公开(公告)号：WO2009007264A3

公开(公告)日：2009-09-03

申请号：PCT/EP2008058356

申请日：2008-06-30

Applicant: BASF SE ,  MUELLER STEFAN ,  LINDEMANN BRIGITTE ,  HERZOG BERND

Inventor： MUELLER STEFAN ,  LINDEMANN BRIGITTE ,  HERZOG BERND

IPC: A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/44 ,  A61K8/49 ,  A61K8/81 ,  A61Q17/04

CPC classification number: A61Q17/04 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/44 ,  A61K8/445 ,  A61K8/496 ,  A61K8/4966 ,  A61K8/585 ,  A61K8/8152 ,  A61K8/893 ,  A61K2800/413

Abstract: The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

Abstract translation: 本发明涉及使用平均粒径小于1000nm的浓缩水性聚合物分散体，其包含（a）通过至少一种烯属不饱和单体的异相自由基聚合制备的聚合物载体，所述聚合物载体在（b） 选自对氨基苯甲酸衍生物类的油溶性有机UV吸收剂; 水杨酸衍生物; 二苯甲酮衍生物; 二苯基丙烯酸酯衍生物; 苯并呋喃衍生物; 包含一个或多个有机硅基团的聚合物UV吸收剂; 肉桂酸衍生物; 樟脑衍生物 三嗪衍生物; 三苯胺三嗪衍生物; 薄荷基邻氨基苯甲酸酯; 和苯并三唑衍生物; 其中油溶性有机UV吸收剂（b）与聚合物载体（a）的重量比相对于100份载体大于50份UV吸收剂; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。 浓缩的水性聚合物分散体表现出意想不到的高防晒效果和阳性皮肤感觉。

公开(公告)号：ES2381872T3

公开(公告)日：2012-06-01

申请号：ES03796081

申请日：2003-12-03

Applicant: BASF SE

Inventor： HAASE JUERG ,  EHLIS THOMAS ,  BORSOS ELEK ,  MUELLER STEFAN

IPC: C07C229/52 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D295/18 ,  C07D295/192 ,  C07D313/12

Abstract: Compuesto de la fórmula en forma micronizada que tiene un tamaño de partícula de 0.02 a 2 micrómetros, en donde R1 y R2 independientemente uno del otro son un alquilo C1-C20; alquenilo C2-C20; cicloalquilo C3-C10; cicloalquenilo C3-C10; o R1 y R2 juntos con el átomo de nitrógeno que los une forman, un anillo heterocíclico de 5- o 6- miembros; n1 es 1 o 2; cuando n1 = 1, R3 es un radical heterocíclico saturado o insaturado; cuando n1 es 2, R3 es un radical alquileno-, cicloalquileno, alquenileno o fenileno, el cual es opcionalmente sustituido por un grupo carbonilo o carboxi; un radical de la fórmula *-CH2-C≡C-CH2-* o R3 junto con A forman un radical bivalente de la fórmula (1a) en donde n2 es un número de 1 a 3. A es -O-; o -N(R5)-; y R5 es hidrógeno; alquilo C1-C5; o hidroxi-alquilo C1-C5.

公开(公告)号：AT553076T

公开(公告)日：2012-04-15

申请号：AT03796081

申请日：2003-12-03

Applicant: BASF SE

Inventor： HAASE JUERG ,  EHLIS THOMAS ,  BORSOS ELEK ,  MUELLER STEFAN

IPC: C07C229/52 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D295/18 ,  C07D295/192 ,  C07D313/12

Abstract: Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R 1 , and R 2 independently from each other are; C 1 -C 20 alkyl; C 2 -C 20 -alkenyl; C 3 -C 10 cycloalkyl; C 3 -C 10 cycloalkenyl; or R 1 , and R 2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n 1 is a number from 1 to 4; when n 1 =1, R 3 is a saturated or unsaturated heterocyclic radical; hydroxy-C 1 -C 5 alkyl; cyclohexyl optionally substituted with one or more C 1 -C 5 alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C 1 -C 5 alkylcarboxy; when n 1 is 2, R 3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R 3 together with A forms a bivalent radical of the formula (Ia), wherein n 2 is a number from 1 to 3; when n 1 is 3, R 3 is an alkanetriyl radical; when n 1 is 4, R 3 is an alkanetetrayl radical; A is -O-; or -N(R 5 )-; and R 5 is hydrogen; C 1 -C 5 alkyl; or hydroxy-C 1 -C 5 alkyl. The compounds are useful as UV filters in sunscreen applications.

