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公开(公告)号：WO0119828A3
公开(公告)日：2001-10-04
申请号：PCT/US0025357
申请日：2000-09-15
Applicant: BASF AG , HIRST GAVIN C , RAFFERTY PAUL , RITTER KURT , CALDERWOOD DAVID , TWIGGER HELEN L , ST GALLAY STEPHEN
Inventor： HIRST GAVIN C , RAFFERTY PAUL , RITTER KURT , CALDERWOOD DAVID , TWIGGER HELEN L , ST GALLAY STEPHEN
IPC: A61K31/437 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K38/00 , A61P1/18 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , C07D471/04 , C07D487/04 , C07F9/6561 , A61K31/4353 , A61K31/551 , C07D491/04 , C07D498/04
CPC classification number: C07D471/04 , C07D487/04 , C07F9/6561
Abstract: The present invention is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.
Abstract translation: 本发明涉及可用作激酶抑制剂的本文定义的式（I）化合物。
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公开(公告)号：WO0119829A2
公开(公告)日：2001-03-22
申请号：PCT/US0025468
申请日：2000-09-15
Applicant: BASF AG , HIRST GAVIN C , CALDERWOOD DAVID , WISHART NEIL , RAFFERTY PAUL , RITTER KURT , ARNOLD LEE D , FRIEDMAN MICHAEL M
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , WISHART NEIL , RAFFERTY PAUL , RITTER KURT , ARNOLD LEE D , FRIEDMAN MICHAEL M
IPC: A61K31/519 , A61K31/5377 , A61K38/22 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/16 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/22 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D487/04 , C07F9/6561
CPC classification number: C07D487/04 , C07F9/6561
Abstract: The present invention provides compounds of Formula (I), including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, R3 are defined as described herein.
Abstract translation: 本发明提供式（I）化合物，包括其药学上可接受的盐和/或前药，其中G，R a，R 2，R 3如本文所述定义。
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公开(公告)号：NO20011356A
公开(公告)日：2001-05-16
申请号：NO20011356
申请日：2001-03-16
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , WISHART NEIL , RITTER KURT , ARNOLD LEE DANIEL
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
CPC classification number: C07D487/04 , C07F9/6561 , C07F9/65842
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公开(公告)号：SK3842001A3
公开(公告)日：2002-04-04
申请号：SK3842001
申请日：1999-09-17
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , MUNSCHAUER RAINER , RAFFERTY PAUL , ARNOLD LEE D , JOHNSTON DAVID N
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.
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公开(公告)号：CZ2001960A3
公开(公告)日：2001-10-17
申请号：CZ2001960
申请日：1999-09-17
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , MUNSCHAUER RAINER , ARNOLD LEE D , JOHNSTON DAVID N , FAFFERTY PAUL
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.
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Patent Agency Ranking
公开(公告)号：NO20011357L
公开(公告)日：2001-05-14
申请号：NO20011357
申请日：2001-03-16
Applicant: BASF AG
Inventor： CALDERWOOD DAVID , ARNOLD LEE DANIEL , MAZDIYASNI HORMOZ , HIRST GAVIN C , DENG BOJUAN B
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P15/00 , A61P17/02 , A61P19/02 , A61P27/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/04 , A61K31/505
Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferative is a factor. These compounds can be used to treat cancer, hyperproliferation disorders, rheumatoid arthritis, disorders of the immune system, transplant rejection, and inflammatory disorders.
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公开(公告)号：AU7491400A
公开(公告)日：2001-04-17
申请号：AU7491400
申请日：2000-09-15
Applicant: BASF AG
Inventor： HIRST GAVIN C , RITTER KURT , RAFFERTY PAUL , GALLAY STEPHEN ST , CALDERWOOD DAVID
IPC: A61K31/437 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K38/00 , A61P1/18 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , C07D471/04 , C07D487/04 , C07F9/6561 , C07D491/04 , C07D498/04 , A61K31/4353 , A61K31/551 , C07D239/00 , C07D209/00 , C07D237/00 , C07D231/00 , C07D221/00 , C07D243/00
Abstract: The present invention is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.
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公开(公告)号：BG105346A
公开(公告)日：2001-12-31
申请号：BG10534601
申请日：2001-03-15
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , MUNSCHAUER RAINER , ARNOLD LEE D , JOHNSTON DAVID N , RAFFERTY PAUL
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
Abstract: The compounds and their physiologically acceptable salts and metabolites have the formula wherein their substituents have the meanings listed in the description. The compounds are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and inflammatory disorders. 72 claims
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公开(公告)号：TR200101186T2
公开(公告)日：2001-10-22
申请号：TR200101186
申请日：1999-09-17
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , MUNSCHAUER RAINER , ARNOLD LEE D , JOHNSTON DAVID N , RAFFERTY PAUL
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
Abstract: Chemical compounds having structural formula (I) and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatoid arthritis, disorders of the immune system, transplant rejections and imflammatory disorders.
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公开(公告)号：CZ20010960A3
公开(公告)日：2001-10-17
申请号：CZ20010960
申请日：1999-09-17
Applicant: BASF AG
Inventor： HIRST GAVIN C , CALDERWOOD DAVID , MUNSCHAUER RAINER , ARNOLD LEE D , JOHNSTON DAVID N , FAFFERTY PAUL
IPC: A61K31/519 , A61P1/04 , A61P3/10 , A61P5/14 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07D487/04 , C07F9/6561 , C07F9/6584 , A61K31/505
CPC classification number: C07D487/04 , C07F9/6561 , C07F9/65842
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