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    PRODUCTION OF ALPHA-TOCOPHEROL OR ALPHA-TOCOPHERYL ACETATE
    1.
    发明专利
    PRODUCTION OF ALPHA-TOCOPHEROL OR ALPHA-TOCOPHERYL ACETATE 失效

    公开(公告)号：JPH10195066A

    公开(公告)日：1998-07-28

    申请号：JP35346197

    申请日：1997-12-22

    Applicant: BASF AG

    Inventor： BALDENIUS KAI-UWE ,  KAISER WULF ,  BOCKSTIEGEL BERNHARD ,  LAAS HARALD ,  SCHULZ BERNHARD ,  SCHMITT PETER ,  GLIETENBERG HELMUT

    IPC: B01J27/138 ,  C07D311/72

    Abstract: PROBLEM TO BE SOLVED: To obtain α-tocopherol (vitamin E) important as an antioxidant in the field of nutrition without causing grave waste-water problem from trimethylhydroquinone, etc., by recycling a zinc halide condensation catalyst. SOLUTION: The subject compound is produced by reacting 2,3,5- trimethylhydroquinone with phytol or isophytol in the presence of zinc chloride or zinc bromide and a proton donor such as a mineral acid or toluensulfonic acid. The reaction is carried out in a nonpolar solvent scarcely miscible with water and zinc chloride, etc., are introduced into the reaction system as a mixture of 1mol of the zinc chloride, etc., and 1-4mol of water, separated after the completion of reaction and recycled to the reaction system optionally after concentrating or replenishing to a concentration of about 60-90wt.%.

    STABLE INJECTABLE .beta.-CAROTENE MICELLAR SOLUTIONS AND THEIR PREPARATION
    2.
    发明专利
    STABLE INJECTABLE .beta.-CAROTENE MICELLAR SOLUTIONS AND THEIR PREPARATION 未知

    公开(公告)号：CA1185185A

    公开(公告)日：1985-04-09

    申请号：CA391630

    申请日：1981-12-07

    Applicant: BASF AG

    Inventor： HOPPE PETER P ,  SCHNEIDER JOACHIM U ,  SCHULZ BERNHARD ,  TIEFENBACHER HUBERT

    IPC: A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44 ,  A61K31/23

    Abstract: A process for the preparation of .beta.-carotene micellar solutions, wherein a non-ionic emulsifier which is suitable for the preparation of micellar solutions is heated at from 160 to 180.degree.C and a total of from 20 to 30% by weight, based on the emulsifier, of .beta.-carotene is introduced in the presence of a conventional antioxidant, the hot homogeneous mixture is cooled rapidly to below 100.degree.C by adding water, and the formulation is brought to the desired concentration of from 3 to 6% by weight by adding further water, and the .beta.-carotene micellar solutions obtained by this process. The non-ionic emulsifiers used in this process have an HLB value of from 12 to 16, and are in particular oxyethylated triglycerides of fatty acids of 12 to 18 carbon atoms containing 20 - 60 oxyethylene units. Parenteral administration of the stable .beta.-carotene micellar solutions according to the invention to cattle relieves the disturbed estrus cycle and impaired fertility caused by .beta.-carotene deficiency.

    MANUFACTURE OF SYMMETRICAL CAROTENOIDS
    4.
    发明专利
    MANUFACTURE OF SYMMETRICAL CAROTENOIDS 未知

    公开(公告)号：CA1105875A

    公开(公告)日：1981-07-28

    申请号：CA283093

    申请日：1977-07-19

    Applicant: BASF AG

    Inventor： SCHULZ BERNHARD ,  GRASSNER HANS ,  JAEGER PETER ,  NOHE HEINZ

    IPC: C07F9/54 ,  C09B61/00 ,  C25B3/29 ,  C25B3/02

    Abstract: : Symmetrical carotenoids are manufactured from the molecular halves thereof by a process wherein phosphonium salts of the molecular halves of these symmetrical carotenoids containing as substituents besides said molecular halves three aromatic, aliphatic or cycloaliphatic radicals are oxidized by electrochemical anodic oxidation in a solvent and in the presence of a base at temperatures at from -20 to +60.degree.C with a current density of from 1 to 500A/dm2.

