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    SICKLE-CELL DIAGNOSTIC TEST
    6.
    发明专利
    SICKLE-CELL DIAGNOSTIC TEST 未知

    公开(公告)号：ZA731900B

    公开(公告)日：1973-12-19

    申请号：ZA731900

    申请日：1973-03-19

    Applicant: BAXTER LABORATORIES INC

    Inventor： LOUDERBACK A ,  YOUHNE Y ,  FONTANA A

    IPC: G01N33/72 ,  A61K

    Abstract: 1377346 Diagnostic agent for detecting sicklecell disease BAXTER LABORATORIES Inc 26 March 1973 [24 March 1972] 14443/73 Heading G1B A reagent kit for use in testing blood for sicklecell disease and for distinguishing between sicklecell anemia and sickle-cell trait comprises (a) an aqueous buffer solution having a pH of from 7 to 7À5 and containing, per 100 ml of solution, from 21 to 35 grams of (NH 4 ) 2 SO 4 and from 0À5 to 2À0 grams of K 2 HPO 4 , (b) a hemolyzing agent, for example saponin, and (c) a reducing agent, for example sodium dithionite. The hemolyzing agent and the reducing agent may be in powdered form. Reagent solution prepared by mixing the contents of such kit may contain, per 100 ml of solution, from 0À01 to 2 grams of hemolyzing agent and from 0À01 to 2 grams of reducing agent. A sample of unclotted blood is mixed with a predetermined amount of reagent solution, the mixture being observed visually both before and after centrifuging. A translucent solution before centrifuging indicates normal (AA) hemoglobin whereas a turbid solution indicates either sickle-cell trait (AS) hemoglobin or sickle-cell anemia (SS) hemoglobin; a small amount of white precipitate after centrifuging indicates normal hemoglobin whereas a pink solution with red precipitate indicates sickle-cell hemoglobin and a yellow solution with red precipitate indicates sickle-cell anemia hemoglobin. The buffer solution additionally may contain a redox dye, for example methylene blue or basic fuchsin, for indicating decomposition of sodium dithionite reducing agent.

    CEREBROSPINAL FLUID CONTROL STANDARD
    7.
    发明专利
    CEREBROSPINAL FLUID CONTROL STANDARD 未知

    公开(公告)号：ZA731898B

    公开(公告)日：1973-12-19

    申请号：ZA731898

    申请日：1973-03-19

    Applicant: BAXTER LABORATORIES INC

    Inventor： LOUNDERBACK A ,  FONTANA A

    IPC: G01N33/50 ,  G01N33/66 ,  G01N33/68 ,  G01N33/84 ,  G01N33/96 ,  A61K

    Abstract: 1372812 Standard for analysis BAXTER LABORATORIES Inc 26 March 1973 [24 March 1972] 14448/73 Heading G1B [Also in Division A5] A synthetic "cerebrospinal fluid" for use as a control standard in analysis comprises normal blood serum diluted, with an aqueous solution of 40 to 200 mg per 100 ml of glucose and 80 to 130 meq per litre of chloride ion, to a protein concentration range of 30 to 145 mg per 100 ml. Additional pre-albumin (obtained from blood serum) may be added. The composition may be lyophilized, preferably after adding some gum acacia.

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