公开(公告)号：US3754087A

公开(公告)日：1973-08-21

申请号：US3754087D

申请日：1969-11-12

Applicant: BAYER AG

Inventor： LEY K ,  KHOLZER U ,  FRITSCHE D ,  NAST R ,  METZGER K

IPC: C07D241/52 ,  A61K27/00

CPC classification number: C07D241/52

Abstract: 2-HALOMETHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE-1.4 DI-N-OXIDES OF THE FORMULA:

1,4-DI(O=),2-(HAL-CH2-),3-(R2-N(-R3)-CO-),R1-QUINOXALINE

WHEREIN: R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE R2 IS HYDREGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS HYDDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FROM PART OF A 5- OR 6MEMBRED HETEROCYCLIC RING, AND HAL IS CHLORINE OR BROMINE, IN COMBINATION WITH A PHARMACEUTICALLY ACCETABLE INERT CARRIER ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOSITIONS OR THE ACTIVE COMPOUND CAN BE ADMINISTERED SUBCUTANEOUSLY OR ORALLY TO HUMANS OR ANIMALS.