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    CHIMERIC ANTI-DSDNA/CHROMATIN ANTIBODY
    2.
    发明申请
    CHIMERIC ANTI-DSDNA/CHROMATIN ANTIBODY 审中-公开
    CHIMERIC抗dsDNA /染色体抗体

    公开(公告)号：WO2014039605A3

    公开(公告)日：2015-07-30

    申请号：PCT/US2013058137

    申请日：2013-09-05

    Applicant: BIO RAD LABORATORIES

    Inventor： WALKER ROGER ,  BRENEMAN JOHN WESLEY III

    IPC: A61K39/395

    CPC classification number: C12Q1/6804 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/5308 ,  G01N33/564

    Abstract: Provided herein are antibodies for determining the concentration of anti-dsDNA and anti-chromatin antibodies in biological samples. In some embodiments, the presently described antibodies are single chain antibodies (e.g., scFv) that specifically bind double-stranded DNA (dsDNA) and chromatin. In some embodiments, the presently described antibodies are chimeric, and specifically bind double-stranded DNA (dsDNA) and chromatin. Such antibodies are referred to as chimeric anti-dsDNA/chromatin antibodies. Ln some embodiments, at least part of the constant region of the chimeric antibody is derived from a human antibody, e.g., a part of the constant region specifically recognized by a secondary antibody, Protein A, Protein G, or Protein A/G. In some embodiments, the constant region is derived from a human antibody.

    Abstract translation: 本文提供了用于测定生物样品中抗dsDNA和抗染色质抗体浓度的抗体。 在一些实施方案中，目前描述的抗体是特异性结合双链DNA（dsDNA）和染色质的单链抗体（例如，scFv）。 在一些实施方案中，目前描述的抗体是嵌合的，并且特异性结合双链DNA（dsDNA）和染色质。 这种抗体被称为嵌合抗dsDNA /染色质抗体。 在一些实施方案中，嵌合抗体的恒定区的至少一部分衍生自人抗体，例如由二抗，蛋白A，蛋白G或蛋白A / G特异性识别的一部分恒定区。 在一些实施方案中，恒定区源自人抗体。

    Calibration surface method for determination of analyte ratios
    5.
    发明专利
    Calibration surface method for determination of analyte ratios 未知

    公开(公告)号：AU2009282958A1

    公开(公告)日：2010-02-25

    申请号：AU2009282958

    申请日：2009-08-13

    Applicant: BIO RAD LABORATORIES

    Inventor： LIKUSKI ROBERT ,  WALKER ROGER ,  LU YABIN

    IPC: G01N33/53 ,  G01N33/533

    Abstract: The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio.

    CALIBRATION SURFACE METHOD FOR DETERMINATION OF ANALYTE RATIOS
    6.
    发明申请
    CALIBRATION SURFACE METHOD FOR DETERMINATION OF ANALYTE RATIOS 审中-公开
    用于确定分析比例的校准表面方法

    公开(公告)号：WO2010021914A2

    公开(公告)日：2010-02-25

    申请号：PCT/US2009053746

    申请日：2009-08-13

    Applicant: BIO RAD LABORATORIES ,  LIKUSKI ROBERT ,  WALKER ROGER ,  LU YABIN

    Inventor： LIKUSKI ROBERT ,  WALKER ROGER ,  LU YABIN

    IPC: G01N33/53 ,  G01N33/533

    CPC classification number: G01N33/723 ,  G01N33/721

    Abstract: The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio.

    Abstract translation: 分析物的比例直接由使用转化方法的分析物的反应确定。 通过使用选定的测量技术获得单个分析物响应，并且将这些单独的反应用作转化方法中的独立变量。 转化方法的因变量是所需的分析物比例。 然后使用所得的转化方法直接计算作为测量响应的函数的分析物的期望比例。 不需要中间转换，例如使用校正曲线将单个测量的分析物反应转化为浓度值，以获得所需的比例。

    RECOMBINANT DEAMIDATED GLIADIN ANTIGEN
    7.
    发明申请
    RECOMBINANT DEAMIDATED GLIADIN ANTIGEN 审中-公开
    重组体灭活的GLIADIN抗原

    公开(公告)号：WO2013085851A3

    公开(公告)日：2014-08-14

    申请号：PCT/US2012067639

    申请日：2012-12-03

    Applicant: BIO RAD LABORATORIES

    Inventor： WALKER ROGER ,  LU YABIN ,  DESAI URVEE ,  SHAN DAMING

    IPC: G01N33/53 ,  G01N33/543

    CPC classification number: G01N33/6893 ,  C07K14/415 ,  C07K2319/21 ,  C07K2319/23 ,  C12N9/1044 ,  C12Y203/02013 ,  G01N33/564 ,  G01N2800/06

    Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a hexamer of a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing the gliadin fusion protein on the solid support. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase.

    Abstract translation: 本发明提供了一种用于通过使来自受试者的体液样品与固定在固体支持物上的麦醇溶蛋白融合蛋白的六聚体形成的抗原来确定受试者是否患有乳糜泻的方法。 抗原的麦醇溶蛋白融合蛋白包括与诸如谷胱甘肽-S转移酶（GST）蛋白质的标签连接的重组脱酰胺麦醇溶蛋白。 通过将麦醇溶蛋白融合蛋白固定在固体支持物上来制备抗原。 抗原可以进一步包括与麦醇溶蛋白融合蛋白交联的组织转谷氨酰胺酶（tTG）。 当存在tTG时，将tTG和重组脱酰基麦醇溶蛋白在固定固相之前混合在一起。

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