公开(公告)号：WO0041718A9

公开(公告)日：2001-09-20

申请号：PCT/US0000410

申请日：2000-01-10

Applicant: BAXTER INT

Inventor： KAROOR SUJATHA ,  HENDERSON LEE ,  MOLINA JEANETTE

IPC: A61M1/34 ,  A61P37/06 ,  B01J20/28 ,  B01J20/32 ,  A61K39/00

CPC classification number: A61M1/3486 ,  A61M1/3472 ,  A61M1/3475 ,  B01J20/28033 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274

Abstract: A method and apparatus for selectively removing xenoreactive antibodies from blood, serum or plasma are provided wherein a ligand capable of binding to xenoreactive antibodies is immobilized to an immunoaffinity membrane, and the blood, serum or plasma is passed through the ligand-containing immunoaffinity membrane so that xenoreactive antibodies are removed from the blood, serum or plasma prior to its reintroduction into a patient. The invention allows for specific removal of only those xenoreactive antibodies associated with the hyperacute rejection observed when organs or tissues from certain non-human animals come in contact with human blood or blood fluids, as would occur during xenotransplantation. The invention is advantageous in that it can be carried out simply and efficiently using a single piece of equipment, and the invention will be useful in reducing or eliminating the hyperacute rejection and rapid destruction of graft tissue that would normally occur following xenotransplantation.

Abstract translation: 提供了一种从血液，血清或血浆中选择性去除异反应性抗体的方法和装置，其中能够结合异反应性抗体的配体被固定在免疫亲和膜上，血液，血清或血浆通过含配体的免疫亲和膜 在将其再次引入患者之前，从血液，血清或血浆中除去异反应性抗体。 如在异种移植期间发生的那样，本发明允许特异性地去除与来自某些非人类动物的器官或组织接触人类血液或血液的超急性排斥相关的那些异反应性抗体。 本发明的优点在于其可以使用单件设备简单有效地进行，并且本发明可用于减少或消除通常在异种移植后发生的超急性排斥和移植组织的快速破坏。