公开(公告)号：WO2007032993A3

公开(公告)日：2007-05-10

申请号：PCT/US2006034891

申请日：2006-09-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  CHAUBAL MAHESH ,  DOTY MARK J ,  KONKEL JAMIE T ,  RABINOW BARRETT E

Inventor： CHAUBAL MAHESH ,  DOTY MARK J ,  KONKEL JAMIE T ,  RABINOW BARRETT E

IPC: A61K9/10 ,  A61K9/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K47/24 ,  A61K47/34 ,  B01J13/00

CPC classification number: B01J13/04 ,  A61K9/10 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/146 ,  A61K31/436

Abstract: Submicron particles of an organic compound, such as therapeutic and diagnostic agent are disclosed. The organic compound particles are associated with a least two surfactants including a block copolymer and phospholipids conjugated with a hydrophilic polymer.

Abstract translation: 公开了有机化合物的亚微米颗粒，例如治疗剂和诊断剂。 有机化合物颗粒与至少两种表面活性剂结合，包括嵌段共聚物和与亲水聚合物共轭的磷脂。

公开(公告)号：WO2005044225A3

公开(公告)日：2005-12-01

申请号：PCT/US2004035335

申请日：2004-10-25

Applicant: BAXTER INT ,  CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

Inventor： CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1688 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultantously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

Abstract translation: 本发明涉及通过将溶解在水混溶性有机溶剂中的有机化合物的溶液与水性介质混合形成混合物并同时均化混合物同时连续除去有机溶剂而形成有机化合物的小颗粒 以形成基本上不含有机溶剂的小颗粒的水性悬浮液。 这些方法优选用于制备适用于通过行政途径（例如肠胃外，口腔，鼻，口腔，局部，眼科，直肠，阴道）的体内递送的难溶于水的药物活性化合物的小颗粒的水悬浮液 ，透皮等。

公开(公告)号：DK1682116T3

公开(公告)日：2012-09-03

申请号：DK04810266

申请日：2004-11-03

Applicant: BAXTER INT

Inventor： CHAUBAL MAHESH ,  WERLING JANE ,  RABINOW BARRETT E

IPC: A61K31/337 ,  A61K9/10 ,  A61K9/127 ,  A61K9/133 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

公开(公告)号：AU2004287427A1

公开(公告)日：2005-05-19

申请号：AU2004287427

申请日：2004-10-25

Applicant: BAXTER INT

Inventor： DOTY MARK ,  GELMAN YEFIM ,  CHAUBAL MAHESH ,  WISLER MONTE

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：BRPI0416007A

公开(公告)日：2007-01-02

申请号：BRPI0416007

申请日：2004-10-25

Applicant: BAXTER INT

Inventor： CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：NO20062552L

公开(公告)日：2006-06-02

申请号：NO20062552

申请日：2006-06-02

Applicant: BAXTER INT

Inventor： WERLING JANE ,  RABINOW BARRETT E ,  CHAUBAL MAHESH

IPC: A61K9/14 ,  A61K9/10 ,  A61K9/127 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.

公开(公告)号：FR2959133A1

公开(公告)日：2011-10-28

申请号：FR1053063

申请日：2010-04-22

Applicant: SANOFI AVENTIS ,  BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： CHAUBAL MAHESH

IPC: A61K31/437 ,  A61P35/00

Abstract: La présente invention concerne des particules submicroniques de 3-(2,4-dichloro-phényl)-1,6-diméthyl-1,9-dihydro-pyrido[2,3-b]indol-2-one , des compositions de celles-ci, des procédés pour préparer et utiliser celles-ci.

公开(公告)号：CA2621492A1

公开(公告)日：2007-03-22

申请号：CA2621492

申请日：2006-09-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： CHAUBAL MAHESH ,  DOTY MARK J ,  KONKEL JAMIE T ,  RABINOW BARRETT E

IPC: A61K9/10 ,  A61K9/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K47/24 ,  A61K47/34 ,  B01J13/00

公开(公告)号：NO20062378A

公开(公告)日：2006-05-24

申请号：NO20062378

申请日：2006-05-24

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  WISLER MONTE ,  CHAUBAL MAHESH ,  GEIMAN YEFIM

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1688 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

公开(公告)号：AU2004289233A1

公开(公告)日：2005-05-26

申请号：AU2004289233

申请日：2004-11-03

Applicant: BAXTER INT

Inventor： CHAUBAL MAHESH ,  RABINOW BARRETT E ,  WERLING JANE

IPC: A61K31/337 ,  A61K9/10 ,  A61K9/127 ,  A61K9/133 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.