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    METHOD FOR PREPARING A FERMENTATION MEDIUM
    1.
    发明申请
    METHOD FOR PREPARING A FERMENTATION MEDIUM 审中-公开

    公开(公告)号：WO2021001297A1

    公开(公告)日：2021-01-07

    申请号：PCT/EP2020/068199

    申请日：2020-06-29

    Applicant: BASF SE

    Inventor： KAEDING, Thomas ,  HAGE, Kerstin ,  HAM-ZHU, Rodolfo

    IPC: C12P21/02 ,  C12N1/20

    Abstract: The present invention is directed to a method of preparing a fermentation medium comprising the steps of a) mixing components of a fermentation medium comprising a complex nutrient source in water, wherein the complex nutrient source is in an amount of 0.5-30% w/v of the fermentation medium; b) adjusting the pH of the fermentation medium obtained in step a) to a pH between pH 3.0 and pH 6.7; c) subjecting the fermentation medium subsequently to a heat treatment and thereafter adjusting the pH to a pH value suitable for cell cultivation. The present invention is further directed to a method a fermentation process comprising cultivation of the cells in the fermentation medium of the invention and the production of a compound of interest. The present invention is further directed to a method for reducing color formation and viscosity during fermentation medium preparation and during the fermentation process.

    FERMENTATION MEDIUM COMPRISING CHELATING AGENT
    3.
    发明申请
    FERMENTATION MEDIUM COMPRISING CHELATING AGENT 审中-公开
    包含螯合剂的发酵培养基

    公开(公告)号：WO2018011242A1

    公开(公告)日：2018-01-18

    申请号：PCT/EP2017/067474

    申请日：2017-07-12

    Applicant: BASF SE

    Inventor： HAGE, Kerstin ,  SCHWALB, Carsten ,  STEIGELMANN, Gunter ,  KAEDING, Thomas ,  BRIECHLE, Sebastian

    IPC: C12N1/20 ,  C12N1/14 ,  C12N1/18 ,  C12N1/16 ,  C12N1/00 ,  C12N1/38 ,  C12N5/00

    Abstract: The present invention is directed to a fermentation medium and a fermentation method using said fermentation medium wherein the fermentation medium comprising a basal medium and a chelating agent having the formula (I) R 1 -CH(COOX 1 )-N(CH 2 COOX 1 ) 2 , wherein R 1 is selected from hydrogen, linear or branched C 1 -C 4 -alkyl, phenyl, benzyl, CH 2 OH, and CH 2 CH 2 COOX 1 , X 1 is (Μ x Η 1-x ), M being a monovalent cation, preferably being selected from ammonium or alkali metal or combinations of at least two of the foregoing, x is in the range of from zero to 1, wherein x is an average value.

    Abstract translation: 本发明涉及发酵培养基和使用所述发酵培养基的发酵方法，其中发酵培养基包含基础培养基和具有式（I）R1的螯合剂， -CH（COOX 1）-N（CH 2）COOX 1）2，其中R 1选自氢，直链或支链C 1 -C 4 - 烷基，苯基，苄基，CH 2 OH ，并且CH 2 = CH 2 COOX 1，X 1是（M x = H是1价阳离子，优选选自铵或碱金属或前述至少两种的组合，x在0-1的范围内，其中x 是一个平均值。

    METHOD FOR REMOVING ANTIFOAMING AGENTS FROM A FERMENTATION BROTH
    4.
    发明申请
    METHOD FOR REMOVING ANTIFOAMING AGENTS FROM A FERMENTATION BROTH 审中-公开

    公开(公告)号：WO2022049228A1

    公开(公告)日：2022-03-10

    申请号：PCT/EP2021/074332

    申请日：2021-09-03

    Applicant: BASF SE

    Inventor： SCHOOF, Sebastian ,  KAEDING, Thomas ,  MUENKEL, Ronja

    IPC: C12P21/02 ,  C12N1/00

    Abstract: The present invention relates to a method for separating a molecule of interest from an antifoaming agent in a fermentation broth comprising said molecule of interest and said antifoaming agent. The method comprises the steps of filtering the fermentation broth at a temperature in the range of 1 °C to 15 °C above the cloud point of the antifoaming agent, and thereby obtaining a first fraction of the fermentation broth comprising the molecule of interest and a second fraction of the fermentation broth comprising the antifoaming agent, wherein the antifoaming agent is a polyalkylene glycol based antifoaming agent. The invention further relates to a process for purifying a molecule of interest from a fermentation broth comprising said method.

