1.
    发明专利
    未知

    公开(公告)号:DE3583094D1

    公开(公告)日:1991-07-11

    申请号:DE3583094

    申请日:1985-09-10

    Applicant: BASF AG

    Abstract: 2-Amino-3,5-di-(halomethyl)-pyrazines of the general formula I (I) where X is either chlorine or bromine, m and n may each be 0, 1, 2 or 3 and R1 and R2 are each hydrogen or a protective group or may furthermore be bonded to one another, in particular those compounds of the formula I in which m is 1 and n is 2 and/or R1 and R2 together form a phthaloyl radical, are useful intermediates for the pteridine building block of folic acid or folic acid analogs. They are obtained by a method in which a 2-amino-3,5-dimethylpyrazine of the general formula II (II) is treated with a chlorinating or brominating agent and, where R1 and/or R2 are protective groups, these are, if desired, eliminated when the chlorination or bromination is complete.

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