preparation of (II) by reacting phenol compounds of formula (III) with an acetylation agent using an acid catalyst; (2) preparation of monoacetylated hydroquinone compounds (I) by reacting (III) with an acetylation agent using an acid catalyst to give (II) and further reacting with peroxo compounds, optionally in the presence of an acid; and (3) compounds of formula (Ia)-(Ie).
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公开(公告)号：AT232194T
公开(公告)日：2003-02-15
申请号：AT99119143
申请日：1999-10-05
Applicant: BASF AG
Inventor： RUFF DETLEF DR , BAUMANN DIETER , AQUILA WERNER DR , SCHUBERT JUERGEN DR , LECHTKEN PETER DR
Abstract: Purification of 2,3,5-trimethyl-p-benzoquinone (TMQ) or isolation of TMQ from a mixture, by crystallization. An Independent claim is included for preparation of TMQ by catalytic oxidation of TMP with oxygen to give a mixture containing TMQ as well as TMP and/or at least 1 of solvent, catalyst-residue, by-product and intermediate, followed by work-up as above.
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