    METHOD OF PURIFYING A PROTEIN FROM FERMENTATION SOLIDS UNDER DESORBING CONDITIONS
    6.
    发明申请
    METHOD OF PURIFYING A PROTEIN FROM FERMENTATION SOLIDS UNDER DESORBING CONDITIONS 审中-公开
    从发酵固体在解吸条件下纯化蛋白质的方法

    公开(公告)号：WO2017097869A1

    公开(公告)日：2017-06-15

    申请号：PCT/EP2016/080165

    申请日：2016-12-08

    Applicant: BASF SE

    Inventor： TREIER-MARXEN, Katrin ,  DECKERT, Petra ,  SCHAEDLER, Andreas ,  NAVICKAS, Vaidotas ,  WENGERT, Volker ,  KAEDING, Thomas

    IPC: B01D61/16 ,  C12N1/02 ,  C07K1/14

    CPC classification number: C12N1/02 ,  B01D61/147 ,  B01D61/16 ,  B01D2311/04 ,  B01D2311/18 ,  B01D2315/16 ,  C07K1/145 ,  C12P21/02

    Abstract: The present invention is directed to a method of purifying a protein of interest from the particulate matter of a fermentation broth comprising the step of purifying the protein of interest from the particulate matter of the fermentation broth, wherein the step of purifying the protein of interest from the particulate matter of the fermentation broth comprises one or more washing steps, which comprises contacting the particulate matter with a washing solution comprising one or more conditions that favor the solubilization of the protein of interest and/or the desorption of the protein of interest from the particulate matter.

    Abstract translation: 本发明涉及从发酵液微粒物质中纯化感兴趣的蛋白质的方法，其包括从发酵液微粒物质中纯化感兴趣的蛋白质的步骤，其中所述 从发酵液的颗粒物质中纯化感兴趣的蛋白质的步骤包括一个或多个洗涤步骤，该步骤包括使颗粒物质与洗涤溶液接触，所述洗涤溶液包含一个或多个有利于感兴趣的蛋白质和/或 目标蛋白质从颗粒物质中解吸。

    PRODUCTION OF PYRIPYROPENES FROM DRY BIOMASS
    7.
    发明申请
    PRODUCTION OF PYRIPYROPENES FROM DRY BIOMASS 审中-公开
    从干生物量生产吡啶酮

    公开(公告)号：WO2014155214A1

    公开(公告)日：2014-10-02

    申请号：PCT/IB2014/059381

    申请日：2014-03-03

    Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED

    Inventor： ERNST, Burkhard ,  EHRESMANN, Manfred ,  KORADIN, Christopher ,  PLETSCH, Andreas ,  BONNEKESSEL, Melanie ,  KAEDING, Thomas ,  SCHEIN-ALBRECHT, Karin ,  DEMMING, Stefanie ,  WEBER, Franz ,  SIEGEL, Wolfgang ,  SCHRöDER, Hartwig ,  FREYER, Stephan ,  ÖDMAN, Peter

    IPC: C12P17/18

    CPC classification number: C07D493/04 ,  A01N43/40 ,  C12P17/181

    Abstract: The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.

    Abstract translation: 本发明涉及产生拟南芥生产生物体的干生物质的方法，从这种干生物质获得拟南芥的方法，以及产生式（Ⅲ）和/或式（Ⅳ）和/或式（Ⅴ）化合物的方法， 来自干生物质获得的吡柔比星。 本发明进一步涉及干生物质本身，以及使用所述干生物质获得用于生产式（III）和/或式（IV）和/或式（V）的化合物的吡啶并苯的方法，包括使用 所述干燥生物质以获得拟南芥或式III化合物和/或式（Ⅳ）和/或式（Ⅴ）化合物，以便制备包含这些化合物的害虫控制组合物，特别是杀虫剂。

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