Abstract:
Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.
Abstract:
A flexible container arrangement useful for performing the magnetic separation of paramagnetic particles from a heterogeneous biological mixture. The flexible container arrangement of the invention includes two or more flexible containers (20, 22) having inlet and outlet ports. A flexible conduit (32) is connected between an outlet port of a first container and an inlet port of a second container. Another flexible conduit (32) is connected to an outlet port of the second container to allow for the discharge of fluid. The second flexible container (20, 22) is designed to provide for a reduction in fluid velocity at a rate of from about 1/7 to about 1/3 of the fluid velocity through the outlet conduit. The second container (20, 22) is also designed to provide a depth of fluid flow of about 0.02 to about 0.04 inch.
Abstract:
Systems and methods for collecting blood substantially free of undesired matter assure that accurate crossmatching and typing of cellular blood components can be done prior to transfusion, even though the cellular components are collected and stored in different containers. The blood containing the undesired matter is collected in a blood collection container (16) including a tube (22) that is sealed for retaining samples of the collected blood for later analysis. The collected blood is conveyed out of the blood collection container (16) for removal of undesired matter and is collected in a separate transfer container (34) for storage. The distal end (29) of the sealed tube (22) containig the blood samples is attached to the transfer container (34), while other end of the sealed tube (22) is disconnected from the original blood collection container (16), thereby, leaving the sealed tube (22) with the retained blood sample attached only to the transfer container (34).
Abstract:
Systems and methods of collecting blood cells use a first container (16) connected to initially collect blood. A filtration system (14) is provided that uses two flow paths (34, 38), the first (38) being a dual purpose path that is initially used to convey plasma and platelets to a pair of transfer/storage containers (30, 32). A second flow path (34) leads to a temporary transfer container (28) through a filtration device (36). The dual purpose fluid path (38) is next used to convey blood cells, not substantially free of undesired matter, from the temporary storage container (28) to a storage container (18). The filtration system (14) is then detached from the blood collection system (12).
Abstract:
Systems and methods of collecting blood cells use a first container (16) connected to at least three transfer containers (18, 26, 34). A filtration system (10) is provided with one transfer container (34), which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers (18, 26) are connected to each other, one (18) of which is empty and one (26) or which contains an additive solution (5) for storage of red blood cells. The empty transfer container (18) is used for storage of platelet concentrate, while the container (26) that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution (5) may be separately passed through the filtration system (10) after filtration of the red cells to flush additional red blood cells from the filtration device (40).
Abstract:
Apparatus and methods of collecting blood cells use a first container (16) to collect and separate blood. A filtration system (14) is provided that has a first, dual purpose, flow path (38) that is initially used to convey plasma and platelets from the first container (16) to a pair of transfer/storage containers (30,32). A second flow path (34) leads to a temporary transfer container (28) through a filtration device (36). The dual purpose fluid path (38) is next used to convey blood cells, now substantially freed of undesired matter by the filtration device, from the temporary storage container (28) to a satellite storage container (18) along a path that bypasses the first container (16), thereby avoiding contamination of the filtered blood cells by residual undesired matter in the first container (16).
Abstract:
Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.
Abstract:
Apparatus and methods of collecting blood cells use a first container (16) to collect and separate blood. A filtration system (14) is provided that has a first, dual purpose, flow path (38) that is initially used to convey plasma and platelets from the first container (16) to a pair of transfer/storage containers (30,32). A second flow path (34) leads to a temporary transfer container (28) through a filtration device (36). The dual purpose fluid path (38) is next used to convey blood cells, now substantially freed of undesired matter by the filtration device, from the temporary storage container (28) to a satellite storage container (18) along a path that bypasses the first container (16), thereby avoiding contamination of the filtered blood cells by residual undesired matter in the first container (16).
Abstract:
2086604 9220429 PCTABS00017 Systems and methods for collecting blood substantially free of undesired matter assure that accurate crossmatching and typing of cellular blood components can be done prior to transfusion, even though the cellular components are collected and stored in different containers. The blood containing the undesired matter is collected in a blood collection container (16) including a tube (22) that is sealed for retaining samples of the collected blood for later analysis. The collected blood is conveyed out of the blood collection container (16) for removal of undesired matter and is collected in a separate transfer container (34) for storage. The distal end (29) of the sealed tube (22) containig the blood samples is attached to the transfer container (34), while other end of the sealed tube (22) is disconnected from the original blood collection container (16), thereby, leaving the sealed tube (22) with the retained blood sample attached only to the transfer container (34).
Abstract:
Treatment apparatus, system and method are disclosed for treating a biological fluid, such as blood or blood components. The treatment may include but isnot limited to inactivation of pathogens in red cell concentrate. The system may include a disposable fluid circuit assembly and a reusable controller that controls flow through the fluid circuit for reconstituting, if necessary, a treating agent, combining the treating agent with a biological fluid and mixing the agent and biological fluid. An optional quenching agent may also be used.