公开(公告)号：WO2010022320A3

公开(公告)日：2010-08-19

申请号：PCT/US2009054595

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SAUNDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SAUNDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

CPC classification number: A61K47/48215 ,  A61K31/405 ,  A61K47/60

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Abstract translation: 本发明涉及聚合衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。

公开(公告)号：CA2793493A1

公开(公告)日：2011-10-20

申请号：CA2793493

申请日：2011-04-08

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： BUI TUAN ,  HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  LAMB DAVID ,  YARDIMCI OZLEM

IPC: A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61M39/02 ,  A61M39/16

Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

公开(公告)号：AU2013215237A1

公开(公告)日：2014-07-24

申请号：AU2013215237

申请日：2013-01-30

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： DOCKAL MICHAEL ,  SCHEIFLINGER FRITZ ,  KNAPPE SABINE ,  TILL SUSANNE ,  HAI TON ,  SANDERS PAUL ,  DANDE PRASAD ,  JIANG CONG

IPC: A61K31/715 ,  A61P7/04

Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting

公开(公告)号：NZ591045A

公开(公告)日：2013-01-25

申请号：NZ59104509

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

Abstract: Disclosed is a compound of Formula I e.g. 4-(((2,5-dioxopyrrolidin-1-yloxy)carbonyloxy )methyl)phenyl 4-(2-methoxypolyethoxy)-2-methylbutanoate wherein the substituents are defined in the specification.

公开(公告)号：MX2007000742A

公开(公告)日：2007-03-30

申请号：MX2007000742

申请日：2005-06-22

Applicant: BAXTER INT

Inventor： HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  KAROOR SUJATHA ,  MELNICK BEN

IPC: A61P39/06 ,  A61K31/355

Abstract: Se proveen composiciones terapeuticas. Las composiciones incluyen una molecula unica que puede exhibir propiedades secuestrantes y antioxidantes de carbonilo. Esto puede reducir efectivamente la inflamacion, el estres oxidativo y el estres de carbonilo, a fin de prevenir y/o tratar la enfermedad cardiovascular y las enfermedades inflamatorias en pacientes con enfermedades renales.

公开(公告)号：CA2731184C

公开(公告)日：2017-03-21

申请号：CA2731184

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: C07C69/708 ,  A61P7/00 ,  C07C69/63 ,  C08G65/333

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. Examples of drug conjugates described include conjugates of Formula II: (see formula II)

公开(公告)号：BRPI0917819A2

公开(公告)日：2015-11-24

申请号：BRPI0917819

申请日：2009-08-21

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： AMBROISE AROUNAGUIRY ,  MELNICK BENNETT ,  QUINN CATHERINE ,  JIANG CONG ,  YANG GUOHAN ,  LI JIE ,  BROWN LARRY R ,  SANDERS PAUL ,  HAI TON THAT

IPC: A61K47/48 ,  A61P7/00

公开(公告)号：CA2861077A1

公开(公告)日：2013-08-08

申请号：CA2861077

申请日：2013-01-30

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： DOCKAL MICHAEL ,  SCHEIFLINGER FRITZ ,  KNAPPE SABINE ,  TILL SUSANNE ,  HAI TON ,  SANDERS PAUL ,  DANDE PRASAD ,  JIANG CONG

IPC: A61K31/715 ,  A61P7/04

Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.

公开(公告)号：CA2731184A1

公开(公告)日：2010-02-25

申请号：CA2731184

申请日：2009-08-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： YANG GUOHAN ,  HAI TON THAT ,  MELNICK BENNETT ,  SANDERS PAUL ,  JIANG CONG ,  QUINN CATHERINE ,  LI JIE ,  AMBROISE AROUNAGUIRY ,  BROWN LARRY R

IPC: A61K47/48 ,  A61P7/00

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

公开(公告)号：AU2011240879A9

公开(公告)日：2013-01-24

申请号：AU2011240879

申请日：2011-04-08

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： BUI TUAN ,  HAI TON THAT ,  NORDHAUS MARK ,  SANDERS PAUL ,  JIANG CONG ,  LAMB DAVID ,  YARDIMCI OZLEM

IPC: A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61M39/02 ,  A61M39/16

Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.