公开(公告)号：EP1058563A4

公开(公告)日：2002-03-20

申请号：EP98957791

申请日：1998-11-11

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LIKENS MATTHEW E ,  GOLDHABER RICHARD P ,  DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61K35/14 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D17/02 ,  B01D21/00 ,  B01D21/24 ,  B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/08 ,  B01D61/22

CPC classification number: B01D21/2405 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3496 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/082 ,  B01D17/0217 ,  B01D17/085 ,  B01D21/0012 ,  B01D21/26 ,  B01D2221/10

Abstract: Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

公开(公告)号：AT248011T

公开(公告)日：2003-09-15

申请号：AT96916645

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D21/26 ,  B01D33/00 ,  B01D33/06 ,  B01D61/00

Abstract: The method comprises adding to the whole blood, prior to separation, an anticoagulant solution comprising citric acid, trisodium citrate and dextrose and no phosphate, and storing the separated red blood cells in a storage solution comprising dextrose, adenine, mannitol and sodium chloride.

公开(公告)号：CA2074815A1

公开(公告)日：1992-06-12

申请号：CA2074815

申请日：1991-12-06

Applicant: BAXTER INT

Inventor： DUFF DANIEL H

IPC: A61M1/02 ,  A61M1/26 ,  A61M1/34 ,  A61M1/36 ,  B01D61/14 ,  B01D61/22 ,  A61M1/16

Abstract: A processing system (30) separates a cellular rich suspen- sion (32) into a cellular first constituent (36) and cellular-free sec- ond constituent (38). The system (30) includes a separation zone (40) that receives the cellular rich suspension (32) and discharges the first (36) and second constituents (38). The system (30) coord- inates the flow of cellular rich suspension (32) into the separation zone (40) with the flow of cellular-free second constituent (38) from the separation zone (40) to get a desired nominal separation efficiency. The system (30) also recirculates the cellular first con- stituent (36) back into the zone (40). By continuously recirculat- ing the cellular first constituent (36) back into the separation zone (40), the system (30) can get and maintain a desired volume of the first constituent (36), despite the volume of cellular rich suspen- sion (32) that is processed. By continuously recirculating the cel- lular first constituent (36) back into the separation zone (40), the system (30) also can provide operating conditions within the se- paration zone (40) that maximize separation efficiencies but that, without the benefits of recirculation, could otherwise damage or traumatize the cellular first constituent (36).

公开(公告)号：CA2198696C

公开(公告)日：2006-05-16

申请号：CA2198696

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： DUFF DANIEL H ,  DENIEGA JOSE C

IPC: A61K35/14 ,  A61M1/34 ,  A01N1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16

Abstract: Blood separation systems and methods utilize a membrane separation device (5 2) comprising a gap (60) between a microporous membrane (64) and a surface (56) facing the microporous membrane (64), one of the microporous membrane (64) a nd the surface (56) being rotatable relative to the other to cause separation o f whole blood in the gap (60) into plasma and concentrated red blood cells. The systems and methods include an inlet pump element (20) and a drive element (46) coupled to the membrane separation device (52) and the steps of commanding the inlet pump element (20) and the drive element (46) as a function of the known beginning hematocrit value to obtain concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in th e known beginning hematocrit value.

公开(公告)号：CA2074815C

公开(公告)日：2001-10-16

申请号：CA2074815

申请日：1991-12-06

Applicant: BAXTER INT

Inventor： DUFF DANIEL H

IPC: A61M1/02 ,  A61M1/26 ,  A61M1/34 ,  A61M1/36 ,  B01D61/14 ,  B01D61/22 ,  A61M1/16

Abstract: A processing system (30) separates a cellular rich suspen- sion (32) into a cellular first constituent (36) and cellular-free sec- ond constituent (38). The system (30) includes a separation zone (40) that receives the cellular rich suspension (32) and discharges the first (36) and second constituents (38). The system (30) coord- inates the flow of cellular rich suspension (32) into the separation zone (40) with the flow of cellular-free second constituent (38) from the separation zone (40) to get a desired nominal separation efficiency. The system (30) also recirculates the cellular first con- stituent (36) back into the zone (40). By continuously recirculat- ing the cellular first constituent (36) back into the separation zone (40), the system (30) can get and maintain a desired volume of the first constituent (36), despite the volume of cellular rich suspen- sion (32) that is processed. By continuously recirculating the cel- lular first constituent (36) back into the separation zone (40), the system (30) also can provide operating conditions within the se- paration zone (40) that maximize separation efficiencies but that, without the benefits of recirculation, could otherwise damage or traumatize the cellular first constituent (36).

公开(公告)号：AU5932896A

公开(公告)日：1997-03-05

申请号：AU5932896

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D21/26 ,  B01D33/00 ,  B01D33/06 ,  B01D61/00 ,  B01D61/22 ,  A61M1/00

Abstract: The method comprises adding to the whole blood, prior to separation, an anticoagulant solution comprising citric acid, trisodium citrate and dextrose and no phosphate, and storing the separated red blood cells in a storage solution comprising dextrose, adenine, mannitol and sodium chloride.

公开(公告)号：CA2198696A1

公开(公告)日：1997-02-20

申请号：CA2198696

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61K35/14 ,  A01N1/02

Abstract: Blood separation systems and methods utilize a membrane separation device (52) comprising a gap (60) between a microporous membrane (64) and a surface (56) facing the microporous membrane (64), one of the microporous membranes (64) and the surface (56) being rotatable relative to the other to cause separation of whole blood in the gap (60) into plasma and concentrated red blood cells. The systems and methods include an inlet pump element (20) and a drive element (46) coupled to the membrane separation device (52) and the steps of commanding the inlet pump element (20) and the drive element (46) as a function of the known beginning hematocrit value to obtain concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in the known beginning hematocrit value.