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1.发明申请METHOD AND APPARATUS FOR SELECTIVELY REMOVING XENOREACTIVE ANTIBODIES FROM BLOOD, SERUM OR PLASMA 审中-公开从血液，血清或血浆中选择性地去除感冒性抗体的方法和装置
公开(公告)号：WO0041718A9
公开(公告)日：2001-09-20
申请号：PCT/US0000410
申请日：2000-01-10
Applicant: BAXTER INT
Inventor： KAROOR SUJATHA , HENDERSON LEE , MOLINA JEANETTE
CPC classification number: A61M1/3486 , A61M1/3472 , A61M1/3475 , B01J20/28033 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274
Abstract: A method and apparatus for selectively removing xenoreactive antibodies from blood, serum or plasma are provided wherein a ligand capable of binding to xenoreactive antibodies is immobilized to an immunoaffinity membrane, and the blood, serum or plasma is passed through the ligand-containing immunoaffinity membrane so that xenoreactive antibodies are removed from the blood, serum or plasma prior to its reintroduction into a patient. The invention allows for specific removal of only those xenoreactive antibodies associated with the hyperacute rejection observed when organs or tissues from certain non-human animals come in contact with human blood or blood fluids, as would occur during xenotransplantation. The invention is advantageous in that it can be carried out simply and efficiently using a single piece of equipment, and the invention will be useful in reducing or eliminating the hyperacute rejection and rapid destruction of graft tissue that would normally occur following xenotransplantation.
Abstract translation: 提供了一种从血液，血清或血浆中选择性去除异反应性抗体的方法和装置，其中能够结合异反应性抗体的配体被固定在免疫亲和膜上，血液，血清或血浆通过含配体的免疫亲和膜 在将其再次引入患者之前，从血液，血清或血浆中除去异反应性抗体。 如在异种移植期间发生的那样，本发明允许特异性地去除与来自某些非人类动物的器官或组织接触人类血液或血液的超急性排斥相关的那些异反应性抗体。 本发明的优点在于其可以使用单件设备简单有效地进行，并且本发明可用于减少或消除通常在异种移植后发生的超急性排斥和移植组织的快速破坏。
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公开(公告)号：DE69419095D1
公开(公告)日：1999-07-22
申请号：DE69419095
申请日：1994-02-28
Applicant: BAXTER INT
Inventor： OFSTHUN NORMA , HENDERSON LEE , BROWN RICHARD , PAULEY ROBIN
Abstract: The invention provides dual-skinned membrane useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200,000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.
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公开(公告)号：DE69419095T2
公开(公告)日：2000-02-03
申请号：DE69419095
申请日：1994-02-28
Applicant: BAXTER INT
Inventor： OFSTHUN NORMA , HENDERSON LEE , BROWN RICHARD , PAULEY ROBIN
Abstract: The invention provides dual-skinned membrane useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200,000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.
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