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公开(公告)号:DE3831993A1
公开(公告)日:1990-03-29
申请号:DE3831993
申请日:1988-09-21
Applicant: BASF AG
Inventor: TREIBER HANS-JOERG DR , HOFMANN HANS PETER DR , SZABO LASZLO DR , UNGER LILIANE DR , RASCHACK MANFRED DR
IPC: C07D243/08 , A61K31/495 , A61K31/55 , A61P9/00 , A61P9/08 , A61P9/10 , C07D295/08 , C07D295/084 , C07D295/092
Abstract: 2-hydroxy-3-phenoxy-propyl-substituted piperazines or homopiperazines of formula (I), in which R to R , Y, m and n have the meaning given in the description, and their manufacture are described. The new compounds are useful for treating diseases.
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公开(公告)号:DE19624808A1
公开(公告)日:1998-01-02
申请号:DE19624808
申请日:1996-06-21
Applicant: BASF AG
Inventor: LUBISCH WILFRIED DR , BEHL BERTHOLD DR , HOFMANN HANS-PETER DR , SZABO LASZLO DR
IPC: C07D403/04 , A61K31/495
Abstract: Pyrrolyl quinoxalindiones of formula (I) and their tautomeric and isomeric forms and their physiologically acceptable salts, in which R is hydrogen, C1-C6 alkyl, substituted by hydroxyl or carboxyl, R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, a chlorine, fluorine or bromine atom, a trihalogen methyl, cyano, or nitro group or SO2C1C4 alkyl, R is COOH or a radical hydrolysable to form the carboxyl group, and n is 1 or 2.
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3.
公开(公告)号:CZ9301188A3
公开(公告)日:1994-02-16
申请号:CS118893
申请日:1992-03-05
Applicant: BASF AG
Inventor: TREIBER HANS-JOERG DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/495 , A61P9/00 , A61P9/10 , A61P25/28 , C07D213/57 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/185 , C07D333/24
CPC classification number: C07D295/185 , C07D213/57 , C07D295/155 , C07D333/24
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4.
公开(公告)号:CZ118893A3
公开(公告)日:1994-02-16
申请号:CS118893
申请日:1992-03-05
Applicant: BASF AG
Inventor: TREIBER HANS-JOERG DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/495 , A61P9/00 , A61P9/10 , A61P25/28 , C07D213/57 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/185 , C07D333/24
Abstract: PCT No. PCT/EP92/00488 Sec. 371 Date Sep. 14, 1993 Sec. 102(e) Date Sep. 14, 1993 PCT Filed Mar. 5, 1992 PCT Pub. No. WO92/16516 PCT Pub. Date Oct. 1, 1992.Compounds of the formula I where Ar, R1, R2, P and Q have the meanings indicated in the description, and the preparation thereof are described. The compounds have antihypoxic and antiischemic action and are suitable for treating acute and chronic degenerative processes of the CNS and other organs.
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公开(公告)号:DE4019782A1
公开(公告)日:1992-01-02
申请号:DE4019782
申请日:1990-06-21
Applicant: BASF AG
Inventor: SCHLECKER RAINER DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/135 , A61K31/445 , A61P25/00 , C07C211/41 , C07C215/64 , C07C217/54 , C07C217/74 , C07C317/32 , C07C323/31 , C07D211/14
Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.
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公开(公告)号:DE59103080D1
公开(公告)日:1994-11-03
申请号:DE59103080
申请日:1991-06-07
Applicant: BASF AG
Inventor: SCHLECKER RAINER DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/135 , A61K31/445 , A61P25/00 , C07C211/41 , C07C215/64 , C07C217/54 , C07C217/74 , C07C317/32 , C07C323/31 , C07D211/14
Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.
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公开(公告)号:DK0462468T3
公开(公告)日:1994-10-24
申请号:DK91109388
申请日:1991-06-07
Applicant: BASF AG
Inventor: SCHLECKER RAINER DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/135 , A61K31/445 , A61P25/00 , C07C211/41 , C07C215/64 , C07C217/54 , C07C217/74 , C07C317/32 , C07C323/31 , C07D211/14
Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.
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公开(公告)号:AT112256T
公开(公告)日:1994-10-15
申请号:AT91109388
申请日:1991-06-07
Applicant: BASF AG
Inventor: SCHLECKER RAINER DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/135 , A61K31/445 , A61P25/00 , C07C211/41 , C07C215/64 , C07C217/54 , C07C217/74 , C07C317/32 , C07C323/31 , C07D211/14
Abstract: 9-Amino-2-phenylbicyclo-[3.3.1]nonanes and 9-amino-2-phenylbicyclo[3.3.1]non-2-enes of the formula I I where R1 and R2 are identical or different and each is hydrogen, halogen, alkyl, alkoxy, dialkylamino, trifluoromethyl, hydroxyl, alkylthio, alkylsulfonyl or nitro, R3 and R4 are identical or different and each is hydrogen, alkyl or 1 to 5 or alkenyl or alkynyl of 2 to 5 carbon atoms, or benzyl, it also being possible for R3 and R4 together to form a saturated chain which contains from three to seven carbon atoms and can be substituted by phenyl, and where is a single or double bond, are used for producing drugs which act, in particular, on the central nervous system.
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公开(公告)号:DE4108527A1
公开(公告)日:1992-09-17
申请号:DE4108527
申请日:1991-03-15
Applicant: BASF AG
Inventor: TREIBER HANS-JOERG DR , HOFMANN HANS PETER DR , SZABO LASZLO DR
IPC: A61K31/495 , A61P9/00 , A61P9/10 , A61P25/28 , C07D213/57 , C07D295/14 , C07D295/155 , C07D295/18 , C07D295/185 , C07D333/24
Abstract: Compounds have formula (I), in which Ar, R , R , P and Q have the meanings given in the description. Also disclosed is their production. These compounds are useful for therapeutical purposes.
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