公开(公告)号：JPH11236332A

公开(公告)日：1999-08-31

申请号：JP32070498

申请日：1998-11-11

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  OSTERSEHLT BERND DR ,  WESTENFELDER HORST

IPC: C07D307/62 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/375 ,  A61K47/22 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To use a specific stabilized ascorbic acid derivative useful as an antioxidant for makeup and medicine preparations. SOLUTION: This derivative is shown by formula I (R is H, a 1-20C acyl, a 1-12C alkoxycarbonyl or an alkyl; R is H, a 1-20C acyl, a 1-12C alkoxycarbonyl, an alkyl or the like; R is H, NH4 , an alkali metal action or the like; R is a 1-12C alkoxycarbonyl) such as 2,5,6-tri- O-(isopropyloxycarbonyl)-L-ascoribic acid or the like. The derivative is obtained by reacting an ascorbic acid derivative of formula II with a 1-6C chain length alkyl halocarbonate (e.g. isopropyl chloroformate or the like).

公开(公告)号：JP2000219647A

公开(公告)日：2000-08-08

申请号：JP2000019094

申请日：2000-01-27

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  BURST WOLFRAM ,  JUERGEN DOIVERU ,  JUERGEN KOPPENHOEFER

IPC: C07C29/80 ,  C07C31/22

Abstract: PROBLEM TO BE SOLVED: To produce a highly pure phytantriol useful for cosmetics or the like in high yield without using a heavy metal compound by rectifying a crude phytantriol in a column including a metallic packing material under a specific condition. SOLUTION: Phytantriol obtained by reacting isophytol with performic acid, and saponifying the formed reaction product with an alkaline chemical, and contaminated with byproducts having the lower boiling point and/or the higher boiling point is rectified in a column including a metallic packing material having a regular structure under a moderate vacuum while completely blocking the air under an insulation condition by using an apparatus regulated so that (i) the distribution of a liquid may be carried out by a pass-distributor 6 having >=500 per m2 dropping points, (ii) the passes of the liquid distributor 6 may be arranged so as to form 90 deg. angle to fabric layers of packing material elements 7 and 8 just under the distributor 6, and (iii) two or more fabric layers of the packing material elements having 20-100 mm height may be arranged under the distributor so as to rotate 90 deg. angle to each other.

公开(公告)号：JPH11217380A

公开(公告)日：1999-08-10

申请号：JP32224198

申请日：1998-11-12

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  VON DEM BUSSCHE-HUENNEFELD LIN ,  WESTENFELDER HORST ,  WEKEL HANS-ULRICH DR

IPC: A61K8/00 ,  A61K8/67 ,  A61K31/00 ,  A61K31/375 ,  A61K47/22 ,  A61P17/00 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07D307/62 ,  A61K7/00 ,  A61K7/42 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a ascorbyl sorbate stable against oxidation, giving character istic profiles in a wide range with respect to lipophilicity, and useful as a radical scavenger in the uses of cosmetics and medicines. SOLUTION: This is a compound of formula I [R and R are each hydrogen, a 1-12C alkyl or a 1-20C acryl; R is hydrogen, NH4 or an alkali(ne earth) metal cation], for example, 2,5,6-O-trisobinoyl-L-ascorbic acid. The compound of the formula I is obtained by reacting an ascorbic acid derivative of formula II with sorbic acid or its derivative, especially sorbic chloride, in the presence of a basic catalyst. The compound of the formula I is preferably added to a cosmetic or medicine in an amount of 0.5-5 wt.% based on the total amount of the cosmetic or medicine. The fatty acid esters of trisorbates and vitamin C-2 monosorbate can easily be mixed with ointments, lotions, etc., because of having good oil solubility.

