公开(公告)号：ES2381872T3

公开(公告)日：2012-06-01

申请号：ES03796081

申请日：2003-12-03

Applicant: BASF SE

Inventor： HAASE JUERG ,  EHLIS THOMAS ,  BORSOS ELEK ,  MUELLER STEFAN

IPC: C07C229/52 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D295/18 ,  C07D295/192 ,  C07D313/12

Abstract: Compuesto de la fórmula en forma micronizada que tiene un tamaño de partícula de 0.02 a 2 micrómetros, en donde R1 y R2 independientemente uno del otro son un alquilo C1-C20; alquenilo C2-C20; cicloalquilo C3-C10; cicloalquenilo C3-C10; o R1 y R2 juntos con el átomo de nitrógeno que los une forman, un anillo heterocíclico de 5- o 6- miembros; n1 es 1 o 2; cuando n1 = 1, R3 es un radical heterocíclico saturado o insaturado; cuando n1 es 2, R3 es un radical alquileno-, cicloalquileno, alquenileno o fenileno, el cual es opcionalmente sustituido por un grupo carbonilo o carboxi; un radical de la fórmula *-CH2-C≡C-CH2-* o R3 junto con A forman un radical bivalente de la fórmula (1a) en donde n2 es un número de 1 a 3. A es -O-; o -N(R5)-; y R5 es hidrógeno; alquilo C1-C5; o hidroxi-alquilo C1-C5.

公开(公告)号：AT553076T

公开(公告)日：2012-04-15

申请号：AT03796081

申请日：2003-12-03

Applicant: BASF SE

Inventor： HAASE JUERG ,  EHLIS THOMAS ,  BORSOS ELEK ,  MUELLER STEFAN

IPC: C07C229/52 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D295/18 ,  C07D295/192 ,  C07D313/12

Abstract: Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R 1 , and R 2 independently from each other are; C 1 -C 20 alkyl; C 2 -C 20 -alkenyl; C 3 -C 10 cycloalkyl; C 3 -C 10 cycloalkenyl; or R 1 , and R 2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n 1 is a number from 1 to 4; when n 1 =1, R 3 is a saturated or unsaturated heterocyclic radical; hydroxy-C 1 -C 5 alkyl; cyclohexyl optionally substituted with one or more C 1 -C 5 alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C 1 -C 5 alkylcarboxy; when n 1 is 2, R 3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R 3 together with A forms a bivalent radical of the formula (Ia), wherein n 2 is a number from 1 to 3; when n 1 is 3, R 3 is an alkanetriyl radical; when n 1 is 4, R 3 is an alkanetetrayl radical; A is -O-; or -N(R 5 )-; and R 5 is hydrogen; C 1 -C 5 alkyl; or hydroxy-C 1 -C 5 alkyl. The compounds are useful as UV filters in sunscreen applications.

公开(公告)号：BRPI0810776A2

公开(公告)日：2014-10-07

申请号：BRPI0810776

申请日：2008-04-28

Applicant: BASF SE

Inventor： VOGT MARTIN ,  MUELLER STEFAN ,  GRUMELARD JULIE ,  DESHAYES CYRILLE ,  PAUL HOLGER ,  HAASE JUERG ,  EHLIS THOMAS

IPC: A61K8/49 ,  A61Q17/04 ,  A61Q19/08

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.