公开(公告)号：WO2004106407A1

公开(公告)日：2004-12-09

申请号：PCT/EP2004/005927

申请日：2004-06-02

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： KLUMPE, Markus ,  BALDENIUS, Kai-Uwe ,  HACKMANN, Claus ,  LAUTERBACH, Arnulf ,  SEELMANN-EGGEBERT, Hans-Peter ,  ZIPPLIES, Matthias

IPC: C08G65/30

CPC classification number: C08G65/30 ,  C08G65/2609

Abstract: Die vorliegende Erfindung beschreibt ein Verfahren zur Reinigung von durch Addition von Alkylenoxid an Alkylenglykol erhaltene Polyalkylenglykole, wobei nach erfolgter Addition das erhaltene Polyalkylenglykol bei einem pH-Wert von > 7 mit einem Bleichmittel aus der Gruppe der Peroxide, Persäuren, Percarbonate, Perborate, Peroxidsulfate oder Sauerstoff, jeweils gegebenenfalls unter Zusatz eines Bleichaktivators behandelt wird.Das Verfahren eignet sich insbesondere zur Herstellung von Polyethylenglykol mit Molgewichten von 196 bis 203 g/mol, das Arzneibuchanforderungen erfüllt.

Abstract translation: 本发明描述了用于纯化的方法通过将氧化烯与亚烷基二醇得到的聚亚烷基二醇，加入后，在与选自过氧化物，过酸，过碳酸盐，过硼酸盐的，Peroxidsulfate或漂白剂的pH值> 7的聚亚烷基二醇 The用加入漂白活化剂的方法任选地经过处理的每个氧特别适合于生产具有从196至203克/摩尔，以满足药典要求的分子量的聚乙二醇。

公开(公告)号：EP1633798A1

公开(公告)日：2006-03-15

申请号：EP04735738.9

申请日：2004-06-02

Applicant: BASF Aktiengesellschaft

Inventor： KLUMPE, Markus ,  BALDENIUS, Kai-Uwe ,  HACKMANN, Claus ,  LAUTERBACH, Arnulf ,  SEELMANN-EGGEBERT, Hans-Peter ,  ZIPPLIES, Matthias

IPC: C08G65/30

CPC classification number: C08G65/30 ,  C08G65/2609

Abstract: The invention relates to a method for purifying polyalkylene glycols obtained by adding alkylene oxide to alkylene glycol, whereby after addition, the polyalkylene glycol is treated at a pH value of > 7 with a bleaching agent from the group consisting of peroxide, peracids, percarbonates, perborates, peroxide sulfates or oxygen, optionally using a bleach activator. The method is particularly useful for the production of polyethylene glycol with molecular weights ranging from 196 to 203 g/mol, complying with pharmacopoeial requirements.

公开(公告)号：EP0871691A1

公开(公告)日：1998-10-21

申请号：EP96933342.0

申请日：1996-09-20

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： DRALLE-VOSS, Gabriele ,  STÖSSER, Michael ,  LANG, Siegfried ,  SAUPE, Thomas ,  ZIPPLIES, Matthias

IPC: A61K47 ,  C07C67 ,  C07C69 ,  C11B3 ,  C11C3

CPC classification number: C11B3/10 ,  A61K47/44 ,  C07C67/56

Abstract: A process for purifying alkoxylated fats by treatment with a solid substance, characterized in that the solid substance used is a mixture of aluminium oxide and a silicate.

公开(公告)号：EP1633798B1

公开(公告)日：2007-01-03

申请号：EP04735738.9

申请日：2004-06-02

Applicant: BASF Aktiengesellschaft

Inventor： KLUMPE, Markus ,  BALDENIUS, Kai-Uwe ,  HACKMANN, Claus ,  LAUTERBACH, Arnulf ,  SEELMANN-EGGEBERT, Hans-Peter ,  ZIPPLIES, Matthias

IPC: C08G65/30

CPC classification number: C08G65/30 ,  C08G65/2609

Abstract: The invention relates to a method for purifying polyalkylene glycols obtained by adding alkylene oxide to alkylene glycol, whereby after addition, the polyalkylene glycol is treated at a pH value of > 7 with a bleaching agent from the group consisting of peroxide, peracids, percarbonates, perborates, peroxide sulfates or oxygen, optionally using a bleach activator. The method is particularly useful for the production of polyethylene glycol with molecular weights ranging from 196 to 203 g/mol, complying with pharmacopoeial requirements.

公开(公告)号：EP0871691B1

公开(公告)日：2003-04-23

申请号：EP96933342.6

申请日：1996-09-20

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： DRALLE-VOSS, Gabriele ,  STÖSSER, Michael ,  LANG, Siegfried ,  SAUPE, Thomas ,  ZIPPLIES, Matthias

IPC: C11B3/10 ,  C11C3/00 ,  A61K47/44

CPC classification number: C11B3/10 ,  A61K47/44 ,  C07C67/56

Abstract: A process for purifying alkoxylated fats by treatment with a solid substance, characterized in that the solid substance used is a mixture of aluminium oxide and a silicate.

公开(公告)号：EP0641324A1

公开(公告)日：1995-03-08

申请号：EP93909981.0

申请日：1993-05-13

Applicant: BASF Aktiengesellschaft

Inventor： HELLENDAHL, Beate ,  SCHLECKER, Rainer ,  ROEHL, Franz ,  ZIPPLIES, Matthias ,  RASCHACK, Manfred ,  HAFNER, Matthias

IPC: A61K31 ,  A61P9 ,  A61P31 ,  C07D217

CPC classification number: C07D217/06 ,  A61K31/47 ,  C07D217/04

Abstract: Medicament for oral administration which contains as active substance per individual dose, besides the customary galenic auxiliaries, 10 to 1000 mg of a compound of general formula (I) or (II) in which W is a carbonyl group or a single bond, R1 is a hydrogen atom or a group of the general formula R3CO in which R3 is a lower alkyl, lower alkoxy, mono lower alkylamino or di lower alkylamino group, R2 is an alkyl residue with 3 to 20 carbon atoms which may be branched or unbranched and contain 1 to 3 double bonds, a saturated cycle of 3 to 7 carbon atoms integrated into the chain or as substituent, or may be substituted by one or more aromatic rings or contain an oxygen or sulphur atom, as a racemate and as isolated enantiomers; or the addition salt thereof with a physiologically acceptable acid, and the active substances themselves insofar as they are novel.