公开(公告)号：AU1259292A

公开(公告)日：1992-09-15

申请号：AU1259292

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA ,  ROSEMAN THEODORE ,  WOOD RAY W

IPC: A61K9/127

公开(公告)号：AU656173B2

公开(公告)日：1995-01-27

申请号：AU1259292

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA ,  ROSEMAN THEODORE ,  WOOD RAY W

IPC: A61K9/127 ,  A61K9/133

公开(公告)号：CA2079450A1

公开(公告)日：1992-08-15

申请号：CA2079450

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA ,  ROSEMAN THEODORE ,  WOOD RAY W

IPC: A61K9/127

Abstract: 2079450 9214446 PCTABS00015 Recognizing substances, epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular target site. These "bioadhesive" liposomes offer several advantages in the area of topically and locally administered free drug. These advantages include the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.