公开(公告)号：EP0877648A4

公开(公告)日：2002-10-09

申请号：EP97944406

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： PRINCE PAUL R ,  PEKKARINEN MICHAEL O ,  BELLAMY DAVID JR ,  STERNBERG SHMUEL

IPC: A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02 ,  B01D65/02

CPC classification number: B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

Abstract translation: 一种用于过滤医疗和生物流体悬浮液的方法和装置，其一个方面是分离包含不同尺寸或形状的至少两种类型的颗粒的悬浮液，其中第一类型的颗粒可以以相对较低的力 和/或比第二类型的粒子更快的速率。 提供具有基本上精确尺寸的孔径的过滤构件，其中孔的尺寸被确定为允许第一类型的悬浮颗粒通过而没有变形，或仅仅具有基本变形的第二类型的颗粒的最小变形和通过。 因为过滤膜具有精确尺寸的孔，尽管孔之间的间隔较小，孔之间的间隔保持，但是膜的孔隙率可能比标称孔径膜大得多，允许较快的过滤速率和/或更小的膜用于 给定过滤速率，同时减少细胞在剪切环境中的暴露时间，从而减少颗粒损伤。 还公开了防止膜堵塞的各种方法。

公开(公告)号：ES2277360T3

公开(公告)日：2007-07-01

申请号：ES97944406

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： PRINCE PAUL R ,  PEKKARINEN MICHAEL O ,  BELLAMY DAVID JR ,  STERNBERG SHMUEL

IPC: B01D65/02 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02

Abstract: LA INVENCION SE REFIERE A UN METODO Y A UN APARATO PARA FILTRAR SUSPENSIONES DE FLUIDOS MEDICOS Y BIOLOGICOS, UN ASPECTO DE LA CUAL CONSISTE EN SEPARAR UNA SUSPENSION QUE COMPRENDA AL MENOS DOS TIPOS DE PARTICULAS (104) Y (108), CON TAMAÑO Y FORMA DISTINTOS, EN LA QUE UN PRIMER TIPO, FORMADO POR PARTICULAS HEMATIES (104) SE PUEDE DEFORMAR CON UNA FUERZA RELATIVAMENTE INFERIOR Y/O A MAYOR VELOCIDAD QUE UN SEGUNDO TIPO DE PARTICULAS, FORMADO POR LEUCOCITOS (108). SE FACILITA UNA MEMBRANA FILTRANTE (100) DOTADA DE POROS (102), LOS CUALES SON SUSTANCIALMENTE DE UNA DIMENSION PRECISA; LA DIMENSION DE ESTOS POROS (102) ES TAL QUE PERMITA EL PASO DEL PRIMER TIPO DE PARTICULAS (104) SIN DISTORSION O CON UNA DISTORSION MINIMA Y, QUE EL SEGUNDO TIPO DE PARTICULAS (108) PASE SOLO CON UNA DISTORSION SUSTANCIAL. DEBIDO A QUE LA MEMBRANA FILTRANTE (100) TIENE UNOS POROS DIMENSIONADOS CON PRECISION (102), CUYA SEPARACION ENTRE POROS (102) SE MANTIENE A PESAR DE LA SEPARACION MENOR ENTRE LOS POROS (102), LA POROSIDAD DE LA MEMBRANA (100) PUEDE SER RELATIVAMENTE MUCHO MAYOR, PERMITIENDO UNAS VELOCIDADES DE FILTRADO MAYORES, A LA VEZ QUE REDUCE EL TIEMPO DE EXPOSICION AL CIZALLAMIENTO Y, EN CONSECUENCIA, SE REDUCE EL DAÑO A LAS PARTICULAS. TAMBIEN SE MUESTRAN VARIOS METODOS PARA EVITAR LA OBTURACION DE LA MEMBRANA (100).

公开(公告)号：CA2237019A1

公开(公告)日：1998-04-02

申请号：CA2237019

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL ,  PEKKARINEN MICHAEL O ,  PRINCE PAUL R ,  BELLAMY DAVID JR

IPC: A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00 ,  B01D69/02 ,  A61K35/14

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.

公开(公告)号：CA2237019C

公开(公告)日：2006-05-16

申请号：CA2237019

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL ,  BELLAMY DAVID JR ,  PRINCE PAUL R ,  PEKKARINEN MICHAEL O

IPC: B01D69/02 ,  A61K35/14 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.

公开(公告)号：CA2311321A1

公开(公告)日：1999-06-10

申请号：CA2311321

申请日：1998-11-11

Applicant: BAXTER INT

Inventor： BELLAMY DAVID JR ,  WOLF LUDWIG JR

IPC: B65D30/22 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61M1/02 ,  B29C49/00 ,  B29C51/00 ,  B29C65/00 ,  B29C65/18 ,  B31B50/59

Abstract: A flexible container (10) comprises first and second flexible sheets (52, 54) having peripheral edges, which have been sealed together along a plane by a peripheral seal (28) to create an interior chamber (12, 14) in the container. At least one of the first and second flexible sheets includes a preformed, stress-relieved region (48, 50) which is extended outside the plane and overlies at least a portion of the interior chamber.