-
公开(公告)号:JP2001026565A
公开(公告)日:2001-01-30
申请号:JP2000188222
申请日:2000-06-22
Applicant: BASF AG
Inventor: KLATT MARTIN JOCHEN , MUELLER THOMAS , BOCKSTIEGEL BERNHARD DR
IPC: B01J31/18 , B01J31/22 , C07B61/00 , C07C45/34 , C07C45/86 , C07C49/403 , C07C49/603
Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound by a method providing excellent yield, selectivity and space time yield by oxidizing a specific compound with molecular oxygen in a solvent in the presence of a base, a specific catalyst and a specific additive. SOLUTION: This compound is obtained by oxidizing (A) 3,5,5-trimethyl- cyclohex-3-ene-1-one with (B) molecular oxygen in the presence of (C) a base, (D) a catalyst of the formula R1 to R8 are each H, a halogen, NO2, COR9, SO3R9 (R9 is H or a 1-4C alkyl), or the like; M is Mn (II), Mn (III)(+)X(-) [X(-) is a counterion with a negative charge in the case of a metal used in an oxidation stage III], Co (II), or the like} and (E) an additive comprising an acetate of the formula (R10R11R12C-COO(-))mY(m+) (R10 to R12 are each H, F, a 1-4C alkyl, or the like; Y is NH4+ or a metal cation of the main groups 1-4 with 1-4 valence (s); (m) is 1-4) (e.g. lithium acetate) in (F) a solvent (e.g. dimethylformamide).
-
公开(公告)号:JP2000095776A
公开(公告)日:2000-04-04
申请号:JP26767299
申请日:1999-09-21
Applicant: BASF AG
Inventor: BALDENIUS KAI-UWE DR , BOCKSTIEGEL BERNHARD DR , HAGEN IEEDIKKE , RUFF DETLEF DR , SIEDENBIEDEL CARSTEN DR , STUERMER RAINER DR
IPC: C07D311/70 , C07D311/72
Abstract: PROBLEM TO BE SOLVED: To economically and safely obtain the subject compound useful as a biological agent by reaction of a specific oxochromanol derivative with metallic zinc in the presence of an acid or the like to effect reduction of the derivative so as not to change the double bond form or the like in the unsaturated side chain by isomerization or the like. SOLUTION: This compound of formula II (e.g. γ-tocotrienol) is obtained by reaction of a 4-oxo-chromanol derivative of formula I ((n) is 1-10; R1 to R4 are each H or a 1-4C alkyl; R5 is H, a 1-4C alkyl or the like) (e.g. 4-oxo-γ- tocotrienol) with a metallic zinc pref. at 1-0 molar equivalent based on the compound of formula I in the presence of an acid or acid mixture (pref. hydrochloric acid) pref. in an organic solvent such as n-heptane pref. at 20-100 deg.C normally 10 min to 24 h to effect reduction of the derivative of formula I.
-
公开(公告)号:JP2000086566A
公开(公告)日:2000-03-28
申请号:JP25309699
申请日:1999-09-07
Applicant: BASF AG
Inventor: OOST CARSTEN , STROEZEL MANFRED , ETZRODT HEINZ , DIETMAR WELLER , BOCKSTIEGEL BERNHARD DR , REIMER KLAUS , KAIBEL GERD DR , JAEDICKE HAGEN DR
IPC: B01J31/14 , B01D3/00 , B01D3/14 , B01D3/32 , B01J10/00 , B01J19/24 , C07B61/00 , C07C45/67 , C07C45/68 , C07C45/82 , C07C49/203 , C07C67/54 , C07C69/72
Abstract: PROBLEM TO BE SOLVED: To continuously produce an unsaturated ketone in high yield for a short time in a single reactor without using a medium-boiling material by reacting an unsaturated alcohol with an alkyl acetoacetate in the presence of an organic aluminum compound. SOLUTION: The purpose of this invention is achieved by reacting an unsaturated alcohol of formula I [R1 is a 1-4C alkyl; R2 is a (methoxy-substituted) (1-37C) aliphatic hydrocarbon group or the like] with an alkyl acetoacetate of formula II (R3 is a 1-5C alkyl) on the internal structure of a rectifier to form an acetoacetate of an unsaturated alcohol, by separating an alcohol of the formula R3-OH from the overhead flow of the rectifier, and (A) by making the resultant acetoacetate of an alcohol of formula I rearrange into an unsaturated ketone of formula III in the presence of an organic aluminum compound (pref. an aluminum trialkoxide) in the lower part of the rectifier and/or (B) by feeding carbon dioxide formed each time at the bottom of the rectifier to the overhead flow through the rectifier and by separating an unsaturated ketone of formula III from the rectifier through the bottom.
