公开(公告)号：DE3131766A1

公开(公告)日：1983-02-24

申请号：DE3131766

申请日：1981-08-11

Applicant: BASF AG

Inventor： SCHORNICK GUNNAR DR DIPL CHEM ,  JUN MONG-JON DR DIPL CHEM ,  SANNER AXEL DR DIPL CHEM ,  LEHNER AUGUST ING GRAD ,  LENZ WERNER DR DIPL CHEM ,  RICHTER PETER DR DIPL CHEM ,  ECKELL ALBRECHT DR DIPL CHEM

IPC: G03F7/035 ,  C08F299/06 ,  C08G18/66 ,  C08G18/67 ,  G03F7/027 ,  G03F7/032 ,  G03F7/26 ,  G03F7/10 ,  G03C1/70

公开(公告)号：DE2962699D1

公开(公告)日：1982-06-24

申请号：DE2962699

申请日：1979-08-04

Applicant: BASF AG

Inventor： TSCHANG CHUNG-JI DR DIPL CHEM ,  KLEFENZ HEINRICH DR DIPL CHEM ,  SANNER AXEL DR DIPL CHEM

IPC: C08F8/00 ,  C08F8/18 ,  C08F8/28 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F212/08 ,  C08H1/00 ,  C12N11/08 ,  C07G7/00

Abstract: A macroporous crosslinked styrene resin, used as a carrier for covalently binding proteins, which resin contains isocyanate, thioisocyanate or aldehyde groups as protein-binding groups and may or may not contain sulfonic acid groups-which may also be in the form of the sodium salt or of sulfonic acid amide groups-as hydrophilic groups. The carrier according to the invention is prepared from a sulfochlorinated macroporous crosslinked styrene resin by reacting the sulfonic acid chloride groups with an alpha , omega -diamino compound, with hydrazine or with an alpha , omega -diamino-diether, converting any sulfonic acid chloride groups which may still be present to free sulfonic acid groups, their sodium salt or a sulfonamide group, and then reacting the terminal amino groups with phosgene, thiophosgene or a diisocyanate in order to produce the binding groups, which in turn fix a biologically active protein by covalent bonds.