Abstract:
This invention relates to a method for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the method of the invention include plant pyramidine biosynthetic pathway enzymes, and particularly the enzymes involved in the conversion of orotate to uridine-5'-monophosphate (UMP). Further, the invention relates to a method for control of undesirable monocotyledonous and dicotyledenous plant species.
Abstract:
Un objetivo de la presente invencion proveer compuestos que tienen una actividad mejorada para el control de nematodos y acaridos, insectos nocivos y parasitos, para la proteccion del crecimiento y del dano causado por nematodos y ataque de acaridos e infestacion en cultivos cosechados. Proveer un metodo para tratar, controlar, prevenir y proteger animales de sangre caliente, peces y humanos contra la infestacion e infeccion por helmitos, acaridos y artropodos endo y ectoparasitos. Estos objetivos son logrados por los compuestos alqueno di- y tri-fluorosubstituido de formula I. Ademas, hemos encontrado procesos para preparar los compuestos de formula I.
Abstract:
Di- and trifluorosubstituted alkene compounds of formula I wherein X is hydrogen or fluorine; Y is oxygen, NR 1 or S(O) m ; R 1 is hydrogen or C 1 -C 6 -alkyl; m is 0, 1, or 2; A,B,D and E are selected from the following: a) A is N and B, D and E are CR 2 ; or b) B is N and A, D and E are CR 2 ; or c) D is N and A, B, and E are CR 2 ; or d) A and D are N and B and E are CR 2 ; or e) B and E are N and A and D are CR 2 ; R 2 is H, halogen, NH 2 , NO 2 , CN, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,alkylaminoalkyl, dialkylaminoalkyl, hydroxycarbonyl, or alkoxycarbonyl; or phenyl which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; or a 5- to 6-membered heteroaromatic ring system containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; n is 1, 2, 3 or 4, and the agriculturally and/or physiologically tolerable salts thereof, methods for the preparation of compounds I, and compositions and methods for the control of nematodes and arachnids, and for treating, controlling, preventing and protecting warm-blooded animals, fish and humans against infestation and infection by helminths, arachnids and arthropod endo- and ectoparasites.
Abstract:
This invention relates to a method for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the method of the invention include plant pyrimidine biosynthetic pathway enzymes, and particularly the enzymes involved in the conversion of orotate to uridine-5'-monophosphate (UMP). Further, the invention relates to a method for control of undesirable monocotyledenous and dicotyledenous plant species.
Abstract:
Di- and trifluorosubstituted alkene compounds of formula I wherein X is hydrogen or fluorine; Y is oxygen, NR 1 or S(O) m ; R 1 is hydrogen or C 1 -C 6 -alkyl; m is 0, 1, or 2; A,B,D and E are selected from the following: a) A is N and B, D and E are CR 2 ; or b) B is N and A, D and E are CR 2 ; or c) D is N and A, B, and E are CR 2 ; or d) A and D are N and B and E are CR 2 ; or e) B and E are N and A and D are CR 2 ; R 2 is H, halogen, NH 2 , NO 2 , CN, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,alkylaminoalkyl, dialkylaminoalkyl, hydroxycarbonyl, or alkoxycarbonyl; or phenyl which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; or a 5- to 6-membered heteroaromatic ring system containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; n is 1, 2, 3 or 4, and the agriculturally and/or physiologically tolerable salts thereof, methods for the preparation of compounds I, and compositions and methods for the control of nematodes and arachnids, and for treating, controlling, preventing and protecting warm-blooded animals, fish and humans against infestation and infection by helminths, arachnids and arthropod endo- and ectoparasites.
Abstract:
Di- and trifluorosubstituted alkene compounds of formula I wherein X is hydrogen or fluorine; Y is oxygen, NR 1 or S(O) m ; R 1 is hydrogen or C 1 -C 6 -alkyl; m is 0, 1, or 2; A,B,D and E are selected from the following: a) A is N and B, D and E are CR 2 ; or b) B is N and A, D and E are CR 2 ; or c) D is N and A, B, and E are CR 2 ; or d) A and D are N and B and E are CR 2 ; or e) B and E are N and A and D are CR 2 ; R 2 is H, halogen, NH 2 , NO 2 , CN, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,alkylaminoalkyl, dialkylaminoalkyl, hydroxycarbonyl, or alkoxycarbonyl; or phenyl which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; or a 5- to 6-membered heteroaromatic ring system containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; n is 1, 2, 3 or 4, and the agriculturally and/or physiologically tolerable salts thereof, methods for the preparation of compounds I, and compositions and methods for the control of nematodes and arachnids, and for treating, controlling, preventing and protecting warm-blooded animals, fish and humans against infestation and infection by helminths, arachnids and arthropod endo- and ectoparasites.
