公开(公告)号：WO02101269A3

公开(公告)日：2003-03-20

申请号：PCT/US0218633

申请日：2002-06-12

Applicant: BAXTER INT

Inventor： WILLIAMSON MARK E ,  ARIAGNO SCOTT R ,  MARTTILA ALAN W ,  BILSTAD ARNOLD C ,  DIPERNA PAUL M ,  PRISCO MICHAEL R ,  PENNINGTON DAVID W ,  YARDIMCI ATIF M ,  SMITH SIDNEY T ,  PERRY MARK C ,  BELLOTTI MARC

IPC: F16K7/12 ,  A47G21/18 ,  A61J1/05 ,  A61J1/10 ,  A61J15/00 ,  A61M11/06 ,  A61M15/00 ,  A61M39/00 ,  A61M39/22 ,  F16K7/17 ,  F16K15/02 ,  F16K15/03 ,  F16K15/14 ,  A61M39/24 ,  B65D47/20

CPC classification number: A61J7/0053 ,  A47G21/185 ,  A61J1/10 ,  A61J1/1475 ,  A61J7/0046 ,  A61M39/227 ,  A61M39/24 ,  A61M2039/2406 ,  A61M2039/242 ,  A61M2039/244 ,  A61M2039/2486 ,  F16K15/14 ,  F16K15/147 ,  Y10S137/907 ,  Y10T137/7781 ,  Y10T137/7836 ,  Y10T137/7882 ,  Y10T137/789

Abstract: A vacuum demand valve (10) is capable of delivering a flowable material. The valve (10) has a housing (11) having a proximal end (14), a distal end (16), an intermediate segment (18) therebetween defining a passageway (24) wherein the flowable substance can flow from the proximal end (14) to the distal end (16). The housing (11) can be tubing. A valve member (20) is located along the intermediate segment (18). The valve member (20) has a closed condition wherein the flowable material from the proximal end (14) to the distal end (16) is stopped and an open condition wherein the flow of the flowable material from the proximal end (14) to the distal end (16) is unstopped. The valve member (20) is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway (24) for placing the valve member (20) in the open condition.

Abstract translation: 真空需求阀（10）能够输送可流动的材料。 阀（10）具有壳体（11），其具有近端（14），远端（16），间隔开的中间段（18），限定通道（24），其中可流动物质可以从近端（ 14）到远端（16）。 外壳（11）可以是管道。 阀构件（20）沿着中间段（18）定位。 阀构件（20）具有闭合状态，其中从近端（14）到远端（16）的可流动材料停止，并且打开状态，其中可流动材料从近端（14）流到 远端（16）不受阻挡。 阀构件（20）在关闭状态下被偏压并且响应于用户通过通道（24）提供的用于将阀构件（20）置于打开状态的部分真空。

公开(公告)号：WO2004108060A8

公开(公告)日：2005-03-10

申请号：PCT/US2004015509

申请日：2004-05-20

Applicant: BAXTER INT ,  NEWBROUGH JERRY W ,  SLEPICKA JAMES S ,  BILSTAD ARNOLD C ,  DEFOGGI JOHN MARK ,  BOSCHELLI MARIANNE M ,  JANDRISITS ALICE M ,  WU BIHONG

Inventor： NEWBROUGH JERRY W ,  SLEPICKA JAMES S ,  BILSTAD ARNOLD C ,  DEFOGGI JOHN MARK ,  BOSCHELLI MARIANNE M ,  JANDRISITS ALICE M ,  WU BIHONG

IPC: A61J1/00 ,  A61J1/20

CPC classification number: A61J1/2089 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2058 ,  A61J1/2075 ,  A61J1/2082 ,  Y10T137/8122 ,  Y10T137/8342 ,  Y10T137/8622

Abstract: A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannula having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port formed thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communication with the vent port through a vent lumen.

Abstract translation: 公开了重构装置，并且包括第一容器接收器，其具有设置在其中的第一部件插管，第一部件插管具有取出口和形成在其上的第一传送端口，第二容器接收器具有设置在其上的第二部件插管，第二部件 插管，其具有形成在其上的通气口和第二传送端口，将第一容器接收器连接到第二容器接收器并且具有形成在其中的传送腔的设备本体，与第一和第二传送端口流体连通的传送腔， 密封界面固定到装置主体并与抽出口流体连通;以及排气构件，其通过通气腔与通气口连通。

公开(公告)号：WO0062820A3

公开(公告)日：2001-03-08

申请号：PCT/US0009751

申请日：2000-04-12

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  MARTTILA ALAN W ,  WOODWORTH ARCHIE

IPC: A61L2/24 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/14 ,  A61L2/20 ,  A61M39/18 ,  B29C65/00 ,  B29C65/02 ,  B29C65/04 ,  B29C65/10 ,  B29C65/48 ,  B67C7/00 ,  B65B55/02

