公开(公告)号：WO0119829A2

公开(公告)日：2001-03-22

申请号：PCT/US0025468

申请日：2000-09-15

Applicant: BASF AG ,  HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD LEE D ,  FRIEDMAN MICHAEL M

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD LEE D ,  FRIEDMAN MICHAEL M

IPC: A61K31/519 ,  A61K31/5377 ,  A61K38/22 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P15/16 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561

CPC classification number: C07D487/04 ,  C07F9/6561

Abstract: The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, R3 are defined as described herein.

Abstract translation: 本发明提供式（I）化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2，R 3如本文所述定义。

公开(公告)号：NO20011356A

公开(公告)日：2001-05-16

申请号：NO20011356

申请日：2001-03-16

Applicant: BASF AG

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RITTER KURT ,  ARNOLD LEE DANIEL

IPC: A61K31/519 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561 ,  C07F9/6584 ,  A61K31/505

CPC classification number: C07D487/04 ,  C07F9/6561 ,  C07F9/65842

公开(公告)号：DE60004685D1

公开(公告)日：2003-09-25

申请号：DE60004685

申请日：2000-09-15

Applicant: BASF AG

Inventor： HIRST C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD D ,  FRIEDMAN M

IPC: A61K31/519 ,  A61K31/5377 ,  A61K38/22 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P15/16 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561

Abstract: The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

公开(公告)号：NO20011356L

公开(公告)日：2001-05-16

申请号：NO20011356

申请日：2001-03-16

Applicant: BASF AG

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RITTER KURT ,  ARNOLD LEE DANIEL

IPC: A61K31/519 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561 ,  C07F9/6584 ,  A61K31/505

Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.

公开(公告)号：NO20011356D0

公开(公告)日：2001-03-16

申请号：NO20011356

申请日：2001-03-16

Applicant: BASF AG

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RITTER KURT ,  ARNOLD LEE DANIEL

IPC: A61K31/519 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561 ,  C07F9/6584 ,  C07D

Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.

公开(公告)号：AT247657T

公开(公告)日：2003-09-15

申请号：AT00963554

申请日：2000-09-15

Applicant: BASF AG

Inventor： HIRST GAVIN C ,  CALDERWOOD DAVID ,  WISHART NEIL ,  RAFFERTY PAUL ,  RITTER KURT ,  ARNOLD LEE D ,  FRIEDMAN MICHAEL M

IPC: A61K31/519 ,  A61K31/5377 ,  A61K38/22 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P15/16 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/22 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561 ,  C07D239/00 ,  C07D231/00

Abstract: The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

公开(公告)号：HU0200403A2

公开(公告)日：2002-06-29

申请号：HU0200403

申请日：1999-09-17

Applicant: BASF AG

Inventor： ARNOLD LEE D ,  CALDERWOOD DAVID ,  HIRST GAVIN C ,  RITTER KURT ,  WISHART NEIL

IPC: A61K31/519 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D487/04 ,  C07F9/6561 ,  C07F9/6584

Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.