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1.发明专利
公开(公告)号：AU2006236403A1
公开(公告)日：2006-10-26
申请号：AU2006236403
申请日：2006-04-18
Applicant: BIO RAD LABORATORIES
Inventor： WATKINS MICHAEL , BINDER STEVEN , WOEI TAN , PRESTIGIACOMO TONY
IPC: G01N33/567 , G01N33/53
Abstract: The present invention provides methods and reagents for detecting anti-phospholipid-cofactor protein-antibodies.
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公开(公告)号：DE69408842T2
公开(公告)日：1998-07-16
申请号：DE69408842
申请日：1994-05-04
Applicant: BIO RAD LABORATORIES
Inventor： BINDER STEVEN , KING DAVID
IPC: G01N30/02 , G01N30/06 , G01N30/08 , G01N30/14 , G01N30/34 , G01N30/46 , G01N30/74 , G01N30/86 , G01N30/88 , G01N33/94
Abstract: Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.
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Patent Agency Ranking3.发明专利
公开(公告)号：CA2603814C
公开(公告)日：2013-08-27
申请号：CA2603814
申请日：2006-04-18
Applicant: BIO RAD LABORATORIES
Inventor： WATKINS MICHAEL , PRESTIGIACOMO TONY , BINDER STEVEN , WOEI TAN
IPC: G01N33/564 , C07K14/775 , C07K17/00 , C12N9/74 , C12N11/00
Abstract: The present invention provides methods and reagents for detecting antibodies against phospholipid-cofactor proteins. Phospholipids include cardiolipin. Cofactor proteins include beta-2-glycoprotein-1 (i.e., apolipoprotein H) or a prothrombin protein. Detection is accomplished with flow cytometry (e.g., fluorescence-activated cell sorting, facs).
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4.发明专利
公开(公告)号：CA2603814A1
公开(公告)日：2006-10-26
申请号：CA2603814
申请日：2006-04-18
Applicant: BIO RAD LABORATORIES
Inventor： WATKINS MICHAEL , BINDER STEVEN , PRESTIGIACOMO TONY , WOEI TAN
IPC: G01N33/567 , G01N33/53
Abstract: The present invention provides methods and reagents for detecting antibodies against phospholipid-cofactor proteins. Phospholipids include cardiolipin. Cofactor proteins include beta-2-glycoprotein-1 (i.e., apolipoprotein H) or a prothrombin protein. Detection is accomplished with flow cytometry (e.g., fluorescence-activated cell sorting, facs).
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公开(公告)号：DE69408842D1
公开(公告)日：1998-04-09
申请号：DE69408842
申请日：1994-05-04
Applicant: BIO RAD LABORATORIES
Inventor： BINDER STEVEN , KING DAVID
IPC: G01N30/02 , G01N30/06 , G01N30/08 , G01N30/14 , G01N30/34 , G01N30/46 , G01N30/74 , G01N30/86 , G01N30/88 , G01N33/94
Abstract: Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.
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6.发明申请SOLID PHASE IMMOBILIZATION OF PHOSPHOLIPIDS AND COFACTOR PROTEINS VIA COVALENT ATTACHMENT 审中-公开通过共价连接实现磷脂和凝血酶蛋白的固相化
公开(公告)号：WO2006113720A3
公开(公告)日：2007-04-26
申请号：PCT/US2006014572
申请日：2006-04-18
Applicant: BIO RAD LABORATORIES , WATKINS MICHAEL , PRESTIGIACOMO TONY , BINDER STEVEN , WOEI TAN
Inventor： WATKINS MICHAEL , PRESTIGIACOMO TONY , BINDER STEVEN , WOEI TAN
IPC: G01N33/567 , G01N33/53
CPC classification number: G01N33/566 , G01N33/543 , G01N33/92 , G01N2405/04 , G01N2800/226 , G01N2800/24
Abstract: The present invention provides methods and reagents for detecting antibodies against phospholipid-cofactor proteins. Phospholipids include cardiolipin. Cofactor proteins include beta-2-glycoprotein-1 (i.e., apolipoprotein H) or a prothrombin protein. Detection is accomplished with flow cytometry (e.g., fluorescence-activated cell sorting, facs).
Abstract translation: 本发明提供用于检测针对磷脂辅助因子蛋白的抗体的方法和试剂。 磷脂包括心磷脂。 辅因子蛋白包括β-2-糖蛋白-1（即载脂蛋白H）或凝血酶原蛋白。 用流式细胞术（例如，荧光激活细胞分选，facs）完成检测。
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7.发明公开SOLID PHASE IMMOBILIZATION OF PHOSPHOLIPIDS AND COFACTOR PROTEINS VIA COVALENT ATTACHMENT 有权FESTPHASENIMMOBILISIERUNG VON PHOSPHOLIDIDEN UND COFAKTORPROTEINEN DURCH KOVALENTE BINDUNG
公开(公告)号：EP1872132A4
公开(公告)日：2008-12-31
申请号：EP06769840
申请日：2006-04-18
Applicant: BIO RAD LABORATORIES
Inventor： WATKINS MICHAEL , PRESTIGIACOMO TONY , BINDER STEVEN , WOEI TAN
IPC: G01N33/53 , G01N33/566 , G01N33/92
CPC classification number: G01N33/566 , G01N33/543 , G01N33/92 , G01N2405/04 , G01N2800/226 , G01N2800/24
Abstract: The present invention provides methods and reagents for detecting antibodies against phospholipid-cofactor proteins. Phospholipids include cardiolipin. Cofactor proteins include beta-2-glycoprotein-1 (i.e., apolipoprotein H) or a prothrombin protein. Detection is accomplished with flow cytometry (e.g., fluorescence-activated cell sorting, facs).
Abstract translation: 本发明提供了检测抗磷脂辅因子蛋白质抗体的方法和试剂。 磷脂包括心磷脂。 辅因子蛋白包括β-2-糖蛋白-1（即载脂蛋白H）或凝血酶原蛋白。 用流式细胞术（例如荧光激活细胞分选，facs）完成检测。
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