公开(公告)号：AU2006301307A1

公开(公告)日：2007-04-19

申请号：AU2006301307

申请日：2006-10-05

Applicant: BASF SE

Inventor： MEYER-BOHM KATHRIN ,  KOLTER KARL ,  QUADIR ANISUL

IPC: A61K9/16 ,  A61K9/20 ,  C07C57/30

Abstract: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.

公开(公告)号：AU2006301307C1

公开(公告)日：2012-05-24

申请号：AU2006301307

申请日：2006-10-05

Applicant: BASF SE

Inventor： MEYER-BOHM KATHRIN ,  KOLTER KARL ,  QUADIR ANISUL

IPC: C07C57/30 ,  A61K9/16 ,  A61K9/20

Abstract: Disclosed is a directly compressible ibuprofen formulation containing a) 50 to 99 percent by weight of crystalline ibuprofen, b) 1 to 15 percent by weight of a highly dispersible adjuvant having a minimum surface of 100 m/g, and c) 0 to 40 percent by weight of other adjuvants provided that the total quantity of components a) to c) amounts to 100 percent by weight, at least 50 percent of the surface of the ibuprofen crystals being coated with the highly dispersible adjuvant.

公开(公告)号：DE602005022396D1

公开(公告)日：2010-09-02

申请号：DE602005022396

申请日：2005-11-05

Applicant: BASF CORP ,  BASF SE

Inventor： LISA RUDOLPH ERNEST ,  QUADIR ANISUL ,  HAM SCHEPER REBECCA ,  GRZESIOWSKI PETER

IPC: A61K9/14

公开(公告)号：BRPI0617180A2

公开(公告)日：2013-02-26

申请号：BRPI0617180

申请日：2006-10-05

Applicant: BASF SE

Inventor： KOLTER KARL ,  QUADIR ANISUL ,  MEYER-BOEHM KATHRIN

IPC: A61K9/16 ,  A61K9/20 ,  C07C57/30

Abstract: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.

公开(公告)号：AT474557T

公开(公告)日：2010-08-15

申请号：AT05024161

申请日：2005-11-05

Applicant: BASF SE

Inventor： LISA RUDOLPH ERNEST ,  QUADIR ANISUL ,  HAM SCHEPER REBECCA ,  GRZESIOWSKI PETER

IPC: A61K9/14

Abstract: A method for formation of micro-prilled poloxamer particles is disclosed. The particles find special use in pharmaceutical formulations. The process involves use of atomizing nozzles at higher than normal pressure atomizing gas, high atomizing gas temperature, use of high feed temperatures to reduce the viscosity of the poloxamer and optionally sieving after prill formation in prilling towers. The poloxamer particles are spherical and preferably have an average nominal diameter of less than or equal to 106 microns. The process is very cost effective and rapid.