公开(公告)号：EP0606450A4

公开(公告)日：1996-06-05

申请号：EP93917203

申请日：1993-07-14

Applicant: BAXTER INT

Inventor： BANCSI JOSEPH A ,  ELLER CHARLES ,  FOWLES THOMAS A ,  GORMAN BRIAN J ,  HEBRON TERRENCE J ,  JERSILD CHARLES ,  JESS DONALD A ,  WONG JOSEPH C T ,  WOOD RAY W

IPC: A61J1/05 ,  A61J3/00 ,  A61M5/14 ,  A61M39/02 ,  A61B19/00

CPC classification number: A61M5/1409 ,  Y10S604/905

Abstract: The present invention provides an improved cannula (22) that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula (22) and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution of a powdered drug comprising a cannula (22) having a first end (26) and a second end (28), and defining a channel in an interior thereof between the first and second ends (26, 28). The first end (26) is closed and includes a member (27) for piercing a septum (42). The cannula (22) includes at least two slots (50a, 50b) providing fluid communication between the channel and an exterior of the cannula (22). The slots (50a, 50b) are located in juxtaposition to the first end (26) and have a width, as measured along a length of the cannula (22), that is less than a length, as measured around the cannula (22). The slots (50a, 50b) also have a minimum projected area equal to or greater than the cross-sectional area of the channel.

公开(公告)号：EP0623033A4

公开(公告)日：1995-05-24

申请号：EP93923201

申请日：1993-10-04

Applicant: BAXTER INT

Inventor： WONG JOSEPH ,  WOOD RAY W ,  MCSHANE JAMES

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00

CPC classification number: A61J1/2089 ,  A61J1/10 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2096 ,  A61M5/1409 ,  A61M5/282 ,  A61M5/284

Abstract: A drug delivery device (10) is provided for coupling a first container (54) including a beneficial agent to a second member (64). In an embodiment, the device (10) includes a substantially hollow member (12) having a cannula (26) mounted within a wall (14) that divides the substantially hollow member (12) into a first and second section (16, 18). The first section (16) includes means forreceiving at least a portion of a first container (54). The substantially hollow member (12) includes a wall (60) that defines an exterior of the first section (16) that is substantially flexible. A number of different cannula and flow path structures within the hollow member (12) are possible pursuant to the present invention.

公开(公告)号：EP0680358A4

公开(公告)日：1996-07-31

申请号：EP94931282

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

CPC classification number: A61M5/284 ,  A61J1/10 ,  A61J1/1475 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2089 ,  A61J1/2096 ,  A61M5/1409 ,  A61M5/282

Abstract: A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).

公开(公告)号：DK0621948T3

公开(公告)日：1999-06-23

申请号：DK94900496

申请日：1993-11-03

Applicant: BAXTER INT

Inventor： CRAWFORD JOHN W ,  HANSEN LEE D ,  WOOD RAY W

IPC: G01N25/48 ,  G01N25/56

Abstract: A method of determining the critical vapor pressure of a hygroscopic material, such as a drug. A drug sample is placed in a substantially isothermal environment. A vapor, such as water vapor, at a given pressure is then placed in the ambient air over the drug. The rate of heat production from this sample at the given water vapor pressure, or the humidity of the air above the sample, is then measured. The water vapor pressure over the drug is gradually increased. Simultaneously, the rate of increase in heat production from the drug sample, or the rate of change of the relative humidity of the air above the drug sample, is measured. A marked increase in the rate of heat production generated by the drug, or a marked change in the relative humidity of the air over the sample, signals the attainment of the critical water vapor pressure.

公开(公告)号：AU1259292A

公开(公告)日：1992-09-15

申请号：AU1259292

申请日：1991-10-30

Applicant: BAXTER INT

Inventor： MARGALIT RIMONA ,  ROSEMAN THEODORE ,  WOOD RAY W

IPC: A61K9/127

公开(公告)号：AU8010794A

公开(公告)日：1995-06-13

申请号：AU8010794

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

公开(公告)号：CA2119124A1

公开(公告)日：1994-02-17

申请号：CA2119124

申请日：1993-07-14

Applicant: BAXTER INT

Inventor： BANCSI JOSEPH A ,  ELLER CHARLES ,  FOWLES THOMAS A ,  GORMAN BRIAN J ,  HEBRON TERRENCE J ,  JERSILD CHARLES ,  JESS DONALD A ,  WONG JOSEPH C T ,  WOOD RAY W

IPC: A61J1/05 ,  A61J3/00 ,  A61M5/14 ,  A61M39/02 ,  A61J1/20 ,  B65D25/08

Abstract: The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.

公开(公告)号：AU664770B2

公开(公告)日：1995-11-30

申请号：AU4679493

申请日：1993-07-14

Applicant: BAXTER INT

Inventor： BANCSI JOSEPH A ,  ELLER CHARLES ,  FOWLES THOMAS A ,  GORMAN BRIAN J ,  HEBRON TERRENCE J ,  JERSILD CHARLES ,  JESS DONALD A ,  WONG JOSEPH C T ,  WOOD RAY W

IPC: A61J1/05 ,  A61J3/00 ,  A61M5/14 ,  A61M39/02 ,  A61M5/162 ,  A61M39/00 ,  A61J1/20

Abstract: The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.

公开(公告)号：CA2152586A1

公开(公告)日：1995-06-01

申请号：CA2152586

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： THOMPSON STACEY S ,  MCSHANE JAMES ,  WONG JOSEPH ,  WOOD RAY W

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00 ,  A61M39/00

Abstract: A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).

公开(公告)号：AU5296693A

公开(公告)日：1994-06-08

申请号：AU5296693

申请日：1993-10-04

Applicant: BAXTER INT

Inventor： WONG JOSEPH ,  WOOD RAY W ,  MCSHANE JAMES

IPC: A61J1/05 ,  A61J1/00 ,  A61J1/20 ,  A61M5/14 ,  A61M5/28 ,  A61M37/00

Abstract: A drug delivery device is provided for coupling a first container including a beneficial agent to a second member. In an embodiment, the device includes a substantially hollow member having a cannula mounted within a wall that divides the substantially hollow member into a first and second section. The first section includes means for receiving at least a portion of a first container. The substantially hollow member includes a wall that defines an exterior of the first section that is substantially flexible. A number of different cannula and flow path structures within the hollow member are possible pursuant to the present invention.