公开(公告)号：JPH02186986A

公开(公告)日：1990-07-23

申请号：JP18067589

申请日：1989-07-14

Applicant: BASF AG

Inventor： MARUKUSU MIYURAA-NOIMAN ,  MARUCHIN SHIYUMITSUTO ,  MARUGAREETE SHIYUBUARUTSU ,  FUERENA BARUDEINGAA ,  TOOMASU DERUPAA ,  KAARUUHERUMAN SUTORUUBE

IPC: C12N9/64 ,  A61K38/46 ,  A61P7/02 ,  C12N9/72 ,  C12N15/57 ,  C12N15/58

公开(公告)号：JPH01230519A

公开(公告)日：1989-09-14

申请号：JP32485288

申请日：1988-12-24

Applicant: BASF AG

Inventor： DEIITAA HERU ,  TOOMASU DERUPAA ,  ROOTAA DAUMU ,  KAARUUHAINTSU GAISU ,  AKIMU MERAA

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12

Abstract: PURPOSE: To obtain a medicine for preventing and treating diseases caused by retroviruses by using polysulfated heparin. CONSTITUTION: Polysulfated heparin having a sulfur content of 13-15% or its salt as an active ingredient, a known preparation carrier, a known excipient, etc., are compounded and subsequently prepared into the objective preparation by a conventional method. The preparation may be prepared in the form of tablets, capsules, powder, granules, injection agents, sprays, etc. The active ingredient is administered orally at a dose of 10-1000mg/Kg or parenterally at a dose of 0.1-10mg/Kg. The polysulfated heparin is obtained by converting heparin into the corresponding pyridinium salt and subsequently polysulfating the pyridinium salt with chlorosulfonic acid in pyridine.

公开(公告)号：JPS63297399A

公开(公告)日：1988-12-05

申请号：JP11371988

申请日：1988-05-12

Applicant: BASF AG

Inventor： TOOMASU DERUPAA ,  AHIMU MERAA ,  HAINTSU HIREN ,  GERUHARUTO KAIRUHAUERU ,  FURANTSU EMURINGU ,  ROOTAA DAUMU

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19

公开(公告)号：JPH01160482A

公开(公告)日：1989-06-23

申请号：JP26625588

申请日：1988-10-24

Applicant: BASF AG

Inventor： UORUFUGANGU KERUBUERU ,  MANFUREETO KURUFUYURUSUTO ,  FUERENA BARUDEINGAA ,  TOOMASU DERUPAA

IPC: A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91

公开(公告)号：JPH01160481A

公开(公告)日：1989-06-23

申请号：JP26625488

申请日：1988-10-24

Applicant: BASF AG

Inventor： UORUFUGANGU KERUBUERU ,  MANFUREETO KURUFUYURUSUTO ,  FUERENA BARUDEINGAA ,  TOOMASU DERUPAA ,  MARUGAREETE SHIYUBUARUTSU

IPC: A61K38/46 ,  A61P7/02 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91

公开(公告)号：JPH01275532A

公开(公告)日：1989-11-06

申请号：JP5805589

申请日：1989-03-13

Applicant: BASF AG

Inventor： ROOTAA DAUMU ,  TOOMASU DERUPAA ,  KAARUUHAINTSU GAISU ,  DEETAA HERU ,  EERITSUHI SHIYURITSUKU

IPC: C12N9/99 ,  A61K31/505 ,  A61K31/52 ,  A61K31/715 ,  A61K38/00 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00

Abstract: PURPOSE: To obtain a medicine for preventing or treating diseases developed by retrovirus, by combining polysulfated heparin with a reverse transcriptase inhibitory substance so as to synergistically potentiate the inhibition of retrovirus replication. CONSTITUTION: This medicine is a combination of polysulfated heparin (pref. sulfur content: 13-16wt.%, molecular weight: 2,000-200,000) with at least one kind selected from (A) reverse transcriptase inhibitory substances such as 3'- azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine, (B) inhibitory substances for retrovirus against binding to host cells (e.g. diphenylhydantoin, monoclonal antibody to T4 -receptor (e.g. OKT4 )), (C) virus biosynthesis inhibitory substances such as avarol and avarone, (D) lymphokines having antiviral activity such as interferon β and tumor necrosis factor a and (E) retinoids such as retinol and all-trans-retinoic acid.

公开(公告)号：JPS635099A

公开(公告)日：1988-01-11

申请号：JP15156987

申请日：1987-06-19

Applicant: BASF AG

Inventor： KURAUSU SHIYORUMAIYAA ,  AKIMU MERAA ,  UORUFUGANGU KERUBUAA ,  TOOMASU DERUPAA

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19