-
公开(公告)号:JP2001181224A
公开(公告)日:2001-07-03
申请号:JP2000385366
申请日:2000-12-19
Applicant: BASF AG
Inventor: REIMER KLAUS , KAIBEL GERD DR , KAMMEL ULRICH , BROECKER FRANZ JOSEF DR , ANSMANN ANDREAS , ETZRODT HEINZ , STROEZEL MANFRED , HAAKE MATHIAS , LAUPICHLER LOTHAR , BOCKSTIEGEL BERNHARD DR
IPC: B01J23/44 , B01J23/50 , B01J35/04 , B01J35/06 , B01J37/02 , B01J37/08 , C07B61/00 , C07C5/09 , C07C29/17 , C07C33/02 , C07C33/03
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an alkene by partially hydrogenating a 10-30C alkyne. SOLUTION: A palladium compound or, if needed, other metal ion is applied to a heat treated and cooled support material by impregnating a solution containing a palladium salt or, if needed, other metal ion and subsequent drying and 10-2,000 ppm of carbon monoxide (CO) is added or a corresponding amount of CO is generated by a slight decomposition of a compound capable of releasing CO under the reaction condition and added to the reaction mixture.
-
公开(公告)号:JP2001031615A
公开(公告)日:2001-02-06
申请号:JP2000189393
申请日:2000-06-23
Applicant: BASF AG
Inventor: KLATT MARTIN JOCHEN , MUELLER THOMAS , BOCKSTIEGEL BERNHARD DR
IPC: B01J31/22 , B01J31/18 , C07B61/00 , C07C45/34 , C07C49/603
Abstract: PROBLEM TO BE SOLVED: To provide a method of oxidizing β-isophorone using a manganese- salen complex, in high efficiency, also in high yield, selectivity and space time yield each convertible to large industrial scale even in case of high starting material concentration. SOLUTION: This method comprises oxidizing 3,5,5-trimethylcyclohex-3-en-1- one with molecular oxygen in the presence of a base, a solvent and a catalyst to produce the objective 3,5,5-trimethylcyclohex-2-ene-1,4-dione; wherein a manganese-salen complex of the formula [R is hydrogen or Cl; M is Mn(II) or Mn(III)(+)Cl(-)] is used as the catalyst.
-
公开(公告)号:JPH11199537A
公开(公告)日:1999-07-27
申请号:JP29670098
申请日:1998-10-19
Applicant: BASF AG
Inventor: ETZRODT HEINZ , DIETMAR WELLER , OOST CARSTEN , JAEDICKE HAGEN , STROEZEL MANFRED , BOCKSTIEGEL BERNHARD DR
Abstract: PROBLEM TO BE SOLVED: To easily obtain the subject compound useful as a precursor of vitamin E or the like with almost no production of byproducts by reacting a specific allyl alcohol with a specific diketene or the like in the presence of a specific aluminum catalyst by Carroll reaction. SOLUTION: This compound of formula III is obtained by reacting (A) an allyl alcohol of formula I (R is H or the like) with (B) a diketene or an acetoacetic acid alkyl ester of formula II (R is a 1-5C alkyl) by using (C) an aluminum compound which has one or more groups of acetoacetic acid alkyl ester and one or two of alkoxyl groups, or an acetoacetic acid alkyl ester group esterified with specifically secondary butanol or isobutanol or esterified with two or more different alkanols and is a stable liquid at ambient temperature, or a mixture of such aluminum compounds as a catalyst by a modified or unmodified Carroll reaction.