Abstract:
Compuestos de alqueno di y trisustituidos de fórmula I, en donde X es hidrógeno o fluor; Y es oxígeno, NR1 o S(O)m; R1 es hidrógeno o alquilo C1-C6; m es 0, 1 ó 2; A, B, D y E se seleccionan de lo siguiente: a) A es N y B, D y E son CR2; o d) A y D son N y B y E son CR2, o R2 es hidrógeno, halógeno, amino, nitro, ciano, alquilo C1-C6, haloalquilo C1-C6, alquenilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, alquiltio C1-C6, haloalquiltio C1-C6, alquilsulfinilo C1-C6, haloalquilsulfinilo C1-C6, alquilsulfonilo C1-C6, haloalquilsulfonilo C1-C6, aminosulfonilo, alcoxi C1-C6-alquilo C1-C6, alquiltio C1-C6-alquilo C1-C6, alquilsulfinilo C1-C6-alquilo C1-C6, alquilsulfonilo C1-C6-alquilo C1-C6, alquilamino C1-C6-alquilo C1-C6, dialquilamino C1-C6-alquilo C1-C6, hidroxicarbonilo C1-C6, o alcoxicarbonilo C1-C6; o fenilo que pueda ser sustituido con cualquier combinación de 1 a 5 átomos de halógeno, 1 ó 2 grupos ciano, 1 ó 2 grupos nitro, 1 a 3 grupos alquilo C1-C4, 1 a 4 grupos haloalquilo C1-C4, 1 a 3 grupos alcoxi C1-C4 ó 1 a 3 grupos haloalcoxi C1-C4; o un sistema de anillo heteroaromático de 5 a 6 miembros que contiene de 1 a 3 heteroátomos seleccionados de oxígeno, azufre y nitrógeno, que pueden ser sustituidos con cualquier combinación de 1 a 5 átomos de halógeno, 1 ó 2 grupos ciano, 1 ó 2 grupos nitro, 1 a 3 grupos alquilo C1-C4, 1 a 3 grupos haloalquilo C1-C4, 1 a 3 grupos alcoxi C1-C4 ó 1 a 3 grupos haloalcoxi C1-C4; n es 1, 2, 3 ó 4, y las sales de los mismos tolerables fisiológicamente y/o en agricultura.
Abstract:
Di- and trifluorosubstituted alkene compounds of formula I wherein X is hydrogen or fluorine; Y is oxygen, NR 1 or S(O) m ; R 1 is hydrogen or C 1 -C 6 -alkyl; m is 0, 1, or 2; A,B,D and E are selected from the following: a) A is N and B, D and E are CR 2 ; or b) B is N and A, D and E are CR 2 ; or c) D is N and A, B, and E are CR 2 ; or d) A and D are N and B and E are CR 2 ; or e) B and E are N and A and D are CR 2 ; R 2 is H, halogen, NH 2 , NO 2 , CN, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,alkylaminoalkyl, dialkylaminoalkyl, hydroxycarbonyl, or alkoxycarbonyl; or phenyl which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; or a 5- to 6-membered heteroaromatic ring system containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; n is 1, 2, 3 or 4, and the agriculturally and/or physiologically tolerable salts thereof, methods for the preparation of compounds I, and compositions and methods for the control of nematodes and arachnids, and for treating, controlling, preventing and protecting warm-blooded animals, fish and humans against infestation and infection by helminths, arachnids and arthropod endo- and ectoparasites.
Abstract:
Di- and trifluorosubstituted alkene compounds of formula I wherein X is hydrogen or fluorine; Y is oxygen, NR 1 or S(O) m ; R 1 is hydrogen or C 1 -C 6 -alkyl; m is 0, 1, or 2; A,B,D and E are selected from the following: a) A is N and B, D and E are CR 2 ; or b) B is N and A, D and E are CR 2 ; or c) D is N and A, B, and E are CR 2 ; or d) A and D are N and B and E are CR 2 ; or e) B and E are N and A and D are CR 2 ; R 2 is H, halogen, NH 2 , NO 2 , CN, alkyl, haloalkyl, alkenyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl,alkylaminoalkyl, dialkylaminoalkyl, hydroxycarbonyl, or alkoxycarbonyl; or phenyl which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; or a 5- to 6-membered heteroaromatic ring system containing 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, which may be substituted with halogen, CN, NO 2 , alkyl, haloalkyl, alkoxy, or haloalkoxy; n is 1, 2, 3 or 4, and the agriculturally and/or physiologically tolerable salts thereof, methods for the preparation of compounds I, and compositions and methods for the control of nematodes and arachnids, and for treating, controlling, preventing and protecting warm-blooded animals, fish and humans against infestation and infection by helminths, arachnids and arthropod endo- and ectoparasites.
Abstract:
This invention relates to a method for identifying compounds that specifical ly inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the method of the invention include plant pyramidin e biosynthetic pathway enzymes, and particularly the enzymes involved in the conversion of orotate to uridine-5'-monophosphate (UMP). Further, the invention relates to a method for control of undesirable monocotyledonous an d dicotyledenous plant species.