公开(公告)号：JP2014114322A

公开(公告)日：2014-06-26

申请号：JP2014031168

申请日：2014-02-21

Applicant: Basf Se ,  ビーエーエスエフ ソシエタス・ヨーロピアBasf Se

Inventor： KOLTER KARL ,  MICHAEL SCHOENHERR ,  SILKE GEBERT ,  KATHRIN MEYER-BOHM ,  ANGELIKA MASCHKE

IPC: A61K9/26 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K9/2018 ,  A61K9/0056 ,  A61K9/2027 ,  A61K9/2054

Abstract: PROBLEM TO BE SOLVED: To provide tablets which disintegrate rapidly in the mouth, leave behind a pleasant sensation in the mouth, are mechanically very stable, and provide high content uniformity.SOLUTION: A pharmaceutical formulation in the form of agglomerates comprises the following components A) and B): A) an excipient consisting of a) 60-97% by weight of sugar or sugar alcohols, b) 1-25% by weight of a disintegration agent, c) 1-15% by weight of water-insoluble, film-forming polymers, d) 0-15% by weight of water-soluble polymers, and e) 0-15% by weight of another pharmaceutically customary excipients, wherein the sum of the components a) to e) is 100% by weight; and B) at least one active ingredient.

Abstract translation: 要解决的问题：提供在口中快速崩解的片剂，在口中留下愉快的感觉，机械上非常稳定，并提供高含量均匀性。溶解剂：附聚物形式的药物制剂包含以下组分A ）和B）：A）由a）60-97重量％的糖或糖醇组成的赋形剂，b）1-25重量％的崩解剂，c）1-15重量％的水不溶性 ，成膜聚合物，d）0-15重量％的水溶性聚合物，和e）0-15重量％的另一种药学上常规的赋形剂，其中组分a）至e）的总和为100％ 重量; 和B）至少一种活性成分。

公开(公告)号：AU2006301307B2

公开(公告)日：2012-01-12

申请号：AU2006301307

申请日：2006-10-05

Applicant: BASF SE

Inventor： KATHRIN MEYER-BOHM ,  KARL KOLTER ,  ANISUL QUADIR

IPC: C07C57/30 ,  A61K9/16 ,  A61K9/20

Abstract: Disclosed is a directly compressible ibuprofen formulation containing a) 50 to 99 percent by weight of crystalline ibuprofen, b) 1 to 15 percent by weight of a highly dispersible adjuvant having a minimum surface of 100 m/g, and c) 0 to 40 percent by weight of other adjuvants provided that the total quantity of components a) to c) amounts to 100 percent by weight, at least 50 percent of the surface of the ibuprofen crystals being coated with the highly dispersible adjuvant.