公开(公告)号：EP1058563A4

公开(公告)日：2002-03-20

申请号：EP98957791

申请日：1998-11-11

Applicant: BAXTER INT

Inventor： BISCHOF DANIEL F ,  LIKENS MATTHEW E ,  GOLDHABER RICHARD P ,  DENIEGA JOSE C ,  DUFF DANIEL H

IPC: A61M1/34 ,  A61K35/14 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  B01D17/02 ,  B01D21/00 ,  B01D21/24 ,  B01D21/26 ,  B01D21/28 ,  B01D21/30 ,  B01D61/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/08 ,  B01D61/22

CPC classification number: B01D21/2405 ,  A61M1/265 ,  A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3496 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/082 ,  B01D17/0217 ,  B01D17/085 ,  B01D21/0012 ,  B01D21/26 ,  B01D2221/10

Abstract: Blood separation systems and methods draw whole blood from a blood donor selected from a population of blood donors. The whole blood of the selected blood donor has a known hematocrit value that varies within the population of blood donors according to morphology of the selected blood donor. The systems and methods operate a pump in the inlet line to convey a volume of whole blood from the donor at a commanded flow rate for processing into plasma constituent and concentrated red blood cells. The systems and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of the known hematocrit value of the selected donor. The systems and methods obtain, after processing the whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.

公开(公告)号：AU580584B2

公开(公告)日：1989-01-19

申请号：AU3933085

申请日：1985-01-23

Applicant: BAXTER INT

Inventor： BOCQUET JACQUES R ,  GOLDHABER RICHARD P ,  KERSTEN JEAN ,  MATHIAS JEAN-MARIE ,  PEARSON STEPHEN

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61J3/00 ,  A61J1/06

Abstract: A sterile, closed drug delivery system (10) is provided comprising a flexible container (12), a capsule (22) coupled to the flexible container and a standard glass drug vial (36) positioned within the capsule. The flexible container has a liquid diluent therein. The capsule has supporting legs (32-35) which extend inwardly from the capsule to support the vial and also a highly flexible, pleated cap (28) which enables the drug vial to be manually moved relative to the supporting legs. The capsule is coupled to the flexible container by means of a hollow spike (54) located within the capsule and a frangible member (58) located within the flexible container, which frangible member allows fluid passage only when it is broken. Manual pressing of the pleated cap moves the drug vial downwardly onto the spike, piercing the stopper of the drug vial. Once the frangible member is broken, there is sterile communication between the drug vial and the liquid diluent contents of the flexible container.