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公开(公告)号：DE3618884C2
公开(公告)日：1995-04-06
申请号：DE3618884
申请日：1986-06-05
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G
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公开(公告)号：FR2664825A1
公开(公告)日：1992-01-24
申请号：FR9108597
申请日：1991-07-09
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G , PENALUNA WILLIAM A , JANET GEISSELSODER
Abstract: A plate assembly for performing multiple filtrations with the use of a vacuum offers advantages for small samples due to the construction of its component plates, which include an upper plate with apertures forming sample wells, a membrane sheet forming the floor of each well, a collection plate with individual wells underneath the membrane sheet, aligned with the upper plate apertures, and a drop guide plate between the membrane sheet and the collection plate to guide and force small quantities of liquid downward from the membrane into the collection wells. The arrangement permits extremely small quantities of species on the membrane to be drawn into the collection wells without dilution, and avoids cross contamination between collection wells.
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公开(公告)号：CA1284415C
公开(公告)日：1991-05-28
申请号：CA525266
申请日：1986-12-12
Applicant: BIO RAD LABORATORIES
Inventor： SLEETER DONALD D , FERNWOOD GEORGE G , BURD SAMUEL
IPC: C08F2/10 , G01N27/26 , G01N27/447 , B29C39/24 , G01N27/28
Abstract: APPARATUS AND METHOD FOR GEL CASTING A gel used for electrophoresis is cast in a gel enclosure in which the gel will ultimately be used during the electrophoresis, by a novel method and using novel apparatus which provide for quick assembly and avoidance of leaks. The method and apparatus involve a wettable, preferably porous, membrane such as filter paper, which is thoroughly wetted with gel forming solution, then placed over the bottom opening of the gel enclosure and held in place until the gel on the membrane sets. Sealing of any cracks, gaps or irregularities along the rim of the opening is thereby achieved by the capillary action of the gel forming solution. The enclosure itself is then filled with gel forming solution. Once the latter has set, the membrane is removed.
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4.发明专利
公开(公告)号：GB2176601B
公开(公告)日：1989-02-01
申请号：GB8611533
申请日：1986-05-12
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G
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5.发明专利
公开(公告)号：GB2176601A
公开(公告)日：1986-12-31
申请号：GB8611533
申请日：1986-05-12
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G
Abstract: A biochemical test plate assembly for use in multiple simultaneous contact tests arranged in a fixed array of discrete regions on a single microporous membrane sheet provides less distortion of the boundaries of these regions than do pre-existing assemblies. The assembly contains two apertured plates 11, 13; an apertured gasket sheet 17 and a microporous membrane 19, both placed between the apertured plates; and a third plate 15 for placement beneath the apertured plates, having a recess which serves as a reservoir for liquids passing through the membrane. The improvement resides in the enclosure of the lower apertured plate by the upper apertured plate and a recess in the base plate, thereby sealing the lower apertured plate and the microporous membrane off entirely from the atmosphere. This eliminates evaporation of moisture from the edges of the membrane, and any lateral diffusion of biochemical species which might occur as a result due to capillary attraction. The floor of the base plate may slope towards a vacuum port 46.
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Patent Agency Ranking
公开(公告)号：CA1210309A
公开(公告)日：1986-08-26
申请号：CA455733
申请日：1984-06-01
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G , BURD SAMUEL
Abstract: 12 DUAL PURPOSE BIOCHEMICAL TEST PLATE ASSEMBLY A biochemical test plate assembly is disclosed for use in both filter assays and static blotting applications. The assembly comprises an upper template with a plurality of discrete apertures, a continuous microporous film underlying the upper template, a gasket underlying the microporous film with apertures matching those of the upper template, a lower template underlying the gasket with a similar array of apertures matching those of both the upper template and the gasket, each aperture terminating at its upper end in a flat boss, and a base plate having a central recess to define an enclosed chamber when the base plate and lower template are in contact, the base plate being designed to form an air-tight seal between it and the power template.
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公开(公告)号：DE4123874C2
公开(公告)日：1996-09-19
申请号：DE4123874
申请日：1991-07-18
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G , PENALUNA WILLIAM A , GEISSELSODER JANET
Abstract: A plate assembly for performing multiple filtrations with the use of a vacuum offers advantages for small samples due to the construction of its component plates, which include an upper plate with apertures forming sample wells, a membrane sheet forming the floor of each well, a collection plate with individual wells underneath the membrane sheet, aligned with the upper plate apertures, and a drop guide plate between the membrane sheet and the collection plate to guide and force small quantities of liquid downward from the membrane into the collection wells. The arrangement permits extremely small quantities of species on the membrane to be drawn into the collection wells without dilution, and avoids cross contamination between collection wells.
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公开(公告)号：FR2664825B1
公开(公告)日：1994-08-19
申请号：FR9108597
申请日：1991-07-09
Applicant: BIO RAD LABORATORIES
Inventor： FERNWOOD GEORGE G , PENALUNA WILLIAM A , GEISSELSODER JANET
Abstract: A plate assembly for performing multiple filtrations with the use of a vacuum offers advantages for small samples due to the construction of its component plates, which include an upper plate with apertures forming sample wells, a membrane sheet forming the floor of each well, a collection plate with individual wells underneath the membrane sheet, aligned with the upper plate apertures, and a drop guide plate between the membrane sheet and the collection plate to guide and force small quantities of liquid downward from the membrane into the collection wells. The arrangement permits extremely small quantities of species on the membrane to be drawn into the collection wells without dilution, and avoids cross contamination between collection wells.
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9.发明专利
公开(公告)号：CA1296294C
公开(公告)日：1992-02-25
申请号：CA513166
申请日：1986-07-04
Applicant: BIO RAD LABORATORIES
Inventor： SLEETER DONALD D , VON ALVEN RAYMOND D , FERNWOOD GEORGE G
IPC: G01N33/50 , G01N27/26 , G01N27/447 , B01D57/02 , G01N27/453
Abstract: 16 ELECTROPHORESIS APPARATUS FOR NUCLEIC ACID SEQUENCING An integrated plate structure provides a novel component for use in an electrophoretic sequencing cell. The integrated plate structure consists of a glass plate and a plastic plate bonded together along a raised edge of the latter, the edge extending along the sides and bottom of the plastic plate. The plates thus form a permanent enclosure for an upper buffer solution, open at the top for filling. The glass plate further serves as one of the two glass plates forming the gel enclosure.
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公开(公告)号：DE3642551A1
公开(公告)日：1987-07-09
申请号：DE3642551
申请日：1986-12-12
Applicant: BIO RAD LABORATORIES
Inventor： SLEETER DONALD D , FERNWOOD GEORGE G , BURD SAMUEL
IPC: C08F2/10 , G01N27/26 , G01N27/447 , B01D13/04 , B01D13/00 , B01D57/02 , C08F20/56 , C08J5/18 , C08L33/26 , G01N27/28
Abstract: A gel used for electrophoresis is cast in a gel enclosure in which the gel will ultimately be used during the electrophoresis, by a novel method and using novel apparatus which provide for quick assembly and avoidance of leaks. The method and apparatus involve a wettable, preferably porous, membrane such as filter paper, which is thoroughly wetted with gel forming solution, then placed over the bottom opening of the gel enclosure and held in place until the gel on the membrane sets. Sealing of any cracks, gaps or irregularities along the rim of the opening is thereby achieved by the capillary action of the gel forming solution. The enclosure itself is then filled with gel forming solution. Once the latter has set, the membrane is removed.
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