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    PROCESS FOR THE PREPARATION OF STABLE INJECTABLE BETA-CAROTINE SOLUBILISATE
    1.
    发明专利
    PROCESS FOR THE PREPARATION OF STABLE INJECTABLE BETA-CAROTINE SOLUBILISATE 未知

    公开(公告)号：HU185159B

    公开(公告)日：1984-12-28

    申请号：HU387381

    申请日：1981-12-18

    Applicant: BASF AG

    Inventor： HOPPE PETER P ,  SCHNEIDER JOACHIM U ,  SCHULZ BERNHARD ,  TIEFENBACHER HUBERT

    IPC: A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44 ,  A61K31/015 ,  A61K9/10

    Abstract: A process for the preparation of beta -carotene micellar solutions, wherein a non-ionic emulsifier which is suitable for the preparation of micellar solutions is heated at from 160 DEG to 180 DEG C. and a total of from 20 to 30% by weight, based on the emulsifier, of beta -carotene is introduced in the presence of a conventional antioxidant, the hot homogeneous mixture is cooled rapidly to below 100 DEG C. by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the beta -carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms containing 20-60 oxyethylene units. Parenteral admininstration of the stable beta -carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by beta -carotene deficiency.

    PREPARATION OF A VITAMIN E DRY POWDER
    4.
    发明专利
    PREPARATION OF A VITAMIN E DRY POWDER 未知

    公开(公告)号：CA1119096A

    公开(公告)日：1982-03-02

    申请号：CA327393

    申请日：1979-05-10

    Applicant: BASF AG ,  MEGGLE MILCHIND GMBH & CO

    Inventor： KUIPERS ARIE ,  BECKER HERBERT ,  TIEFENBACHER HUBERT ,  SCHUMACHER HORST

    IPC: A61K31/355

    Abstract: O.Z. 0050/033178 of the disclosure: A vitamin E dry powder, which contains a protein colloid and a disaccharide as carriers, is prepared by dispersing a vitamin E ester in a residual liquor, low in alkaline earth metal ions and rich in lactose, from the production of lactose, in the presence of from 2 to 30 % by weight, based on the solids content of the residual liquor, of a caseinate, and spray-drying the dispersion. The vitamin E dry powder thus prepared is stable, easy to dose and physiologically safe, so that it can be used for any desired purpose.

    STABLE INJECTABLE .beta.-CAROTENE MICELLAR SOLUTIONS AND THEIR PREPARATION
    8.
    发明专利
    STABLE INJECTABLE .beta.-CAROTENE MICELLAR SOLUTIONS AND THEIR PREPARATION 未知

    公开(公告)号：CA1185185A

    公开(公告)日：1985-04-09

    申请号：CA391630

    申请日：1981-12-07

    Applicant: BASF AG

    Inventor： HOPPE PETER P ,  SCHNEIDER JOACHIM U ,  SCHULZ BERNHARD ,  TIEFENBACHER HUBERT

    IPC: A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44 ,  A61K31/23

    Abstract: A process for the preparation of .beta.-carotene micellar solutions, wherein a non-ionic emulsifier which is suitable for the preparation of micellar solutions is heated at from 160 to 180.degree.C and a total of from 20 to 30% by weight, based on the emulsifier, of .beta.-carotene is introduced in the presence of a conventional antioxidant, the hot homogeneous mixture is cooled rapidly to below 100.degree.C by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the .beta.-carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms containing 20 - 60 oxyethylene units. Parenteral administration of the stable .beta.-carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by .beta.-carotene deficiency.

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