公开(公告)号：WO9427698A3

公开(公告)日：1996-10-10

申请号：PCT/US9305735

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  B01D

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.

公开(公告)号：WO9104059A3

公开(公告)日：1992-02-20

申请号：PCT/US9005228

申请日：1990-09-14

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  SMITH ALAN K ,  LAKE WILLIAM C ,  CHENOWETH DENNIS

IPC: A61K39/395 ,  A61K47/48 ,  B03C1/00 ,  B03C1/28 ,  C07K1/14 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K16/00 ,  A61K49/00

CPC classification number: B03C1/288 ,  A61K47/68 ,  Y10S530/811

Abstract: A method, and useful apparatus for the preparation of pharmaceutical compositions comprising a complex of an antigen component and the corresponding antibody component in a pharmacologically acceptable carrier.

公开(公告)号：EP0653062A4

公开(公告)日：1997-12-03

申请号：EP93915369

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

公开(公告)号：DE68917736T2

公开(公告)日：1995-05-04

申请号：DE68917736

申请日：1989-10-10

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  LAKE WILLIAM C ,  PRISCO MICHAEL R

IPC: C12M3/00 ,  A61K35/14 ,  A61K35/28 ,  A61M1/02 ,  A61M1/36 ,  C12N5/02 ,  C12N5/06 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  B03C1/02

公开(公告)号：CA1335181C

公开(公告)日：1995-04-11

申请号：CA614111

申请日：1989-09-28

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  LAKE WILLIAM C ,  PRISCO MICHAEL R

IPC: C12M3/00 ,  A61K35/14 ,  A61K35/28 ,  A61M1/02 ,  A61M1/36 ,  C12N5/02 ,  C12N5/06 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  C12N5/00 ,  B03C1/02

Abstract: A system for the selective separation of a specific cel population from a heterogeneous cell mixture is disclosed herein. Means are provided for obtaining a selective cell concentrate from the heterogeneous cell mixture by separating the selective cell concentrate based upon the physical or biological properties of the concentrate. This may be done by centrifugation, if desired. A container is provided having particle means, the particle means being attached to a substance that is active for binding to a specific desired cell. One brings the cell concentrate into contact with the particle means within the container, for example, by providing sterile connection between the site where the cell concentrate is formed and the container. This permits incubation of the cell concentrate with the particle means, to thereby selectively bind a specific cell population from the cell concentrate to the particle means, creating a particle/cell conjugate. Magnetic means are then provided for separating the particle/cell conjugate from the remainder of the cell concentrate. A two-magnet system may be used to form the separation.

公开(公告)号：CA2140455A1

公开(公告)日：1994-12-08

申请号：CA2140455

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  A61K35/18 ,  A61K35/28 ,  B01D21/26 ,  C12N1/00

Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.

公开(公告)号：CA2067158A1

公开(公告)日：1991-03-15

申请号：CA2067158

申请日：1990-09-14

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  SMITH ALAN K ,  LAKE WILLIAM C ,  CHENOWETH DENNIS E

IPC: A61K39/395 ,  A61K47/48 ,  B03C1/00 ,  B03C1/28 ,  C07K1/14 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K16/00 ,  B03B1/00 ,  G01N33/543

Abstract: METHOD AND USEFUL APPARATUS FOR PREPARING PHARMACEUTICAL COMPOSITIONS A method, and useful apparatus for the preparation of pharmaceutical compositions comprising a complex of an antigen component and the corresponding antibody component in a pharmacologically acceptable carrier.

公开(公告)号：DE68917736D1

公开(公告)日：1994-09-29

申请号：DE68917736

申请日：1989-10-10

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  LAKE WILLIAM C ,  PRISCO MICHAEL R

IPC: C12M3/00 ,  A61K35/14 ,  A61K35/28 ,  A61M1/02 ,  A61M1/36 ,  C12N5/02 ,  C12N5/06 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  B03C1/02

公开(公告)号：DD298055A5

公开(公告)日：1992-02-06

申请号：DD34402690

申请日：1990-09-14

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  LAKE WILLIAM C ,  SMITH ALAN K ,  CHENOWETH DENNIS

IPC: A61K39/395 ,  A61K47/48 ,  B03C1/00 ,  B03C1/28 ,  C07K1/14 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K16/00 ,  A61K39/385 ,  A61M1/36 ,  G01N33/543

公开(公告)号：PL286914A1

公开(公告)日：1991-08-12

申请号：PL28691490

申请日：1990-09-14

Applicant: BAXTER INT

Inventor： HARDWICK R ALAN ,  SMITH ALAN K ,  LAKE WILLIAM C ,  CHENOWETH DENNIS

IPC: A61K39/395 ,  A61K47/48 ,  B03C1/00 ,  B03C1/28 ,  C07K1/14 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K16/00 ,  A61K39/00