公开(公告)号：WO2014039605A3

公开(公告)日：2015-07-30

申请号：PCT/US2013058137

申请日：2013-09-05

Applicant: BIO RAD LABORATORIES

Inventor： WALKER ROGER ,  BRENEMAN JOHN WESLEY III

IPC: A61K39/395

CPC classification number: C12Q1/6804 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/5308 ,  G01N33/564

Abstract: Provided herein are antibodies for determining the concentration of anti-dsDNA and anti-chromatin antibodies in biological samples. In some embodiments, the presently described antibodies are single chain antibodies (e.g., scFv) that specifically bind double-stranded DNA (dsDNA) and chromatin. In some embodiments, the presently described antibodies are chimeric, and specifically bind double-stranded DNA (dsDNA) and chromatin. Such antibodies are referred to as chimeric anti-dsDNA/chromatin antibodies. Ln some embodiments, at least part of the constant region of the chimeric antibody is derived from a human antibody, e.g., a part of the constant region specifically recognized by a secondary antibody, Protein A, Protein G, or Protein A/G. In some embodiments, the constant region is derived from a human antibody.

Abstract translation: 本文提供了用于测定生物样品中抗dsDNA和抗染色质抗体浓度的抗体。 在一些实施方案中，目前描述的抗体是特异性结合双链DNA（dsDNA）和染色质的单链抗体（例如，scFv）。 在一些实施方案中，目前描述的抗体是嵌合的，并且特异性结合双链DNA（dsDNA）和染色质。 这种抗体被称为嵌合抗dsDNA /染色质抗体。 在一些实施方案中，嵌合抗体的恒定区的至少一部分衍生自人抗体，例如由二抗，蛋白A，蛋白G或蛋白A / G特异性识别的一部分恒定区。 在一些实施方案中，恒定区源自人抗体。

公开(公告)号：EP2893041A4

公开(公告)日：2016-07-06

申请号：EP13834463

申请日：2013-09-05

Applicant: BIO RAD LABORATORIES

Inventor： WALKTER ROGER ,  BRENEMAN JOHN WESLEY III

IPC: A61K39/395 ,  C07K16/18

CPC classification number: C12Q1/6804 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/5308 ,  G01N33/564

Abstract: Provided herein are antibodies for determining the concentration of anti-dsDNA and anti-chromatin antibodies in biological samples.