    1,1-DIALKOXY-2-METHYL-4,4-DIACYLOXY-2-BUTENES
    6.
    发明专利
    1,1-DIALKOXY-2-METHYL-4,4-DIACYLOXY-2-BUTENES 未知

    公开(公告)号：CA1291140C

    公开(公告)日：1991-10-22

    申请号：CA541272

    申请日：1987-07-03

    Applicant: BASF AG

    Inventor： SCHULZ BERNHARD ,  FISCHER ROLF

    IPC: C07C67/02 ,  C07C69/007 ,  C07C69/16 ,  C07C69/28 ,  C07C69/78 ,  C07D317/30

    Abstract: 1,1 DIALKOXY-2-METHYL-4,4-DIACYLOXY-2-BUTENES- 1,1-Dialkoxy-2-methyl-4,4-diacyloxy-2-butenes having the general structure: in which R1 represents alkyl substituents having from 1 to 5 carbon atoms, or both R1 substituents together represent a single ethylene or propylene substituent, or a single C1-C2 alkyl substituent, and R2 represents alkyl substituents having from 1 to 5 carbon atoms, or cycloalkyl substituent having from 5 to 7 carbon atoms, or aromatic substituents (preferably phenyl substituents). These new compounds are useful as building blocks in the synthesis of terpenes and carotenoids.

    PREPARATION OF TOCOPHERYL ACETATE AND TOCOPHERYL PROPIONATE
    7.
    发明专利
    PREPARATION OF TOCOPHERYL ACETATE AND TOCOPHERYL PROPIONATE 未知

    公开(公告)号：CA1173842A

    公开(公告)日：1984-09-04

    申请号：CA420769

    申请日：1983-02-02

    Applicant: BASF AG

    Inventor： SCHULZ BERNHARD ,  RENAUER ERICH

    IPC: C07D311/72

    Abstract: PREPARATION OF TOCOPHERYL ACETATE AND TOCOPHERYL PROPIONATE Tocopheryl acetate or tocopheryl propionate is prepared by a process in which trimethylhydroquinone is reacted with phytol or isophytol in the presence of a proton donor and zinc chloride and of a liquid hydrocarbon as the solvent, the tocopherol obtained is then esterified, and the esterification mixture is worked up in a conventional manner to give tocopheryl acetate or tocopheryl propionate, wherein the mixture obtained in the reaction of trimethylhydroquinone with phytol or isophytol is cooled to room temperature, acetic anhydride or propionic anhydride is added and the resulting mixture is heated to 20-60.degree.C or allowed to warm up to this temperature.

    9.
    发明专利
    未知

    公开(公告)号：DE59709492D1

    公开(公告)日：2003-04-17

    申请号：DE59709492

    申请日：1997-12-17

    Applicant: BASF AG

    Inventor： BALDENIUS KAI-UWE ,  KAISER WULF ,  BOCKSTIEGEL BERNHARD ,  LAAS HARALD ,  SCHULZ BERNHARD ,  SCHMITT PETER ,  GLIETENBERG HELMUT

    IPC: B01J27/138 ,  C07D311/72

    Abstract: Preparation of alpha -tocopherol or alpha -tocopheryl acetate comprises reaction of 2,3,5-trimethylhydroquinone (TMH) with phytol or isophytol (IP) in the presence of a zinc halide condensation catalyst and a proton donor, optionally with a final esterification step using acetic anhydride. The reaction involves: (A) a water immiscible or poorly water-miscible non-polar solvent; and (B) 1-4 mole water per mole zinc halide.

    Preparation of alpha-tocopherol or alpha-tocopheryl acetate
    10.
    发明专利
    Preparation of alpha-tocopherol or alpha-tocopheryl acetate 未知

    公开(公告)号：DE19654038A1

    公开(公告)日：1998-06-25

    申请号：DE19654038

    申请日：1996-12-23

    Applicant: BASF AG

    Inventor： BALDENIUS KAI-UWE ,  KAISER WULF ,  BOCKSTIEGEL BERNHARD ,  LAAS HARALD ,  SCHULZ BERNHARD ,  SCHMITT PETER ,  GLIETENBERG HELMUT

    IPC: B01J27/138 ,  C07D311/72

    Abstract: Preparation of alpha -tocopherol or alpha -tocopheryl acetate comprises reaction of 2,3,5-trimethylhydroquinone (TMH) with phytol or isophytol (IP) in the presence of zinc chloride and a proton donor in a water immiscible, or poorly water miscible, nonpolar solvent; and the product is optionally esterified with acetic anhydride. Either (1) the ZnCl2 is used in a mixture with 1-4 moles water per mole ZnCl2; or (2) at the end of reaction, the zinc chloride is separated, preferably by extraction with water or a water/low-boiling solvent mixture; and the zinc chloride solution (optionally concentrated to 60-90 wt.%), is partly or completely returned (optionally as a hot solution or pumpable mash) to the reaction mixture under conditions such that no more than 4 (preferably no more than 3) moles water per mole zinc chloride are available for subsequent reaction.

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