公开(公告)号：CA2113550A1

公开(公告)日：1993-12-09

申请号：CA2113550

申请日：1993-05-24

Applicant: BAXTER DIAGNOSTICS INC

Inventor： LEVINSON MITCHELL E ,  BROWN GARY P ,  LICHTENSTEIN DONALD ,  MORRIS ROGER J

IPC: B01L99/00 ,  B01L7/02 ,  C12M1/00 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04 ,  C12M3/00 ,  G01N21/84

Abstract: 2113550 9324234 PCTABS00028 An instrument for culturing and detecting the presence of microorganisms in human tissue specimens is disclosed. The instrument includes one or more drawers slidably received within the instrument housing. The drawers include racks for holding and agitating a plurality of specimen containing bottles. The instrument may include a mechanical drive apparatus designed to move the racks in a substantially sinusoidal pattern of motion. The racks are preferably provided with gripping means for removably and repeatably positioning the bottles within the drawer. An optical detection system is also disclosed, in which an optical filter is used to render a photodetector substantially blind to all light other than light emitted by a fluorescent sensor located within the specimen vessel, including excitation light impinging on the sensor. The instrument preferably includes a forced air convection system for warming the interior of the drawers and the specimen vessels held therein.

公开(公告)号：CA2077560A1

公开(公告)日：1992-07-05

申请号：CA2077560

申请日：1991-12-23

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  BOBOLIS JAMIE ,  SHERMAN DAVID ,  OLSON CAROLYN

IPC: C12M1/34 ,  C12Q1/06 ,  G01N20060101 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N21/80 ,  G01N33/49 ,  G01N33/52

Abstract: 2077560 9212413 PCTABS00014 The present invention is a multi-layer blood culture sensor which includes a pH sensitive absorbance dye encapsulated in or isolated by a first light transmissive gas permeable, proton impermeable matrix (2) and a pH insensitive fluorescence dye in a second matrix (4), the first and second matrices being spectrally coupled, and a method to use this sensor to detect microorganisms in a blood culture bottle.

公开(公告)号：WO9324234A3

公开(公告)日：1994-03-31

申请号：PCT/US9305233

申请日：1993-05-24

Applicant: BAXTER DIAGNOSTICS INC

Inventor： LEVINSON MITCHELL E ,  BROWN GARY P ,  LICHTENSTEIN DONALD ,  MORRIS ROGER J

IPC: B01L99/00 ,  B01L7/02 ,  C12M1/00 ,  C12M1/34 ,  G01N35/00 ,  G01N35/04

CPC classification number: C12M41/14 ,  B01L7/02 ,  C12M23/48 ,  C12M41/48 ,  G01N21/783 ,  G01N21/80 ,  G01N35/00 ,  G01N2021/7786 ,  G01N2035/0498

Abstract: An instrument for culturing and detecting the presence of microorganisms in human tissue specimens is disclosed. The instrument includes one or more drawers slidably received within the instrument housing. The drawers include racks for holding and agitating a plurality of specimen containing bottles. The instrument may include a mechanical drive apparatus designed to move the racks in a substantially sinusoidal pattern of motion. The racks are preferably provided with gripping means for removably and repeatably positioning the bottles within the drawer. An optical detection system is also disclosed, in which an optical filter is used to render a photodetector substantially blind to all light other than light emitted by a fluorescent sensor located within the specimen vessel, including excitation light impinging on the sensor. The instrument preferably includes a forced air convection system for warming the interior of the drawers and the specimen vessels held therein.

公开(公告)号：CA2086608A1

公开(公告)日：1992-11-09

申请号：CA2086608

申请日：1992-04-29

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  GREEN CALVERT L

IPC: A61J1/14 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/06 ,  G01N21/78 ,  G01N21/80 ,  A61J1/18 ,  A61K35/14

Abstract: 2086608 9219764 PCTABS00017 The present invention relates to a growth monitoring apparatus for collected transfusable bodily fluids. In particular the apparatus involves a flexible blood collection bag (20) or a sample bag (20) containing microbial growth media. A sensor (22) attached to the inside wall of the bag (20) is used to noninvasively detect microbial contamination within the bag (20). This invention also relates to a method to detect microbial growth in a blood collection bag (20) immediately prior to transfusion.

公开(公告)号：MX9101919A

公开(公告)日：1992-07-08

申请号：MX9101919

申请日：1991-11-05

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  OLSON CAROLYN SHELSHUK

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78 ,  G01J3/46

Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.

公开(公告)号：CA2070806A1

公开(公告)日：1992-05-06

申请号：CA2070806

申请日：1991-10-30

Applicant: BAXTER DIAGNOSTICS INC

Inventor： MORRIS ROGER J ,  BASCOMB SHOSHANA ,  OLSON CAROLYN S

IPC: C12Q1/26 ,  G01N21/17 ,  G01N21/53 ,  G01N21/78 ,  G01N21/84

Abstract: 2070806 9208123 PCTABS00013 The present invention relates to a process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluoroscence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.