公开(公告)号：WO9115253A3

公开(公告)日：1992-01-09

申请号：PCT/US9102192

申请日：1991-03-28

Applicant: BAXTER INT

Inventor： FORD MICHAEL G ,  PRINCE PAUL R

IPC: A61M1/02 ,  A61M1/34 ,  A61M5/168 ,  G01G17/04

CPC classification number: A61M5/16809 ,  A61M1/3451 ,  A61M5/16845 ,  A61M2205/3393 ,  G01G17/04

Abstract: A system (8) is provided for weighing and monitoring flow from multiple fluid sources (76) into a flow system (10) wherein incoming fluid is received in a weighing bag (80) attached to a control system for monitoring the amount of fluid passed through the weighing bag (80) and for preventing admission of air into the flow system (10). An alarm attached to the weighing bag (80) warns when fluid in the weighing bag (80) is approaching empty, so that the fluid in the weighing bag (80) can be replenished from the fluid source (76) before the weighing bag (80) runs dry. If fluid in the weighing bag (80) is not replenished, the system automatically shuts down. The fluid pump (72) can be absolutely calibrated using the controlled admission of known amounts of fluids into the weighing bag (80) so that the amount of fluid introduced into the flow system (10) through the weighing bag (80) can be calculated automatically.

Abstract translation: 流体从源容器流动到称重容器，并从称重容器流出，流向称重容器的流量被控制以将称重容器中的流体重量保持在预定的限度内。 如果称重容器中的量低于警告量，则可以提供警告，然后液体从不同的源被引导到容器。 如果重量低于故障安全量，称量容器的流量可能会关闭。

公开(公告)号：EP0877648A4

公开(公告)日：2002-10-09

申请号：EP97944406

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： PRINCE PAUL R ,  PEKKARINEN MICHAEL O ,  BELLAMY DAVID JR ,  STERNBERG SHMUEL

IPC: A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02 ,  B01D65/02

CPC classification number: B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

Abstract translation: 一种用于过滤医疗和生物流体悬浮液的方法和装置，其一个方面是分离包含不同尺寸或形状的至少两种类型的颗粒的悬浮液，其中第一类型的颗粒可以以相对较低的力 和/或比第二类型的粒子更快的速率。 提供具有基本上精确尺寸的孔径的过滤构件，其中孔的尺寸被确定为允许第一类型的悬浮颗粒通过而没有变形，或仅仅具有基本变形的第二类型的颗粒的最小变形和通过。 因为过滤膜具有精确尺寸的孔，尽管孔之间的间隔较小，孔之间的间隔保持，但是膜的孔隙率可能比标称孔径膜大得多，允许较快的过滤速率和/或更小的膜用于 给定过滤速率，同时减少细胞在剪切环境中的暴露时间，从而减少颗粒损伤。 还公开了防止膜堵塞的各种方法。

公开(公告)号：DE3854927D1

公开(公告)日：1996-02-29

申请号：DE3854927

申请日：1988-11-22

Applicant: BAXTER INT

Inventor： SCHOENDORFER DONALD W ,  PRINCE PAUL R

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M1/38

公开(公告)号：CA1328825C

公开(公告)日：1994-04-26

申请号：CA584043

申请日：1988-11-24

Applicant: BAXTER INT

Inventor： SCHOENDORFER DONALD W ,  PRINCE PAUL R

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  A61M1/38

Abstract: SINGLE NEEDLE CONTINUOUS HEMAPHERESIS APPARATUS AND METHODS Blood separation is accomplished by alternately extracting blood from and reinfusing blood into a donor by way of a single needle while simultaneously and continuously separating the extracted blood into constituents. A harness set applicable to a hemapheresis instrument includes a dual-compartment reservoir. A first compartment stores blood during extraction for supply to the separator during reinfusion. The second compartment stores packed cells during collection for return to the donor during reinfusion. The collection and reinfusion cycles are alternated rapidly to preclude clotting in the un-anticoagulated portion of the harness tubing between the venepuncture needle and the Y-connection with the anticoagulant line.

公开(公告)号：AU621590B2

公开(公告)日：1992-03-19

申请号：AU3056989

申请日：1989-02-02

Applicant: BAXTER INT

Inventor： PRINCE PAUL R

IPC: G01N33/48 ,  A61M1/26 ,  A61M1/34 ,  B01D61/00 ,  B01D61/22 ,  B01D63/16 ,  B04B5/00 ,  B01D13/00

公开(公告)号：ES2277360T3

公开(公告)日：2007-07-01

申请号：ES97944406

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： PRINCE PAUL R ,  PEKKARINEN MICHAEL O ,  BELLAMY DAVID JR ,  STERNBERG SHMUEL

