公开(公告)号：JPH07258112A

公开(公告)日：1995-10-09

申请号：JP5468595

申请日：1995-03-14

Applicant: BASF AG

Inventor： ROSUBUIITA SHIYUTENTSUERU ,  ROOTAA DAUMU ,  YURUGEN AIZERUSHIYUTAIN ,  MARUTEIN KAURU ,  YOAHIMU KENPENI

IPC: A61K38/00 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  A61P31/04 ,  A61P37/00 ,  C07K16/24

Abstract: PURPOSE: To obtain an agent containing interleukin-1(IL-1)-antagonist used for treating diseases associated with elevated serum interleukin-6 level. CONSTITUTION: This medicine contains IL-antagonist, e.g. an anti-IL-1-antibody, IL-1-receptor, IL-1-binding protein or IL-1-derivative containing IL-1-receptor, but not exhibiting IL-1 activity. The medicine is used for treating diseases exhibiting elevation of serum interleukin-6 level. The medicine exhibits high therapeutic effect on septic infection patients having IL-6 serum level value (normally

公开(公告)号：JPH0211586A

公开(公告)日：1990-01-16

申请号：JP11239689

申请日：1989-05-02

Applicant: BASF AG

Inventor： ROOTAA DAUMU ,  GERUHARUTO KAIRUHAUAA ,  GIIZERA ROORENTSU ,  EEBERUHARUTO AMUMERUMAN ,  TEIMU ANKE ,  UORUFUGANGU UEEBAA ,  UORUFUGANGU SHIYUTEGURITSUHI ,  BERUTO SHIYUTEFUAN ,  ANGERA SHIEERAA

IPC: C12P17/18 ,  A01N43/90 ,  A61K31/335 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07D493/10 ,  C12R1/645

公开(公告)号：JPH01275532A

公开(公告)日：1989-11-06

申请号：JP5805589

申请日：1989-03-13

Applicant: BASF AG

Inventor： ROOTAA DAUMU ,  TOOMASU DERUPAA ,  KAARUUHAINTSU GAISU ,  DEETAA HERU ,  EERITSUHI SHIYURITSUKU

IPC: C12N9/99 ,  A61K31/505 ,  A61K31/52 ,  A61K31/715 ,  A61K38/00 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00

Abstract: PURPOSE: To obtain a medicine for preventing or treating diseases developed by retrovirus, by combining polysulfated heparin with a reverse transcriptase inhibitory substance so as to synergistically potentiate the inhibition of retrovirus replication. CONSTITUTION: This medicine is a combination of polysulfated heparin (pref. sulfur content: 13-16wt.%, molecular weight: 2,000-200,000) with at least one kind selected from (A) reverse transcriptase inhibitory substances such as 3'- azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine, (B) inhibitory substances for retrovirus against binding to host cells (e.g. diphenylhydantoin, monoclonal antibody to T4 -receptor (e.g. OKT4 )), (C) virus biosynthesis inhibitory substances such as avarol and avarone, (D) lymphokines having antiviral activity such as interferon β and tumor necrosis factor a and (E) retinoids such as retinol and all-trans-retinoic acid.

公开(公告)号：JPH01230519A

公开(公告)日：1989-09-14

申请号：JP32485288

申请日：1988-12-24

Applicant: BASF AG

Inventor： DEIITAA HERU ,  TOOMASU DERUPAA ,  ROOTAA DAUMU ,  KAARUUHAINTSU GAISU ,  AKIMU MERAA

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12

Abstract: PURPOSE: To obtain a medicine for preventing and treating diseases caused by retroviruses by using polysulfated heparin. CONSTITUTION: Polysulfated heparin having a sulfur content of 13-15% or its salt as an active ingredient, a known preparation carrier, a known excipient, etc., are compounded and subsequently prepared into the objective preparation by a conventional method. The preparation may be prepared in the form of tablets, capsules, powder, granules, injection agents, sprays, etc. The active ingredient is administered orally at a dose of 10-1000mg/Kg or parenterally at a dose of 0.1-10mg/Kg. The polysulfated heparin is obtained by converting heparin into the corresponding pyridinium salt and subsequently polysulfating the pyridinium salt with chlorosulfonic acid in pyridine.

公开(公告)号：JPH0195791A

公开(公告)日：1989-04-13

申请号：JP22257488

申请日：1988-09-07

Applicant: BASF AG

Inventor： KURAUSU SHIYORUMAIAA ,  ANDOREASU KURAIMEIYAA ,  ROOTAA DAUMU

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K1/22 ,  C07K14/52 ,  C07K14/525 ,  C07K14/555 ,  C07K14/57 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

公开(公告)号：JPS63297399A

公开(公告)日：1988-12-05

申请号：JP11371988

申请日：1988-05-12

Applicant: BASF AG

Inventor： TOOMASU DERUPAA ,  AHIMU MERAA ,  HAINTSU HIREN ,  GERUHARUTO KAIRUHAUERU ,  FURANTSU EMURINGU ,  ROOTAA DAUMU

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19

公开(公告)号：JPS63264414A

公开(公告)日：1988-11-01

申请号：JP26294087

申请日：1987-10-20

Applicant: BASF AG

Inventor： UERUNAA ZAITSU ,  ROOTAA DAUMU ,  FURANTSU EMURINGU ,  GERUHARUTO KAIRUHAUERU

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00