公开(公告)号：ZA8000166B

公开(公告)日：1981-01-28

申请号：ZA8000166

申请日：1980-01-11

Applicant: BASF AG

Inventor： WORSTMANN W ,  TREIBER H ,  LENKE D

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10 ,  A61K ,  C07D

CPC classification number: C07D267/10

公开(公告)号：DK188680A

公开(公告)日：1980-11-11

申请号：DK188680

申请日：1980-04-30

Applicant: BASF AG

Inventor： STEINER G ,  FRANKE A ,  LENKE D ,  TESCHENDORF H J ,  WORSTMANN W ,  KREISKOTT H

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：YU6680A

公开(公告)日：1983-02-28

申请号：YU6680

申请日：1980-01-11

Applicant: BASF AG

Inventor： TREIBER H ,  LENKE D ,  WORSTMANN W

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10 ,  C07D267/22 ,  A61K31/33

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：ZA8101904B

公开(公告)日：1982-05-26

申请号：ZA8101904

申请日：1981-03-23

Applicant: BASF AG

Inventor： MAY H ,  LENKE D ,  GRIES J ,  TESCHENDORF H ,  WORSTMANN W

IPC: C07D409/06 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K ,  C07D

CPC classification number: C07D233/64

公开(公告)号：DK272080A

公开(公告)日：1980-06-25

申请号：DK272080

申请日：1980-06-25

Applicant: BASF AG

Inventor： TREIBER H J ,  LENKE D ,  WORSTMANN W

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14 ,  C07D

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：ZA8005974B

公开(公告)日：1982-05-26

申请号：ZA8005974

申请日：1980-09-26

Applicant: BASF AG

Inventor： WIERSDORFF W ,  GEISS K ,  WEIFENBACH H ,  WORSTMANN W ,  LENKE D ,  KRETZSCHMAR R

IPC: A61K31/27 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/573 ,  C07C67/00 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07D ,  A61K ,  A61M

CPC classification number: C07D333/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/573 ,  C07D307/14 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  Y10S514/923 ,  C07C49/753

公开(公告)号：ZA8002807B

公开(公告)日：1982-01-27

申请号：ZA8002807

申请日：1980-05-09

Applicant: BASF AG

Inventor： LENKE D ,  STEINER G ,  TESCHENDORF H ,  WORSTMANN W ,  KREISKOTT H ,  FRANKE A

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07C ,  A61K

CPC classification number: C07D223/20

公开(公告)号：ZA795716B

公开(公告)日：1980-11-26

申请号：ZA795716

申请日：1979-10-25

Applicant: BASF AG

Inventor： TREIBER H ,  WORSTMANN W ,  LENKE D

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14 ,  C07D ,  A61K

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：ZA805974B

公开(公告)日：1982-05-26

申请号：ZA805974

申请日：1980-09-26

Applicant: BASF AG

Inventor： WIERSDORFF W ,  GEISS K ,  WEIFENBACH H ,  WORSTMANN W ,  LENKE D ,  KRETZSCHMAR R

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07D ,  A61K ,  A61M

Abstract: Novel carbamates derived from substituted cyclic beta -keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

公开(公告)号：DK406880A

公开(公告)日：1981-03-30

申请号：DK406880

申请日：1980-09-26

Applicant: BASF AG

Inventor： WIERSDORFF W W ,  GEISS K H ,  WEIFENBACH H ,  WORSTMANN W ,  LENKE D ,  KRETZSCHMAR R

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07C

Abstract: Novel carbamates derived from substituted cyclic beta -keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.