公开(公告)号：CA1155859A

公开(公告)日：1983-10-25

申请号：CA360589

申请日：1980-09-19

Applicant: BASF AG

Inventor： WIERSDORFF WALTER-WIELANT ,  GEISS KARL-HEINZ ,  WEIFENBACH HARALD ,  WORSTMANN WOLFGANG ,  LENKE DIETER ,  KRETZSCHMAR ROLF

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07C125/065 ,  C07D333/24 ,  C07D307/54

Abstract: Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their praparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

公开(公告)号：NO147877B

公开(公告)日：1983-03-21

申请号：NO794316

申请日：1979-12-28

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：HU180135B

公开(公告)日：1983-02-28

申请号：HU116080

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：NO802862L

公开(公告)日：1981-03-30

申请号：NO802862

申请日：1980-09-26

Applicant: BASF AG

Inventor： WIERSDORFF WALTER-WIELANT ,  GEISS KARL-HEINZ ,  WEIFENBACH HARALD ,  WORSTMANN WOLFGANG ,  LENKE DIETER ,  KRETZSCHMAR ROLF

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07C

Abstract: Novel carbamates derived from substituted cyclic beta -keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

公开(公告)号：AU5214479A

公开(公告)日：1980-05-01

申请号：AU5214479

申请日：1979-10-24

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：DK150854B

公开(公告)日：1987-07-06

申请号：DK272080

申请日：1980-06-25

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：FI66364B

公开(公告)日：1984-06-29

申请号：FI800057

申请日：1980-01-08

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：AU533524B2

公开(公告)日：1983-12-01

申请号：AU5827080

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：NO149135B

公开(公告)日：1983-11-14

申请号：NO793421

申请日：1979-10-25

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：AU531189B2

公开(公告)日：1983-08-11

申请号：AU5214479

申请日：1979-10-24

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.