公开(公告)号：DE69408842D1

公开(公告)日：1998-04-09

申请号：DE69408842

申请日：1994-05-04

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN ,  KING DAVID

IPC: G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/14 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/86 ,  G01N30/88 ,  G01N33/94

Abstract: Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.

公开(公告)号：DE69408842T2

公开(公告)日：1998-07-16

申请号：DE69408842

申请日：1994-05-04

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN ,  KING DAVID

IPC: G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/14 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/86 ,  G01N30/88 ,  G01N33/94

Abstract: Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.

公开(公告)号：ES2821654T3

公开(公告)日：2021-04-27

申请号：ES17191779

申请日：2013-06-20

Applicant: BIO RAD LABORATORIES

Inventor： KING DAVID ,  LINK WILLIAM F ,  DEL ROSARIO RENATO ,  LEOS MICHAEL

IPC: G01N33/552 ,  G01N33/543 ,  G01N33/551

Abstract: Un kit para corregir las variaciones en el procesamiento de muestras y/o efectos de la matriz biológica cuando se realizan ensayos biológicos, comprendiendo dicho kit un factor de normalización que no se une a un analito de la muestra biológica a ensayar y que se acopla a un soporte sólido, en el que el factor de normalización es hFXIII, y una pluralidad de soportes sólidos que tienen miembros de unión inmovilizados sobre ellos que se unen a uno o más analitos en la muestra.

公开(公告)号：EP2864787A4

公开(公告)日：2016-02-17

申请号：EP13806909

申请日：2013-06-20

Applicant: BIO RAD LABORATORIES

Inventor： KING DAVID ,  LINK WILLIAM F ,  DEL ROSARIO RENATO ,  LEOS MICHAEL

IPC: G01N33/552 ,  G01N33/543 ,  G01N33/551

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

Abstract translation: 本公开提供可用于标准化测定中检测到的信号量的组合物和方法，例如免疫测定。 组合物和方法可用于提高免疫测定的准确性，例如检测受试者是否感染逆转录病毒如HIV的免疫测定。