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公开(公告)号：WO2010022320A3
公开(公告)日：2010-08-19
申请号：PCT/US2009054595
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
CPC classification number: A61K47/48215 , A61K31/405 , A61K47/60
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
Abstract translation: 本发明涉及聚合衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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公开(公告)号：NZ591045A
公开(公告)日：2013-01-25
申请号：NZ59104509
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SANDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Abstract: Disclosed is a compound of Formula I e.g. 4-(((2,5-dioxopyrrolidin-1-yloxy)carbonyloxy )methyl)phenyl 4-(2-methoxypolyethoxy)-2-methylbutanoate wherein the substituents are defined in the specification.
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Patent Agency Ranking
公开(公告)号：CA2731184C
公开(公告)日：2017-03-21
申请号：CA2731184
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SANDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
IPC: C07C69/708 , A61P7/00 , C07C69/63 , C08G65/333
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. Examples of drug conjugates described include conjugates of Formula II: (see formula II)
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公开(公告)号：BRPI0917819A2
公开(公告)日：2015-11-24
申请号：BRPI0917819
申请日：2009-08-21
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： AMBROISE AROUNAGUIRY , MELNICK BENNETT , QUINN CATHERINE , JIANG CONG , YANG GUOHAN , LI JIE , BROWN LARRY R , SANDERS PAUL , HAI TON THAT
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公开(公告)号：CA2731184A1
公开(公告)日：2010-02-25
申请号：CA2731184
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SANDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
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公开(公告)号：MX2011001887A
公开(公告)日：2011-04-04
申请号：MX2011001887
申请日：2009-08-21
Applicant: BAXTER INT
Inventor： HAI TON THAT , SANDERS PAUL , JIANG CONG , BROWN LARRY R , YANG GUOHAN , MELNICK BENNETT , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY
Abstract: La presente invención se refiere a derivados poliméricos, los cuales pueden ser conjugados a un medicamento conteniendo amino para mejorar sus propiedades in vivo. El derivado polimérico puede ser liberado subsecuentemente para producir el medicamento en su forma natural. Se describen métodos para preparar y usar estos derivados poliméricos y conjugados de medicamento.
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公开(公告)号：AU2009282747A1
公开(公告)日：2010-02-25
申请号：AU2009282747
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
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