公开(公告)号：WO2005044225A3

公开(公告)日：2005-12-01

申请号：PCT/US2004035335

申请日：2004-10-25

Applicant: BAXTER INT ,  CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

Inventor： CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1688 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultantously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

Abstract translation: 本发明涉及通过将溶解在水混溶性有机溶剂中的有机化合物的溶液与水性介质混合形成混合物并同时均化混合物同时连续除去有机溶剂而形成有机化合物的小颗粒 以形成基本上不含有机溶剂的小颗粒的水性悬浮液。 这些方法优选用于制备适用于通过行政途径（例如肠胃外，口腔，鼻，口腔，局部，眼科，直肠，阴道）的体内递送的难溶于水的药物活性化合物的小颗粒的水悬浮液 ，透皮等。

公开(公告)号：WO2004084860A3

公开(公告)日：2005-03-24

申请号：PCT/US2004009242

申请日：2004-03-24

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WISLER MONTE ,  GARCIA RHONDA

IPC: A61K9/10 ,  A61K9/14

CPC classification number: A61K9/145 ,  A61K9/10 ,  Y10S516/924 ,  Y10S516/925 ,  Y10S977/84

Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.

Abstract translation: 提供粉碎和稳定小颗粒的方法和装置。 在一个实施方案中，装置移动溶解在溶剂中的有机化合物以形成第一流体物流中的颗粒悬浮液并将悬浮液移动到第二流体流中，其中第二流体流相对于第一流定向和定位 以引起流之间的剪切和第一和第二流中的至少一些颗粒的混合。

公开(公告)号：BRPI0416007A

公开(公告)日：2007-01-02

申请号：BRPI0416007

申请日：2004-10-25

Applicant: BAXTER INT

Inventor： CHAUBAL MAHESH ,  DOTY MARK ,  GELMAN YEFIM ,  WISLER MONTE

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：CA2541493A1

公开(公告)日：2005-05-19

申请号：CA2541493

申请日：2004-10-25

Applicant: BAXTER INT

Inventor： GELMAN YEFIM ,  WISLER MONTE ,  DOTY MARK ,  CHAUBAL MAHESH

IPC: A61K9/16 ,  A61K9/10 ,  A61K9/14 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：AU2004224307A1

公开(公告)日：2004-10-07

申请号：AU2004224307

申请日：2004-03-24

Applicant: BAXTER INT

Inventor： WISLER MONTE ,  KIPP JAMES E ,  GARCIA RHONDA ,  WONG JOSEPH CHUNG TAK

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/00

Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.

公开(公告)号：NO20054908A

公开(公告)日：2005-12-21

申请号：NO20054908

申请日：2005-10-24

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WISLER MONTE ,  GARCIA RHONDA

IPC: A61K9/10 ,  A61K9/14

CPC classification number: A61K9/145 ,  A61K9/10 ,  Y10S516/924 ,  Y10S516/925 ,  Y10S977/84

公开(公告)号：AU2004287427A1

公开(公告)日：2005-05-19

申请号：AU2004287427

申请日：2004-10-25

Applicant: BAXTER INT

Inventor： DOTY MARK ,  GELMAN YEFIM ,  CHAUBAL MAHESH ,  WISLER MONTE

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：NO20062378L

公开(公告)日：2006-05-24

申请号：NO20062378

申请日：2006-05-24

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  WISLER MONTE ,  CHAUBAL MAHESH ,  GEIMAN YEFIM

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.

公开(公告)号：BRPI0408707A

公开(公告)日：2006-03-07

申请号：BRPI0408707

申请日：2004-03-24

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WISLER MONTE ,  GARCIA RHONDA

IPC: A61K9/10 ,  A61K9/14

Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.

公开(公告)号：CA2519536A1

公开(公告)日：2004-10-07

申请号：CA2519536

申请日：2004-03-24

Applicant: BAXTER INT

Inventor： WONG JOSEPH CHUNG TAK ,  WISLER MONTE ,  KIPP JAMES E ,  GARCIA RHONDA

IPC: A61K9/10 ,  A61K9/14

Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolve d in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stre am is oriented and positioned with respect to the first stream to cause shearin g between the streams and mixing of at least some of the particles in the firs t and second streams.