IPC: B01D65/02 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02

Abstract: LA INVENCION SE REFIERE A UN METODO Y A UN APARATO PARA FILTRAR SUSPENSIONES DE FLUIDOS MEDICOS Y BIOLOGICOS, UN ASPECTO DE LA CUAL CONSISTE EN SEPARAR UNA SUSPENSION QUE COMPRENDA AL MENOS DOS TIPOS DE PARTICULAS (104) Y (108), CON TAMAÑO Y FORMA DISTINTOS, EN LA QUE UN PRIMER TIPO, FORMADO POR PARTICULAS HEMATIES (104) SE PUEDE DEFORMAR CON UNA FUERZA RELATIVAMENTE INFERIOR Y/O A MAYOR VELOCIDAD QUE UN SEGUNDO TIPO DE PARTICULAS, FORMADO POR LEUCOCITOS (108). SE FACILITA UNA MEMBRANA FILTRANTE (100) DOTADA DE POROS (102), LOS CUALES SON SUSTANCIALMENTE DE UNA DIMENSION PRECISA; LA DIMENSION DE ESTOS POROS (102) ES TAL QUE PERMITA EL PASO DEL PRIMER TIPO DE PARTICULAS (104) SIN DISTORSION O CON UNA DISTORSION MINIMA Y, QUE EL SEGUNDO TIPO DE PARTICULAS (108) PASE SOLO CON UNA DISTORSION SUSTANCIAL. DEBIDO A QUE LA MEMBRANA FILTRANTE (100) TIENE UNOS POROS DIMENSIONADOS CON PRECISION (102), CUYA SEPARACION ENTRE POROS (102) SE MANTIENE A PESAR DE LA SEPARACION MENOR ENTRE LOS POROS (102), LA POROSIDAD DE LA MEMBRANA (100) PUEDE SER RELATIVAMENTE MUCHO MAYOR, PERMITIENDO UNAS VELOCIDADES DE FILTRADO MAYORES, A LA VEZ QUE REDUCE EL TIEMPO DE EXPOSICION AL CIZALLAMIENTO Y, EN CONSECUENCIA, SE REDUCE EL DAÑO A LAS PARTICULAS. TAMBIEN SE MUESTRAN VARIOS METODOS PARA EVITAR LA OBTURACION DE LA MEMBRANA (100).

公开(公告)号：DK0704224T3

公开(公告)日：2002-05-27

申请号：DK95203214

申请日：1991-03-28

Applicant: BAXTER INT

Inventor： FORD MICHAEL G ,  PRINCE PAUL R

IPC: A61M1/02 ,  A61M1/34 ,  A61M5/168 ,  G01G17/04 ,  A61M1/36

Abstract: Fluid is flowed from a source container to a weighing container and from the weighing container, the flow to the weighing container being controlled to keep the weight of fluid in the weighing container within predetermined limits. A warning may be provided if the amount in the weighing container falls below a warning amount, fluid then being directed to the container from a different source. Flow from the weighing container may be shut down, if the weight falls below a fail safe amount.

公开(公告)号：AT213652T

公开(公告)日：2002-03-15

申请号：AT95203214

申请日：1991-03-28

Applicant: BAXTER INT

Inventor： FORD MICHAEL G ,  PRINCE PAUL R

IPC: A61M1/02 ,  A61M1/34 ,  A61M5/168 ,  G01G17/04 ,  A61M1/36

Abstract: Fluid is flowed from a source container to a weighing container and from the weighing container, the flow to the weighing container being controlled to keep the weight of fluid in the weighing container within predetermined limits. A warning may be provided if the amount in the weighing container falls below a warning amount, fluid then being directed to the container from a different source. Flow from the weighing container may be shut down, if the weight falls below a fail safe amount.

公开(公告)号：CA2109837C

公开(公告)日：1998-07-14

申请号：CA2109837

申请日：1991-06-26

Applicant: BAXTER INT

Inventor： PRINCE PAUL R ,  MILLER WILLIAM ,  BENJAMIN GRANT STEVEN

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/34

Abstract: A simplified fluid separation method and device usable for various apheresis procedures, including plasmapheresis. At least one pump is utilized to draw a first fluid (e.g. whole blood) into a separation device. The separation device then operates to separate the fluid (e.g. whole blood) into first and second fluid fractions (e.g. a cell concentrate and blood plasma). The first and second fluid fractions are pumped from the separation device to separation first and second fluid fraction containers, both of which are positioned on a single weighing device, such as an electronic load cell. At least one of the fluid fractions is subsequently removed from its fluid fraction container and returned to the human subject or other fluid source. Weights recorded by the single weighing device are then utilized to calculate the actual weights of fluid and/or fluid fractions pumped by at least one pump during the procedure. Such actual weights of fluid and/or fluid fractions are then utilized to calculate new pump flow constants, thereby enabling the calibration of the pump(s) to be corrected, on the basis of such new pump flow constants, prior to subsequent utilization of the pump(s) for pumping the fluid and/or fluid fractions. The single weighing device may also be utilized to monitor the weight change or rate of weight change occurring as the fluid fractions are pumped into and/or out of the fluid fraction containers, thereby providing a means for monitoring and verifying the pressures and flow rates within the system.

公开(公告)号：CA2237019C

公开(公告)日：2006-05-16

申请号：CA2237019

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL ,  BELLAMY DAVID JR ,  PRINCE PAUL R ,  PEKKARINEN MICHAEL O

IPC: B01D69/02 ,  A61K35/14 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.