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    FLEXIBLE BAG ASSEMBLY FOR MAGNETIC SEPARATOR
    1.
    发明申请
    FLEXIBLE BAG ASSEMBLY FOR MAGNETIC SEPARATOR 审中-公开
    磁性分离器柔性袋组件

    公开(公告)号：WO9111716A3

    公开(公告)日：1991-09-05

    申请号：PCT/US9100664

    申请日：1991-01-31

    Applicant: BAXTER INT

    Inventor： HARDWICK R ALAN ,  JOHNSON KENNETH M ,  LYNN DANIEL R

    IPC: B01L3/00 ,  B03C1/28 ,  G01N35/00 ,  G01N33/543 ,  B03C1/035

    CPC classification number: B01L3/505 ,  B03C1/288 ,  G01N35/0098

    Abstract: A flexible container arrangement useful for performing the magnetic separation of paramagnetic particles from a heterogeneous biological mixture. The flexible container arrangement of the invention includes two or more flexible containers (20, 22) having inlet and outlet ports. A flexible conduit (32) is connected between an outlet port of a first container and an inlet port of a second container. Another flexible conduit (32) is connected to an outlet port of the second container to allow for the discharge of fluid. The second flexible container (20, 22) is designed to provide for a reduction in fluid velocity at a rate of from about 1/7 to about 1/3 of the fluid velocity through the outlet conduit. The second container (20, 22) is also designed to provide a depth of fluid flow of about 0.02 to about 0.04 inch.

    METHOD AND APPARATUS FOR SEMI-AUTOMATED CELL SEPARATION
    3.
    发明公开
    METHOD AND APPARATUS FOR SEMI-AUTOMATED CELL SEPARATION 失效
    VERFAHREN UND APPARAT ZUM SEMI-AUTOMATISIERTES TRENNEN VON ZELLEN

    公开(公告)号：EP0697916A4

    公开(公告)日：1996-06-26

    申请号：EP95912699

    申请日：1995-03-03

    Applicant: BAXTER INT

    Inventor： MOUBAYED AHMAD-MAHER ,  BURGESS JULIE D ,  LAW PING ,  KULCINSKI DAVID L ,  HARDWICK R ALAN

    IPC: G01N33/53 ,  A61M1/02 ,  A61M1/36 ,  B03C1/00 ,  B03C1/02 ,  B03C1/28 ,  C12M1/26 ,  C12M1/42 ,  C12M3/00 ,  C12N5/06 ,  C12N13/00 ,  G01N33/49 ,  G01N33/543 ,  B03C1/01 ,  B03C1/32 ,  G01N33/553

    CPC classification number: C12M47/04 ,  A61M1/0209 ,  A61M1/3618 ,  A61M1/362 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/28 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N33/491

    Abstract: An apparatus and method for performing a magnetic cell separation process using paramagnetic beads, and having multiple steps or activitites which are required to complete the process successfully includes using a programmable machine (10) to either perform selected ones of the multiple steps itself; or to prompt a human attendant to perform others of said steps in sequence and to thereafter provide to the machine a verification input that the step to be performed by the human attendant is completed. The repeatability and reliability of the process when performed by the programmable machine (10) is vastly improved in comparison to conventional laboratory practice. Additionally, the programming of the machine (10) may be altered by super visory personnel to improve the efficacy of the process, or to customize the process for the separation of a particular type of cell.

    Abstract translation: 一种使用顺磁珠执行磁性细胞分离过程并且具有成功完成该过程所需的多个步骤或活性的装置和方法包括使用可编程机器（10）来自己执行多个步骤中的选定步骤; 或者促使人类助理顺序地执行所述步骤中的其他步骤，并且随后向机器提供验证输入，以使得完成由人工助理执行的步骤。 与传统的实验室实践相比，由可编程机器（10）执行的过程的可重复性和可靠性大大提高。 此外，机器（10）的编程可以由超级观察员改变以改进过程的效力，或者定制用于分离特定类型的细胞的过程。

    SYSTEM FOR SELECTIVE CELL SEPARATION FROM CELL CONCENTRATE
    4.
    发明专利
    SYSTEM FOR SELECTIVE CELL SEPARATION FROM CELL CONCENTRATE 未知

    公开(公告)号：CA1335181C

    公开(公告)日：1995-04-11

    申请号：CA614111

    申请日：1989-09-28

    Applicant: BAXTER INT

    Inventor： HARDWICK R ALAN ,  LAKE WILLIAM C ,  PRISCO MICHAEL R

    IPC: C12M3/00 ,  A61K35/14 ,  A61K35/28 ,  A61M1/02 ,  A61M1/36 ,  C12N5/02 ,  C12N5/06 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  C12N5/00 ,  B03C1/02

    Abstract: A system for the selective separation of a specific cel population from a heterogeneous cell mixture is disclosed herein. Means are provided for obtaining a selective cell concentrate from the heterogeneous cell mixture by separating the selective cell concentrate based upon the physical or biological properties of the concentrate. This may be done by centrifugation, if desired. A container is provided having particle means, the particle means being attached to a substance that is active for binding to a specific desired cell. One brings the cell concentrate into contact with the particle means within the container, for example, by providing sterile connection between the site where the cell concentrate is formed and the container. This permits incubation of the cell concentrate with the particle means, to thereby selectively bind a specific cell population from the cell concentrate to the particle means, creating a particle/cell conjugate. Magnetic means are then provided for separating the particle/cell conjugate from the remainder of the cell concentrate. A two-magnet system may be used to form the separation.

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