公开(公告)号：GB2246197A

公开(公告)日：1992-01-22

申请号：GB9115090

申请日：1991-07-12

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

Abstract: Immobilized macromolecules, such as proteins or nucleic acid sequences (12), are tagged with labels (13) which induce a chemiluminescent reaction in a liquid-phase substrate (15). As the reaction is occurring, the substrate is exposed to a phosphorescent screen (16) which absorbs the chemiluminescent emission in an image of the pattern formed by the macromolecules. The absorbed energy is then released and read, providing qualitative and optionally quantitative information regarding the immobilized macromolecules. Distinct labels, which react with a mixture of chemiluminescent substrates to emit light at correspondingly distinct wavelengths, may be used with a phosphorescent screen selectively excitable by light of said distinct wavelengths. By this method different macromolecules can be detected simultaneously.

公开(公告)号：DE4122839A1

公开(公告)日：1992-01-16

申请号：DE4122839

申请日：1991-07-10

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

公开(公告)号：CA2043631C

公开(公告)日：1998-04-21

申请号：CA2043631

申请日：1991-05-31

Applicant: BIO RAD LABORATORIES

Inventor： WITNEY FRANKLIN R ,  BERS GEORGE

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

Abstract: Immobilized macromolecules such as proteins or nucleic acid sequences are tagged with labels which induce a chemiluminescent reaction in a liquid-phase substrate. As the reaction is occurring, the substrate is exposed to a phosphor screen which absorbs the chemiluminescent emission in an image of the pattern formed by the macromolecules. The absorbed energy is then released and read, providing qualitative and optionally quantitative information regarding the immobilized macromolecules.

公开(公告)号：FR2664703B1

公开(公告)日：1995-05-12

申请号：FR9108381

申请日：1991-07-04

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68 ,  G01N33/52

公开(公告)号：HK40795A

公开(公告)日：1995-03-31

申请号：HK40795

申请日：1995-03-23

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

公开(公告)号：SG14195G

公开(公告)日：1995-06-16

申请号：SG14195

申请日：1995-01-26

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: G01N21/76

公开(公告)号：GB2246197B

公开(公告)日：1994-03-16

申请号：GB9115090

申请日：1991-07-12

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

公开(公告)号：CA2043631A1

公开(公告)日：1992-01-13

申请号：CA2043631

申请日：1991-05-31

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE ,  WITNEY FRANKLIN R

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68

Abstract: Immobilized macromolecules such as proteins or nucleic acid sequences are tagged with labels which induce a chemiluminescent reaction in a liquid-phase substrate. As the reaction is occurring, the substrate is exposed to a phosphor screen which absorbs the chemiluminescent emission in an image of the pattern formed by the macromolecules. The absorbed energy is then released and read, providing qualitative and optionally quantitative information regarding the immobilized macromolecules.

公开(公告)号：ITRM910741D0

公开(公告)日：1991-10-02

申请号：ITRM910741

申请日：1991-10-02

Applicant: BIO RAD LABORATORIES

Inventor： LAI ERIC ,  BIRREN BRUCE W ,  STUBBLEBINE WILL H ,  BERS GEORGE E ,  BERS GEORGE

IPC: B01D57/02 ,  G01N27/447

公开(公告)号：ITRM910503D0

公开(公告)日：1991-07-10

申请号：ITRM910503

申请日：1991-07-10

Applicant: BIO RAD LABORATORIES

Inventor： BERS GEORGE E ,  WITNEY FRANKLIN R ,  BERS GEORGE

IPC: C12Q1/42 ,  C12Q1/68 ,  G01N21/76 ,  G01N21/78 ,  G01N33/58 ,  G01N33/68