公开(公告)号：JP2001089369A

公开(公告)日：2001-04-03

申请号：JP2000259130

申请日：2000-08-29

Applicant: BASF AG

Inventor： STREICHER HARALD DR

IPC: C07D307/79 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/49 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61P39/06 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07D311/72 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a preparation of a cyclocondensed benzene derivative usable as an antioxidant and/or a radical scavenger in cosmetics or dermatological preparations. SOLUTION: This preparation uses as an antioxidant and/or a radical scavenger in cosmetics, a cyclocondensed benzene derivative expressed by formula I [R1 is H or a 1-12C acyl, R2 is H or 1-12C alkyl, R3 and R4 are each a 1-12C alkyl, R5 and R6 are each H or a 1-12C alkyl, X is -CH2- or -(CH2)2-].

公开(公告)号：JPH10316525A

公开(公告)日：1998-12-02

申请号：JP12341698

申请日：1998-05-06

Applicant: BASF AG

Inventor： WEKEL HANS-ULRICH DR ,  VON DEM BUSSCHE-HUENNEFELD L ,  STREICHER HARALD DR ,  WESTENFELDER HORST

IPC: A61K8/30 ,  A61K8/36 ,  A61K8/365 ,  A61K8/40 ,  A61K8/42 ,  A61K8/60 ,  A61Q17/04 ,  A61Q19/00 ,  C07C273/02 ,  C07C273/18 ,  C07C275/50 ,  C07H13/12 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To make a saccharin acid ureide act as an agent in a cosmetic and impart effects especially on the humectation of skin by using a specific urea derivative as an active ingredient. SOLUTION: A saccharic acid ureide represented by formula I (R is a saccharic acid residue; R is H, an acyl, an alkyl, an alkenyl, a cycloalkenyl, a cycloalkyl or an aryl; R and R are each H, an acyl, an alkyl, an alkenyl, a cycloalkenyl, a cycloalkyl, an aryl or a saccharic acid group) is used especially as a humectant for a cosmetic composition. A part of the compound represented by formula I is new. The compound represented by formula I is obtained by reacting an activated saccharic acid with urea or a urea derivative represented by formula II, as necessary, in the presence of a tertiary base. The amount of the formulated compound represented by formula I is usually 0.1-15 wt.%, advantageously 0.3-5 wt.% in the cosmetic composition.

公开(公告)号：ES2181613T3

公开(公告)日：2003-03-01

申请号：ES00100058

申请日：2000-01-05

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  BURST WOLFRAM ,  DAUWEL JURGEN ,  KOPPENHOFER JURGEN

IPC: C07C29/80 ,  C07C31/22

Abstract: Production of highly pure phytantriol (I) comprises rectification of (I) in a fine vacuum in columns with ordered metal fabric packing and duct distributors with ≥ 500 dripping points/m at an angle of 90 degrees to the layer of fabric just below them. There are 2 or more, 20-100 mm high packing elements with layers of fabric at 90 degrees to one another. Strictly adiabatic rectification with absolute exclusion of air is used. Production of highly pure phytantriol (I) comprises rectification of (I) contaminated with lower and/or higher boiling by-products in a fine vacuum in columns containing metal fabric packing with ordered structure. The liquid is distributed with duct distributors with ≥ 500 dripping points/m . The ducts are at an angle of 90 degrees to the layer of fabric directly below them in the packing. There are 2 or more packing elements with a height of 20-100 mm and layers of fabric at 90 degrees to one another, below the distributor. The process is operated with absolute exclusion of air. Strictly adiabatic rectification is used.

公开(公告)号：DE19750528A1

公开(公告)日：1999-05-20

申请号：DE19750528

申请日：1997-11-14

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  BUSSCHE-HUENNEFELD LINDA VON D ,  WESTENFELDER HORST ,  WEKEL HANS-ULRICH DR

IPC: A61K8/00 ,  A61K8/67 ,  A61K31/00 ,  A61K31/375 ,  A61K47/22 ,  A61P17/00 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07D307/62 ,  A61K7/48 ,  A61K7/42

Abstract: Ascorbyl sorbate derivatives (I) are new. They are prepared by reacting the corresponding ascorbic acid compound with sorbic acid or a corresponding derivative. Ascorbyl sorbate derivatives of formula (I) are new. R1, R2 = H, 1-12C alkyl or 1-20C acyl; or R1+R2 = an optionally substituted heterocycle; R3 = H or a cation selected from NH4 or alkali or alkaline earth metal ions. An Independent claim is also included for preparation of (I).