-
公开(公告)号:AT224348T
公开(公告)日:2002-10-15
申请号:AT98119215
申请日:1998-10-12
Applicant: BASF AG
Inventor: OOST CARSTEN DR , STROEZEL MANFRED , ETZRODT HEINZ DR , BOCKSTIEGEL BERNHARD DR , JAEDICKE HAGEN DR , WELLER DIETMAR DR , LAUPICHLER LOTHAR DR , REIMER KLAUS
Abstract: Preparation of gamma , delta -unsaturated ketones (I) by modified Carroll reaction is catalysed by a stable liquid aluminum acetoacetate compound or mixture of such compounds. Some such catalyst mixtures are new. Preparation of gamma , delta -unsaturated ketones of formula (I) involves modified Carroll reaction of an allyl alcohol of formula (II) with diketene or an alkyl acetoacetate of formula (III) in presence of an aluminum catalyst. R1 = H or 1-20C, saturated or unsaturated, branched hydrocarbyl; R2 = 1-5C alkyl. The novelty is that the catalyst consists of an aluminum compound (or aluminum compound mixture) which is a stable liquid at room temperature and contains at least one alkyl acetoacetate-forming group and 1 or 2 alkoxy groups or exclusively alkyl acetoacetate forming groups which are esterified sec. butanol or isobutanol or with at least two different alkanols. Independent claims are included for: (1) new mixtures of aluminum tris-acetoacetates of formula (V) which are liquid at room temperature; and (2) the preparation of mixtures as in (1). R3 = 1-5C alkyl, preferably Me or Et; R4 = 3-10C alkyl, preferably CHMe2, CH(Me)Et, CMe3 or CH(Me)-C3H7; R5 = 1-10C alkyl, preferably Me, Et, CHMe2, CH(Me)Et or CH(Me)-C3H7; provided that R3-R5 are not all the same. A further Independent claim relates to the continuous preparation of compounds (V) (or their mixtures), having the narrower proviso that R3-R5 can only be the same if they are -CH(Me)Et or -CH2CHMe2, which are liquid at room temperature. The process involves continuously reacting 1 mole of aluminum alcoholate of formula (VI) with 3-10 moles of (III), or with at least 3 moles of a mixture of 2 or 3 different compounds (III), optionally dissolved in an inert solvent. Reaction is at 100-250 (preferably 150-200) degrees C and 1-100 (preferably 1-10) bars with a dwell time of 5-120 (preferably 15-45) minutes, the pressure and temperature being such that no gas phase is formed in the reaction vessel. R6 = 2-10C alkyl, preferably -CH2CHMe2, -CH(Me)Et or -CH(Me)C3H7; provided that R2 and R6 can only be the same if they are -CH(Me)Et or -CH2CHMe2.
-
公开(公告)号:DE4120917A1
公开(公告)日:1993-01-07
申请号:DE4120917
申请日:1991-06-25
Applicant: BASF AG
Inventor: BOCKSTIEGEL BERNHARD DR , EMLING FRANZ DR , KLING ANDREAS DR , JESSEL BARBARA DR , JANSSEN BERND DR
IPC: C07C219/06
Abstract: Described is the use, for the treatment of illnesses, of esters of fatty acids with amino alcohols of the formula I, in which R to R are as defined in the description.
-
公开(公告)号:SI0909750T1
公开(公告)日:2002-12-31
申请号:SI9830255
申请日:1998-10-12
Applicant: BASF AG
Inventor: OOST CARSTEN DR , STROEZEL MANFRED , ETZRODT HEINZ DR , BOCKSTIEGEL BERNHARD DR , JAEDICKE HAGEN DR , WELLER DIETMAR DR , LAUPICHLER LOTHAR DR , REIMER KLAUS
IPC: B01J31/22 , C07C45/67 , C07C49/203 , C07F5/06
-
公开(公告)号:ES2172277T3
公开(公告)日:2002-09-16
申请号:ES99117101
申请日:1999-08-31
Applicant: BASF AG
Inventor: OOST CARSTEN DR , STROEZEL MANFRED , ETZRODT HEINZ DR , WELLER DIETMAR DR , BOCKSTIEGEL BERNHARD DR , REIMER KLAUS
IPC: B01J31/14 , B01D3/00 , B01D3/14 , B01D3/32 , B01J10/00 , B01J19/24 , C07B61/00 , C07C45/67 , C07C45/68 , C07C45/82 , C07C49/203 , C07C67/54 , C07C69/72
Abstract: Continuous production of 5-alken-2-one or 3,5-alkadien-2-one derivatives (I) by reacting a 1-alken-3-ol or 1-alkyn-3-ol derivative (II) with an alkyl acetoacetate (III) in a fractionation column to form an acetoacetate and alcohol involves (i) removing the alcohol and (ii) contacting the acetoacetate with catalyst in the lower part or bottom of the column to form (I). Continuous production of unsaturated ketones of formula (I) by reacting an unsaturated alcohol of formula (II) with an alkyl acetoacetate of formula (III) in the presence of an organoaluminum catalyst is carried out by: (a) reacting (II) with (III) on the plates of a fractionation column to form the acetoacetate of (II) and an alcohol of formula R OH; (b) removing the alcohol in the overhead stream from the column; (c) contacting the acetoacetate of (II) with the catalyst in the lower part or bottom of the column to form (I) and CO2; (d) removing the CO2 in the overhead stream from the column; and (e) withdrawing (I) in the bottoms stream from the column. R = 1-4C alkyl; R = 1-37C (un)saturated aliphatic hydrocarbyl (optionally substituted by methoxy groups), 4-12C cycloalkyl or 5-30C cycloalkylalkyl; and R = 1-5C alkyl.
-
-
-
-
-
-
-
-
-