CPC classification number: A61L2/00 ,  A61L2/08 ,  A61L2/087 ,  A61L2/14 ,  A61L2/208 ,  A61L2202/23 ,  A61L2202/24 ,  A61M39/18 ,  B29C65/02 ,  B29C65/04 ,  B29C65/103 ,  B29C65/4895 ,  B29C66/0018 ,  B29C66/1142 ,  B29C66/5221 ,  B29C66/5229 ,  B29C66/52293 ,  B29C66/52298 ,  B29C66/73921 ,  B29C66/81431 ,  B29C66/83221 ,  B29C66/857 ,  B29L2023/007 ,  B67C7/0073

Abstract: The connection, assembly, or fill of two or more pre-sterilized components having at least one terminal end each for attachment to another component, and an apparatus for performing such a connection, while maintaining the sterility of the components is disclosed. The resulting connection is made permanent by bonding the contacting components together using either a solvent bonding technique, a radio frequency sealer, a heat sealer, or any other suitable process. The connection is preferably made within an active sterile field. Using a low-voltage electron beam instrument, such as the MIN-EB , a suitable sterile field sphere can be created. The terminal ends of the multiple components remain withing the sterile field sphere until the possibility of contamination within the sealed components is significantly reduced to industry acceptable standards.

Abstract translation: 公开了两个或更多个预灭菌组件的连接，组装或填充，其具有至少一个终端，用于附接到另一组件，以及用于执行这种连接的设备，同时保持组件的无菌性。 通过使用溶剂粘合技术，无线电频率封隔器，热封机或任何其它合适的工艺将接触部件粘合在一起，使得到的连接永久化。 连接优选在活性无菌区域内进行。 使用诸如MIN-EB TM的低电压电子束仪器可以产生合适的无菌场球。 多个部件的末端保留无菌场球，直到密封部件内污染的可能性显着降低到工业上可接受的标准。

公开(公告)号：DE60043813D1

公开(公告)日：2010-03-25

申请号：DE60043813

申请日：2000-04-12

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  MARTTILA ALAN W ,  WOODWORTH ARCHIE

IPC: A61L2/00 ,  A61L2/24 ,  A61L2/08 ,  A61L2/10 ,  A61L2/14 ,  A61L2/20 ,  A61M39/18 ,  B29C65/00 ,  B29C65/02 ,  B29C65/04 ,  B29C65/10 ,  B29C65/48 ,  B67C7/00

Abstract: The connection, assembly, or fill of two or more pre-sterilized components having at least one terminal end each for attachment to another component, and an apparatus for performing such a connection, while maintaining the sterility of the components is disclosed. The resulting connection is made permanent by bonding the contacting components together using either a solvent bonding technique, a radio frequency sealer, a heat sealer, or any other suitable process. The connection is preferably made within an active sterile field. Using a low-voltage electron beam instrument, such as the MIN-EB(TM), a suitable sterile field sphere can be created. The terminal ends of the multiple components remain within the sterile field sphere until the possibility of contamination within the sealed components is significantly reduced to industry acceptable standards.

公开(公告)号：AT457184T

公开(公告)日：2010-02-15

申请号：AT00925941

申请日：2000-04-12

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  MARTTILA ALAN W ,  WOODWORTH ARCHIE

IPC: A61L2/24 ,  A61M39/18 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/14 ,  A61L2/20 ,  B29C65/00 ,  B29C65/02 ,  B29C65/04 ,  B29C65/10 ,  B29C65/48 ,  B67C7/00

Abstract: The connection, assembly, or fill of two or more pre-sterilized components having at least one terminal end each for attachment to another component, and an apparatus for performing such a connection, while maintaining the sterility of the components is disclosed. The resulting connection is made permanent by bonding the contacting components together using either a solvent bonding technique, a radio frequency sealer, a heat sealer, or any other suitable process. The connection is preferably made within an active sterile field. Using a low-voltage electron beam instrument, such as the MIN-EB(TM), a suitable sterile field sphere can be created. The terminal ends of the multiple components remain within the sterile field sphere until the possibility of contamination within the sealed components is significantly reduced to industry acceptable standards.

公开(公告)号：CA2527922A1

公开(公告)日：2004-12-16

申请号：CA2527922

申请日：2004-05-20

Applicant: BAXTER INT

Inventor： BOSCHELLI MARIANNE M ,  JANDRISITS ALICE M ,  WU BIHONG ,  NEWBROUGH JERRY W ,  BILSTAD ARNOLD C ,  DEFOGGI JOHN MARK ,  SLEPICKA JAMES S

IPC: A61J1/20 ,  A61J1/00

Abstract: A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannu la having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port forme d thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communicatio n with the vent port through a vent lumen.

