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    PRODUCTION OF SOLID PREPARATION
    1.
    发明专利
    PRODUCTION OF SOLID PREPARATION 失效

    公开(公告)号：JP2000128775A

    公开(公告)日：2000-05-09

    申请号：JP29149199

    申请日：1999-10-13

    Applicant: BASF AG

    Inventor： KOTHRADE STEPHAN DR ,  BREITENBACH JOERG DR ,  KRULL HARALD ,  KESSLER THOMAS ,  LANGE ARMIN ,  MAIER WERNER ,  REINHOLD ULRICH

    IPC: A61K9/16 ,  A61K9/20 ,  A61K31/192

    Abstract: PROBLEM TO BE SOLVED: To prepare solid preparations where a high molecular weight polymeric binder can be employed and the delayed release of an active ingredient is made possible by producing a plastic mixture of a specific polymeric binder, medicament active principle or the like under a specific condition and by molding the mixture so as to have a necessary dosage form. SOLUTION: The objective preparations are prepared by producing a plastic mixture of at least one kind selected from pharmaceutically acceptable polymeric binders having >75 K value (preferably homopolymer or a copolymer from vinylpyrrolidone) and at least one kind selected from medicament active principles, (e.g. ibuprofen or the like) and, optionally, a customary adjuvant under the condition of temperature (preferably

    MANUFACTURE OF AT LEAST TWO-PHASE SOLID BLENDED MEDICINE SHAPE AND THIS BLENDED MEDICINE SHAPE
    2.
    发明专利
    MANUFACTURE OF AT LEAST TWO-PHASE SOLID BLENDED MEDICINE SHAPE AND THIS BLENDED MEDICINE SHAPE 失效

    公开(公告)号：JPH10314279A

    公开(公告)日：1998-12-02

    申请号：JP6095798

    申请日：1998-03-12

    Applicant: BASF AG

    Inventor： ZEIDLER JUERGEN DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR ,  KLEINKE ANDREAS DR ,  MAIER WERNER

    IPC: A61J3/10 ,  A61K9/20 ,  A61K47/26 ,  A61K47/30 ,  B30B11/16

    Abstract: PROBLEM TO BE SOLVED: To manufacture a solid blended medicine shape in a large variation width by housing a solid preparation in a plastic material, and containing a single active substance in melt and/or the preparation when a medicine shape is molded from the melt composed of a high molecular weight binding agent. SOLUTION: Melt composed of a high molecular weight binding agent (for example, alkyl cellulose, hydroxyalkyl cellulose or the like) and an-active substance is molded. When this is molded, a single solid preparation containing the active substance is put in a plastic material. In a molding process, metal mold rollers 1 and 2 are rotated in the opposite direction, and a strand 3 from an extruder is composed of an active substance containing high molecular weight binding agent, and is sent into the two rollers 1 and 2 in the arrow direction. At the same time, melt composed of an active substance containing high molecular weight binding agent B is sent into a recess of the roller 1 from a supply device 4. Since the roller 1 is cooled, the melt immediately coagulates. A tablet is punched from the strand 3 by opposite directional rotation of the rollers 1 and 2.

    8.
    发明专利
    未知

    公开(公告)号：ES2135790T3

    公开(公告)日：1999-11-01

    申请号：ES95943203

    申请日：1995-12-22

    Applicant: BASF AG

    Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JORG

    IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

    Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

    METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING
    10.
    发明专利
    METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING 未知

    公开(公告)号：HUT77625A

    公开(公告)日：1998-06-29

    申请号：HU9800064

    申请日：1995-12-22

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG ,  MAIER WERNER ,  ROSENBERG JOERG

    IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

    Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

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