公开(公告)号：ES2435512T3

公开(公告)日：2013-12-20

申请号：ES04721908

申请日：2004-03-19

Applicant: BASF SE

Inventor： EHLIS THOMAS ,  MUELLER STEFAN ,  HAYOZ PASCAL

IPC: C07D251/24 ,  A61K8/49 ,  A61Q17/04

Abstract: Uso de los compuestos de fórmula **Fórmula** en donde R1 y R5 independientemente entre sí son hidrógeno; R6, R7 y Re independientemente entre sí son hidrógeno; hidroxilo; halógeno; alquilo C1 - C18; alcoxi C1 - C168; arilo C6- C12; bifenilo; ariloxi C6 - C12; alquiltio C1 - C16; carboxilo; -COOM; alquilcarboxilo C1 - C18; aminocarbonilo; o mono odialquilamino C1 - C16; acilamino C1 - C10, -COOH; y M es un ion de metal alcalino; en donde el compuesto de fórmula (2) está presente en la composicion en el estado micronizado; para la protecciónde piel y cabello humano o de animal contra el efecto nocivo de la radiación UV.

公开(公告)号：BRPI0810776A2

公开(公告)日：2014-10-07

申请号：BRPI0810776

申请日：2008-04-28

Applicant: BASF SE

Inventor： VOGT MARTIN ,  MUELLER STEFAN ,  GRUMELARD JULIE ,  DESHAYES CYRILLE ,  PAUL HOLGER ,  HAASE JUERG ,  EHLIS THOMAS

IPC: A61K8/49 ,  A61Q17/04 ,  A61Q19/08

Abstract: Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.

公开(公告)号：BRPI0812845A2

公开(公告)日：2014-12-09

申请号：BRPI0812845

申请日：2008-06-27

Applicant: BASF SE

Inventor： MUELLER STEFAN ,  HERZOG BERND

IPC: C07D251/24 ,  A61K8/49

Abstract: Disclosed is a method of preparing a composition, comprising a micronized insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus comprising yttrium-stabilized zirconium oxide grinding beads, in the presence of alkyl polyglucoside having the formula CnH2n+1O(C6H10O5)xH, in which n is an integer ranging from 8 to 16 and x is the mean polymerisation level of the glucoside moiety (C6H10O5) and ranges from 1.4 to 1.6, or an ester thereof and in the presence of an antifoam agent as dispersingagent auxiliary.

公开(公告)号：ES2398672T3

公开(公告)日：2013-03-20

申请号：ES08707930

申请日：2008-01-16

Applicant: BASF SE

Inventor： WAGNER BARBARA ,  HERZOG BERND ,  MUELLER STEFAN ,  EHLIS THOMAS

IPC: A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61Q17/04

Abstract: Uso de los derivados de merocianina de fórmula **Fórmula** en donde L1, L2 o L3 independientemente uno del otro son hidrógeno; hidroxi; alquilo C1-C22; alcoxi C1-C22; alquenilo C2-C22: alquinilo C2-C22; cicloalquilo C3-C12; cicloalquenilo C3-C12; aralquilo C7-C20; heteroalquilo C1-C20; ciclo heteroalquilo C3-C12, heteroaralquilo C4-C20; arilo C6-C18; R4 es CN; -COR5; -COOR6; -CONR5R6; alquenilo C2-C22; alquinilo C2-C22; cicloalquenilo C3-C12; arilo C8-C18; heteroarilo C3- C12; heteroalquilo C2- C12; o heterocicloalquilo C3-C5.

公开(公告)号：DE602006011154D1

公开(公告)日：2010-01-28

申请号：DE602006011154

申请日：2006-04-20

Applicant: BASF SE

Inventor： MUELLER STEFAN ,  GIESINGER JOCHEN ,  EHLIS THOMAS ,  HERZOG BERND ,  KOENIG PETER ,  KREYER GILBERT ,  QUASS KATJA

IPC: A61K8/49 ,  A61Q17/04

Abstract: Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.

公开(公告)号：AT451910T

公开(公告)日：2010-01-15

申请号：AT06777204

申请日：2006-04-20

Applicant: BASF SE

Inventor： MUELLER STEFAN ,  GIESINGER JOCHEN ,  EHLIS THOMAS ,  HERZOG BERND ,  KOENIG PETER ,  KREYER GILBERT ,  QUASS KATJA

IPC: A61K8/49 ,  A61Q17/04

Abstract: Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.