公开(公告)号：DE19750526A1

公开(公告)日：1999-05-20

申请号：DE19750526

申请日：1997-11-14

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  OESTERSEHLT BERND DR ,  WESTENFELDER HORST

IPC: C07D307/62 ,  A61K8/00 ,  A61K8/49 ,  A61K8/67 ,  A61K31/375 ,  A61K47/22 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48

Abstract: Use of stabilized ascorbic acid derivatives (I) as antioxidants in cosmetics and pharmaceutical compositions, e.g. shampoos, conditioners, mousses, sun creams and moisturizers is claimed. Some of the ascorbic acid derivatives are new and claimed. The use of ascorbic acid derivatives of formula (I) is claimed in cosmetic and pharmaceutical compositions. R1,R2 = H, 1-20C acyl, 1-12C alkoxycarbonyl or 1-12C alkyl; or R1+R2 = an optionally substituted heterocycle; R3 = H or a cation selected from NH4 or alkali or alkaline earth metal ions; R4 = 1-12C alkoxycarbonyl. Independent claims are also included which cover compounds of formula (Ia) and their preparation. R1', R2' = H or 1-20C acyl; or R1'+R2' = C(Me)2; R4' = 1-6C alkoxycarbonyl.

公开(公告)号：ES2272600T3

公开(公告)日：2007-05-01

申请号：ES02008554

申请日：1998-03-17

Applicant: BASF AG

Inventor： KAESLER BRUNO DR ,  MUSCHEN HANS DR ,  STREICHER HARALD DR ,  SAMSON WOLFGANG

IPC: A01N37/02 ,  A23B9/24 ,  A23B9/26 ,  A23B9/28 ,  A23B9/30 ,  A23K30/00 ,  A23K30/15 ,  A23L3/3463 ,  A23L3/3481 ,  A23L3/3508 ,  A23L3/358 ,  C02F1/50

Abstract: Disolución constituida esencialmente por un 78, 0 a un 93, 0 % en peso de ácido propiónico, un 0, 5 a un 5, 0 % en peso de amoniaco, un 1, 0 a un 6, 0 % en peso de propanodiol, un 0, 1 a un 10, 0 % en peso de agua, que contienen adicionalmente hasta un 15 % en peso de al menos otro ácido carboxílico con 1 a 8 átomos de carbono, con la condición de que la suma de componentes aislados se adicione para dar un 100 % en peso.

公开(公告)号：DE59813619D1

公开(公告)日：2006-08-10

申请号：DE59813619

申请日：1998-10-16

Applicant: BASF AG

Inventor： STREICHER HARALD DR ,  OSTERSEHLT BERND DR ,  WESTENFELDER HORST

IPC: A61K8/67 ,  C07D307/62 ,  A61K8/00 ,  A61K8/49 ,  A61K31/375 ,  A61K47/22 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

Abstract: Use of stabilized ascorbic acid derivatives (I) as antioxidants in cosmetics and pharmaceutical compositions, e.g. shampoos, conditioners, mousses, sun creams and moisturizers is claimed. Some of the ascorbic acid derivatives are new and claimed. The use of ascorbic acid derivatives of formula (I) is claimed in cosmetic and pharmaceutical compositions. R1,R2 = H, 1-20C acyl, 1-12C alkoxycarbonyl or 1-12C alkyl; or R1+R2 = an optionally substituted heterocycle; R3 = H or a cation selected from NH4 or alkali or alkaline earth metal ions; R4 = 1-12C alkoxycarbonyl. Independent claims are also included which cover compounds of formula (Ia) and their preparation. R1', R2' = H or 1-20C acyl; or R1'+R2' = C(Me)2; R4' = 1-6C alkoxycarbonyl.