公开(公告)号：CA2450461A1

公开(公告)日：2002-12-19

申请号：CA2450461

申请日：2002-06-12

Applicant: BAXTER INT

Inventor： MARTTILA ALAN W ,  BILSTAD ARNOLD C ,  DIPERNA PAUL M ,  PRISCO MICHAEL R ,  YARDIMCI ATIF M ,  PENNINGTON DAVID W ,  SMITH SIDNEY T ,  BELLOTTI MARC ,  ARIAGNO SCOTT R ,  WILLIAMSON MARK E ,  PERRY MARK C

IPC: F16K7/12 ,  A47G21/18 ,  A61J1/05 ,  A61J1/10 ,  A61J15/00 ,  A61M11/06 ,  A61M15/00 ,  A61M39/00 ,  A61M39/22 ,  F16K7/17 ,  F16K15/02 ,  F16K15/03 ,  F16K15/14 ,  B65D47/20 ,  A61M39/24

Abstract: A vacuum demand valve (10) is capable of delivering a flowable material. The valve (10) has a housing (11) having a proximal end (14), a distal end (16), an intermediate segment (18) therebetween defining a passageway (24) wherein the flowable substance can flow from the proximal end (14) to the distal end (16). The housing (11) can be tubing. A valve member (20) is located along t he intermediate segment (18). The valve member (20) has a closed condition wherein the flowable material from the proximal end (14) to the distal end (16) is stopped and an open condition wherein the flow of the flowable material from the proximal end (14) to the distal end (16) is unstopped. The valve member (20) is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway (24) for placing the valve member (20) in the open condition.

公开(公告)号：ES2097381T3

公开(公告)日：1997-04-01

申请号：ES93103620

申请日：1993-03-06

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  LEWIS ROBERT E ,  LILLEGARD THOMAS R ,  OILSCHLAGER EDWARD G ,  SCHUMACHER WILLIAM L ,  SMITH SIDNEY T

IPC: A61J3/00 ,  A61M39/00 ,  B01F13/10

Abstract: The present invention provides an improved transfer set for use in an automated compounding device. The transfer set comprises a plurality of fluid conduits, each fluid conduit including a first section and a second section, the first and second sections being coupled together in fluid communication by a coupler. A housing is provided for receiving at least a portion of the fluid conduits and the coupler. The housing defines separate channels for receiving a portion of the second section of each fluid conduit. The channels extend for a sufficient distance so that at least substantially an entire length of the second section that is located in the housing is located in a channel thereby securing the fluid conduits in place in the housing. An improved method for making a transfer set is also provided.

公开(公告)号：CA2649673C

公开(公告)日：2010-06-15

申请号：CA2649673

申请日：2000-04-12

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  MARTTILA ALAN W ,  WOODWORTH ARCHIE

IPC: A61L2/24 ,  B65B55/02 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/14 ,  A61L2/20 ,  A61M39/18 ,  B29C65/00 ,  B29C65/02 ,  B29C65/04 ,  B29C65/10 ,  B29C65/48 ,  B67C7/00 ,  B67D99/00

Abstract: A method for sterile filling a pre-sterilized container having a filling port with a bulk sterile fluid comprises the steps of, establishing an active sterile field, introducing the filling port of the pre-sterilized container into the active sterile field, transferring an aliquot of the bulk sterile fluid from a supply container to the pre-sterilized container through the filling port while in the active sterile field and removing the filling port of the pre-sterilized container from the active sterile field.

公开(公告)号：CA2365557C

公开(公告)日：2010-03-30

申请号：CA2365557

申请日：2000-04-12

Applicant: BAXTER INT

Inventor： BILSTAD ARNOLD C ,  BUCHANAN BRADLEY H ,  MARTTILA ALAN W ,  WOODWORTH ARCHIE

IPC: A61L2/24 ,  A61M39/18 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/14 ,  A61L2/20 ,  B29C65/00 ,  B29C65/02 ,  B29C65/04 ,  B29C65/10 ,  B29C65/48 ,  B65B55/02 ,  B67C7/00

Abstract: The connection, assembly, or fill of two or more pre-sterilized components having at least one terminal end each for attachment to another component, and an apparatus for performing such a connection, while maintaining the sterility of the components is disclosed. The resulting connection is made permanent by bonding the contacting components together using either a solvent bonding technique, a radio frequency sealer, a heat sealer, or any other suitable process. The connection is preferably made within an active sterile field. Using a low-voltage electron beam instrument, such as the MIN-EB.TM., a suitable sterile field sphere can be created. The terminal ends of the multiple components remain withing the sterile field sphere until the possibility of contamination within the sealed components is significantly reduced to industry acceptable standards.