公开(公告)号：NO20062378A

公开(公告)日：2006-05-24

申请号：NO20062378

申请日：2006-05-24

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  WISLER MONTE ,  CHAUBAL MAHESH ,  GEIMAN YEFIM

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

CPC classification number: A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1688 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

公开(公告)号：NO20062378L

公开(公告)日：2006-05-24

申请号：NO20062378

申请日：2006-05-24

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  WISLER MONTE ,  CHAUBAL MAHESH ,  GEIMAN YEFIM

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.