公开(公告)号：NO141897C

公开(公告)日：1980-05-28

申请号：NO743304

申请日：1974-09-13

Applicant: BASF AG

Inventor： AMANN AUGUST ,  BOLZ GERHARD ,  WIERSDORFF WALTER-WIELANT ,  GIERTZ HUBERT ,  WILSMANN KLAUS

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：CA1049023A

公开(公告)日：1979-02-20

申请号：CA208733

申请日：1974-09-09

Applicant: BASF AG

Inventor： AMANN AUGUST ,  BOLZ GERHARD ,  WIERSDORFF WALTER-WIELANT ,  GIERTZ HUBERT ,  WILSMANN KLAUS

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

Abstract: Carbamates derived from polycyclic ?-hydroxylactones and their production. The compounds may be used as pharmaceuticals by virtue of their analgesic properties.

公开(公告)号：NO141897B

公开(公告)日：1980-02-18

申请号：NO743304

申请日：1974-09-13

Applicant: BASF AG

Inventor： AMANN AUGUST ,  BOLZ GERHARD ,  WIERSDORFF WALTER-WIELANT ,  GIERTZ HUBERT ,  WILSMANN KLAUS

IPC: C07D307/77 ,  A61K20060101 ,  A61K31/27 ,  A61K31/34 ,  A61K31/365 ,  C07D20060101 ,  C07D307/89 ,  C07D307/93

公开(公告)号：CA1071644A

公开(公告)日：1980-02-12

申请号：CA286651

申请日：1977-09-13

Applicant: BASF AG

Inventor： AMANN AUGUST ,  BOLZ GERHARD ,  WIERSDORFF WALTER-WIELANT ,  GIERTZ HUBERT ,  WILSMANN KLAUS

IPC: C07D307/77

Abstract: This invention is concerned with a process for the production of a new carbamate of the formula I: I, in which the dotted line denotes a double bond which may be hydrogenated, X is an alkylene bridge of 1 or 2 carbon atoms, R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, R3 is hydrogen and R4 is hydrogen, a linear of branched alkyl of 1 to 4 carbon atoms or a phenyl. This process comprises the steps of reacting a diene of the formula V: V, with a dienophile of the formula VI: VI, according to the Diels Alder reaction, at a temperature of from 15.degree. to 220.degree.C, and hydrogenating the double bond of the obtained unsaturated carbamate when desired. The so prepared new carbamate may be used as pharmaceuticals by virtue of their analgesic properties.